Drug disposition as determined by the interplay between drug-transporting and drug-metabolizing systems

Journal of Biochemical and Molecular Toxicology

Volumn 13, Issue 3-4, 1999, Pages 219-222

  Schuetz, Erin G ^a   Schinkel, Alfred H ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANION TRANSPORT PROTEIN; CARRIER PROTEIN; CYTOCHROME P450; GLYCOPROTEIN P;

ENZYME SPECIFICITY; HUMAN; INTESTINE; METABOLISM; PHARMACOKINETICS; PHYSIOLOGY; REVIEW; TRANSPORT AT THE CELLULAR LEVEL;

ANION TRANSPORT PROTEINS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; INTESTINES; P-GLYCOPROTEIN; PHARMACOKINETICS; SUBSTRATE SPECIFICITY;

EID: 0032601755     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1099-0461(1999)13:3/4<219::aid-jbt13>3.0.co;2-z     Document Type: Article

References (4)

1. Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 1993;62:385-427.
2. Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP, Berns AJM, Borst P. Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994;77:491-502.
3. Sparreboom A, van Asperen J, Mayer U, Schinkel AH, Smit JW, Meijer D, Borst P, Nooijen WJ, Beijnen JH, van Tellingen O. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sci USA 1997;94:2031-2035.
4. Schinkel AH. The physiological function of drug-transporting P-glycoproteins. Sem Cancer Biol 1997;8:161-170.