메뉴 건너뛰기




Volumn 24, Issue 4, 2004, Pages 239-250

Interleukin 21: A key player in lymphocyte maturation

Author keywords

Antitumor function; B cell differentiation; IL 21; Natural killer cell; Terminal differentiation

Indexed keywords

ANTINEOPLASTIC AGENT; CD4 ANTIGEN; CETUXIMAB; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 21; RITUXIMAB; TRASTUZUMAB;

EID: 11144237694     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevImmunol.v24.i4.20     Document Type: Review
Times cited : (33)

References (71)
  • 1
    • 0033118752 scopus 로고    scopus 로고
    • The role of cytokine receptor signaling in lymphocyte development
    • Baird AM, Gerstein RM, Berg LJ. The role of cytokine receptor signaling in lymphocyte development. Curr Opin Immunol 1999; 11:157-166.
    • (1999) Curr Opin Immunol , vol.11 , pp. 157-166
    • Baird, A.M.1    Gerstein, R.M.2    Berg, L.J.3
  • 2
    • 0037119351 scopus 로고    scopus 로고
    • Cytokine and cytokine receptor pleiotropy and redundancy
    • Ozaki K, Leonard WJ. Cytokine and cytokine receptor pleiotropy and redundancy. J Biol Chem 2002; 277:29355-29358.
    • (2002) J Biol Chem , vol.277 , pp. 29355-29358
    • Ozaki, K.1    Leonard, W.J.2
  • 3
    • 0031755547 scopus 로고    scopus 로고
    • Natural killer and T cells of innate and adaptive immunity: Lymphoid compartments with different requirements for common gamma chain-dependent cytokines
    • Di Santo JP, Colucci F, Guy-Grand D. Natural killer and T cells of innate and adaptive immunity: lymphoid compartments with different requirements for common gamma chain-dependent cytokines. Immunol Rev 1998; 165:29-38.
    • (1998) Immunol Rev , vol.165 , pp. 29-38
    • Di Santo, J.P.1    Colucci, F.2    Guy-Grand, D.3
  • 4
    • 0035752146 scopus 로고    scopus 로고
    • Cytokines and immunodeficiency diseases
    • Leonard WJ. Cytokines and immunodeficiency diseases. Nat Rev Immunol 2001; 1:200-208.
    • (2001) Nat Rev Immunol , vol.1 , pp. 200-208
    • Leonard, W.J.1
  • 7
    • 0028957771 scopus 로고
    • The conserved box 1 motif of cytokine receptors is required for association with JAK kinases
    • Tanner JW, Chen W, Young RL, Longmore GD, Shaw AS. The conserved box 1 motif of cytokine receptors is required for association with JAK kinases. J Biol Chem 1995; 270:6523-6530.
    • (1995) J Biol Chem , vol.270 , pp. 6523-6530
    • Tanner, J.W.1    Chen, W.2    Young, R.L.3    Longmore, G.D.4    Shaw, A.S.5
  • 8
    • 0037047025 scopus 로고    scopus 로고
    • The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3
    • Habib T, Senadheera S, Weinberg K, Kaushansky K. The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. Biochemistry 2002; 41:8725-8731.
    • (2002) Biochemistry , vol.41 , pp. 8725-8731
    • Habib, T.1    Senadheera, S.2    Weinberg, K.3    Kaushansky, K.4
  • 9
    • 0035400054 scopus 로고    scopus 로고
    • Cutting edge: The common gamma-chain is an indispensable subunit of the IL-21 receptor complex
    • Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, Sugamura K. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol 2001; 167:1-5.
    • (2001) J Immunol , vol.167 , pp. 1-5
    • Asao, H.1    Okuyama, C.2    Kumaki, S.3    Ishii, N.4    Tsuchiya, S.5    Foster, D.6    Sugamura, K.7
  • 10
    • 0036852893 scopus 로고    scopus 로고
    • Interleukin-21 and the IL-21 receptor: Novel effectors of NK and T cell responses
    • Parrish-Novak J, Foster DC, Holly RD, Clegg CH. Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol 2002; 72:856-863.
    • (2002) J Leukoc Biol , vol.72 , pp. 856-863
    • Parrish-Novak, J.1    Foster, D.C.2    Holly, R.D.3    Clegg, C.H.4
  • 11
    • 0344394529 scopus 로고    scopus 로고
    • IL-21 and IL-21 receptor: A new cytokine pathway modulates innate and adaptive immunity
    • Collins M, Whitters MJ, Young DA. IL-21 and IL-21 receptor: a new cytokine pathway modulates innate and adaptive immunity. Immunol Res 2003; 28:131-140.
    • (2003) Immunol Res , vol.28 , pp. 131-140
    • Collins, M.1    Whitters, M.J.2    Young, D.A.3
