Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone

Drug Metabolism and Disposition

Volumn 29, Issue 2, 2001, Pages 145-151

  Yumoto, Ryoko ^a   Murakami, Teruo ^a   Sanemasa, Maki ^a   Nasu, Reishi ^a   Nagai, Junya ^a   Takano, Mikihisa ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; DEXAMETHASONE; GLYCOPROTEIN P; MIDAZOLAM; RHODAMINE 123; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CLEARANCE; DRUG INHIBITION; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG POTENCY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BILIARY TRACT; BLOTTING, WESTERN; CYCLOSPORINE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DRUG INTERACTIONS; ERYTHROMYCIN; INTESTINAL ABSORPTION; INTESTINES; LIVER; MALE; MIDAZOLAM; OXIDOREDUCTASES, N-DEMETHYLATING; P-GLYCOPROTEIN; RATS; RATS, WISTAR; RHODAMINE 123; SUBSTRATE SPECIFICITY; VERAPAMIL;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0035152973     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Cytochrome P450 of small intestinal epithelial cells. Immunochemical characterization of the increase in cytochrome P450 caused by phenobarbital
2. Effect of cytochrome P450 inducers on cocaine-mediated hepatotoxicity
3. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
4. Theoretical and practical considerations for the measurement of P-glycoprotein function in acute myeloid leukemia
5. Identification of a sister gene to P-glycoprotein
6. Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR
7. Dexamethasone modulation of multidrug transporters in normal tissues
8. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities
9. Modulation of multidrug resistance gene expression in rat hepatocytes maintained under various culture conditions
10. Functional detection of MDRI/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry
11. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
12. Effects of rifampin on tacrolimus pharmacokinetics in healthy volunteers
13. Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists
14. Dose-dependent intestinal and hepatic first-pass metabolism of midazolam, a cytochrome P450 3A substrate with differently modulated enzyme activity in rats
15. In-vivo and in-vitro metabolic clearance of midazolam, a cytochrome P450 3A substrate, by the liver under normal and increased enzyme activity in rats
16. Role of P-glycoprotein in distribution of rhodamine 123 into aqueous humor in rabbits
17. Role of P-glycoprotein in ocular clearance of rhodamine 123 in rabbits
18. Effects of steroid hormones and cyclosporine A on taurine-transporter activity in the RAW264.7 cell line
19. Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cells
20. Renal excretion of rhodamine 123, a P-glycoprotein substrate, in rats with glycerol-induced acute renal failure
21. Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen
22. The induction of hepatic cytochrome P450 3A in rats: Effect of age
23. Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: Evidence of cytochrome P-450 A and F-glycoprotein induction
24. Role of intestinal F-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine
25. Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism
26. First-pass metabolism of midazolam by the human intestine
27. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein
28. Phosphatidylcholine translocase: A physiological role for the mdr2 gene
29. Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat liver
30. P-glycoprotein substrates and antagonists cluster into two distinct groups
31. +-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells
32. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
33. Modulation of MDR1 and CYP3A expression by dexamethasone: Evidence for an inverse regulation in adrenals
34. Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site
35. Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities
36. Metabolism and elimination of rhodamine 123 in the rat
37. Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells
38. Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier
39. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
40. Sister of P-glycoprotein expression in different tissues
41. Carrier-mediated intestinal transport of drugs
42. Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology
43. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
44. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
45. Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P450. Studies in rats and patients
46. Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man
47. Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation
48. Cytochrome P4503A (CYP3A) metabolism: Prediction of in vivo activity in humans
49. Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics
50. Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds
51. Posttranslational elevation of cytochrome P450 3A levels and activity by dimethyl sulfoxide
52. Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells
53. Induction of expression of MDR1 gene by retinoic acid and DMSO and effects on rhodamine- 123 efflux in HL-60 cell lines and resistant sublines