  • 12
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
    • Jin H, Carrio R, Yu A, Malek TR. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol 2004; 173:657-665.
    • (2004) J Immunol , vol.173 , pp. 657-665
    • Jin, H.1    Carrio, R.2    Yu, A.3    Malek, T.R.4
  • 13
    • 0345257344 scopus 로고    scopus 로고
    • Interleukin-21 inhibits dendritic cell activation and maturation
    • Brandt K, Bulfone-Paus S, Foster DC, Ruckert R. Interleukin-21 inhibits dendritic cell activation and maturation. Blood 2003; 102:4090-4098.
    • (2003) Blood , vol.102 , pp. 4090-4098
    • Brandt, K.1    Bulfone-Paus, S.2    Foster, D.C.3    Ruckert, R.4
  • 14
    • 0346993779 scopus 로고    scopus 로고
    • Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo
    • Brandt K, Bulfone-Paus S, Jenckel A, Foster DC, Paus R, Ruckert R. Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo. J Invest Dermatol 2003; 121:1379-1382.
    • (2003) J Invest Dermatol , vol.121 , pp. 1379-1382
    • Brandt, K.1    Bulfone-Paus, S.2    Jenckel, A.3    Foster, D.C.4    Paus, R.5    Ruckert, R.6
  • 15
    • 0034812119 scopus 로고    scopus 로고
    • Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models
    • Todd JA, Wicker LS. Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models. Immunity 2001; 15:387-395.
    • (2001) Immunity , vol.15 , pp. 387-395
    • Todd, J.A.1    Wicker, L.S.2
  • 16
    • 1942453326 scopus 로고    scopus 로고
    • Homeostatic expansion of T cells during immune insufficiency generates autoimmunity
    • King C, Ilic A, Koelsch K, Sarvetnick N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 2004; 117:265-277.
    • (2004) Cell , vol.117 , pp. 265-277
    • King, C.1    Ilic, A.2    Koelsch, K.3    Sarvetnick, N.4
  • 17
    • 3442901047 scopus 로고    scopus 로고
    • IFN-{alpha} regulates IL-21 and IL-21R expression in human NK and T cells
    • Strengell M, Julkunen I, Matikainen S. IFN-{alpha} regulates IL-21 and IL-21R expression in human NK and T cells. J Leukoc Biol 2004; 76:416-422.
    • (2004) J Leukoc Biol , vol.76 , pp. 416-422
    • Strengell, M.1    Julkunen, I.2    Matikainen, S.3
  • 18
    • 0037037544 scopus 로고    scopus 로고
    • Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells
    • Wurster AL, Rodgers VL, Satoskar AR, Whitters MJ, Young DA, Collins M, Grusby MJ. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med 2002; 196:969-977.
    • (2002) J Exp Med , vol.196 , pp. 969-977
    • Wurster, A.L.1    Rodgers, V.L.2    Satoskar, A.R.3    Whitters, M.J.4    Young, D.A.5    Collins, M.6    Grusby, M.J.7
  • 19
    • 2542565699 scopus 로고    scopus 로고
    • Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses
    • Sivakumar PV, Foster DC, Clegg CH. Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. Immunology 2004; 112:177-182.
    • (2004) Immunology , vol.112 , pp. 177-182
    • Sivakumar, P.V.1    Foster, D.C.2    Clegg, C.H.3
  • 20
    • 0036784616 scopus 로고    scopus 로고
    • IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
    • Strengell M, Sareneva T, Foster D, Julkunen I, Matikainen S. IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J Immunol 2002; 169:3600-3605.
    • (2002) J Immunol , vol.169 , pp. 3600-3605
    • Strengell, M.1    Sareneva, T.2    Foster, D.3    Julkunen, I.4    Matikainen, S.5
  • 22
    • 0028929565 scopus 로고
    • Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a non-redundant cytokine
    • von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a non-redundant cytokine. J Exp Med 1995; 181:1519-1526.
    • (1995) J Exp Med , vol.181 , pp. 1519-1526
    • Von Freeden-Jeffry, U.1    Vieira, P.2    Lucian, L.A.3    McNeil, T.4    Burdach, S.E.5    Murray, R.6
  • 24
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce JP, Boone DL, Chai S, Swain RE, Dassopoulos T, Trettin S, Ma A. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 1998; 9:669-676.
    • (1998) Immunity , vol.9 , pp. 669-676
    • Lodolce, J.P.1    Boone, D.L.2    Chai, S.3    Swain, R.E.4    Dassopoulos, T.5    Trettin, S.6    Ma, A.7
  • 28
    • 0029946063 scopus 로고    scopus 로고
    • IL-15: A pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels
    • Tagaya Y, Bamford RN, DeFilippis AP, Waldmann TA. IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity 1996; 4:329-336.
    • (1996) Immunity , vol.4 , pp. 329-336
    • Tagaya, Y.1    Bamford, R.N.2    DeFilippis, A.P.3    Waldmann, T.A.4
  • 29
    • 0348047537 scopus 로고    scopus 로고
    • The main function of IL-2 is to promote the development of T regulatory cells
    • Malek TR. The main function of IL-2 is to promote the development of T regulatory cells. J Leukoc Biol 2003; 74:961-965.
    • (2003) J Leukoc Biol , vol.74 , pp. 961-965
    • Malek, T.R.1
  • 30
    • 0026328818 scopus 로고
    • Generation and analysis of interleukin-4 deficient mice
    • Kuhn R, Rajewsky K, Muller W. Generation and analysis of interleukin-4 deficient mice. Science 1991; 254:707-710.
    • (1991) Science , vol.254 , pp. 707-710
    • Kuhn, R.1    Rajewsky, K.2    Muller, W.3
  • 31
    • 0346995205 scopus 로고    scopus 로고
    • IL-21: A novel IL-2-family lymphokine that modulates B, T, and natural killer cell responses
    • Habib T, Nelson A, Kaushansky K. IL-21: a novel IL-2-family lymphokine that modulates B, T, and natural killer cell responses. J Allergy Clin Immunol 2003; 112:1033-1045.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 1033-1045
    • Habib, T.1    Nelson, A.2    Kaushansky, K.3
  • 33
    • 2542595794 scopus 로고    scopus 로고
    • IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: Comparative evaluation of IL-2, IL-15, and IL-21
    • Moroz A, Eppolito C, Li Q, Tao J, Clegg CH, Shrikant PA. IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21. J Immunol 2004; 173:900-909.
    • (2004) J Immunol , vol.173 , pp. 900-909
    • Moroz, A.1    Eppolito, C.2    Li, Q.3    Tao, J.4    Clegg, C.H.5    Shrikant, P.A.6
  • 36
    • 0027948090 scopus 로고
    • Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes
    • Wicker LS, Todd JA, Prins JB, Podolin PL, Renjilian RJ, Peterson LB. Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes. J Exp Med 1994; 180:1705-1713.
    • (1994) J Exp Med , vol.180 , pp. 1705-1713
    • Wicker, L.S.1    Todd, J.A.2    Prins, J.B.3    Podolin, P.L.4    Renjilian, R.J.5    Peterson, L.B.6
  • 39
    • 0037114638 scopus 로고    scopus 로고
    • Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells
    • Suto A, Nakajima H, Hirose K, Suzuki K, Kagami S, Seto Y, Hoshimoto A, Saito Y, Foster DC, Iwamoto I. Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells. Blood 2002; 100:4565-4573.
    • (2002) Blood , vol.100 , pp. 4565-4573
    • Suto, A.1    Nakajima, H.2    Hirose, K.3    Suzuki, K.4    Kagami, S.5    Seto, Y.6    Hoshimoto, A.7    Saito, Y.8    Foster, D.C.9    Iwamoto, I.10
  • 42
    • 4043108358 scopus 로고    scopus 로고
    • Divide and conquer: The importance of cell division in regulating B-cell responses
    • Tangye SG, Hodgkin PD. Divide and conquer: the importance of cell division in regulating B-cell responses. Immunology 2004; 112:509-520.
    • (2004) Immunology , vol.112 , pp. 509-520
    • Tangye, S.G.1    Hodgkin, P.D.2
  • 43
    • 0030037519 scopus 로고    scopus 로고
    • B cell differentiation and isotype switching is related to division cycle number
    • Hodgkin PD, Lee JH, Lyons AB. B cell differentiation and isotype switching is related to division cycle number. J Exp Med 1996; 184:277-281.
    • (1996) J Exp Med , vol.184 , pp. 277-281
    • Hodgkin, P.D.1    Lee, J.H.2    Lyons, A.B.3
  • 47
    • 0348013081 scopus 로고    scopus 로고
    • IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors
    • Sivori S, Cantoni C, Parolini S, Marcenaro E, Conte R, Moretta L, Moretta A. IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors. Eur J Immunol 2003; 33:3439-3447.
    • (2003) Eur J Immunol , vol.33 , pp. 3439-3447
    • Sivori, S.1    Cantoni, C.2    Parolini, S.3    Marcenaro, E.4    Conte, R.5    Moretta, L.6    Moretta, A.7
  • 48
    • 0842278642 scopus 로고    scopus 로고
    • IL-21 induces the functional maturation of murine NK cells
    • Brady J, Hayakawa Y, Smyth MJ, Nutt SL. IL-21 induces the functional maturation of murine NK cells. J Immunol 2004; 172:2048-2058.
    • (2004) J Immunol , vol.172 , pp. 2048-2058
    • Brady, J.1    Hayakawa, Y.2    Smyth, M.J.3    Nutt, S.L.4
  • 49
    • 0041349288 scopus 로고    scopus 로고
    • Cytokine requirements for the growth and development of mouse NK cells in vitro
    • Toomey JA, Gays F, Foster D, Brooks CG. Cytokine requirements for the growth and development of mouse NK cells in vitro. J Leukoc Biol 2003; 74:233-242.
    • (2003) J Leukoc Biol , vol.74 , pp. 233-242
    • Toomey, J.A.1    Gays, F.2    Foster, D.3    Brooks, C.G.4
  • 50
    • 0035949237 scopus 로고    scopus 로고
    • Cytokine expression by murine DX5+ cells in response to IL-12, IL-18, or the combination of IL-12 and IL-18
    • Chakir H, Lemay AM, Webb JR. Cytokine expression by murine DX5+ cells in response to IL-12, IL-18, or the combination of IL-12 and IL-18. Cell Immunol 2001; 212:71-81.
    • (2001) Cell Immunol , vol.212 , pp. 71-81
    • Chakir, H.1    Lemay, A.M.2    Webb, J.R.3
  • 51
    • 0034663813 scopus 로고    scopus 로고
    • Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18
    • Lauwerys BR, Garot N, Renauld JC, Houssiau FA. Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18. J Immunol 2000; 165:1847-1853.
    • (2000) J Immunol , vol.165 , pp. 1847-1853
    • Lauwerys, B.R.1    Garot, N.2    Renauld, J.C.3    Houssiau, F.A.4
  • 52
    • 0032700570 scopus 로고    scopus 로고
    • Synergistic proliferation and activation of natural killer cells by interleukin 12 and interleukin 18
    • Lauwerys BR, Renauld JC, Houssiau FA. Synergistic proliferation and activation of natural killer cells by interleukin 12 and interleukin 18. Cytokine 1999; 11: 822-830.
    • (1999) Cytokine , vol.11 , pp. 822-830
    • Lauwerys, B.R.1    Renauld, J.C.2    Houssiau, F.A.3
  • 53
    • 0033561762 scopus 로고    scopus 로고
    • Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: Implications for the innate immune response
    • Fehniger TA, Shah MH, Turner MJ, VanDeusen JB, Whitman SP, Cooper MA, Suzuki K, Wechser M, Goodsaid F, Caligiuri MA. Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. J Immunol 1999; 162:4511-4520.
    • (1999) J Immunol , vol.162 , pp. 4511-4520
    • Fehniger, T.A.1    Shah, M.H.2    Turner, M.J.3    Vandeusen, J.B.4    Whitman, S.P.5    Cooper, M.A.6    Suzuki, K.7    Wechser, M.8    Goodsaid, F.9    Caligiuri, M.A.10
  • 55
    • 0025819340 scopus 로고
    • Induction of interferon gamma production by natural killer cell stimulatory factor: Characterization of the responder cells and synergy with other inducers
    • Chan SH, Perussia B, Gupta JW, Kobayashi M, Pospisil M, Young HA, Wolf SF, Young D, Clark SC, Trinchieri G. Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med 1991; 173:869-879.
    • (1991) J Exp Med , vol.173 , pp. 869-879
    • Chan, S.H.1    Perussia, B.2    Gupta, J.W.3    Kobayashi, M.4    Pospisil, M.5    Young, H.A.6    Wolf, S.F.7    Young, D.8    Clark, S.C.9    Trinchieri, G.10
  • 57
    • 0037087340 scopus 로고    scopus 로고
    • Cutting edge: Inhibitory functions of the killer cell lectin-like receptor G1 molecule during the activation of mouse NK cells
    • Robbins SH, Nguyen KB, Takahashi N, Mikayama T, Biron CA, Brossay L. Cutting edge: inhibitory functions of the killer cell lectin-like receptor G1 molecule during the activation of mouse NK cells. J Immunol 2002; 168:2585-2589.
    • (2002) J Immunol , vol.168 , pp. 2585-2589
    • Robbins, S.H.1    Nguyen, K.B.2    Takahashi, N.3    Mikayama, T.4    Biron, C.A.5    Brossay, L.6
  • 59
    • 0032538916 scopus 로고    scopus 로고
    • Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b)
    • Vance RE, Kraft JR, Altman JD, Jensen PE, Raulet DH. Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J Exp Med 1998; 188:1841-1848.
    • (1998) J Exp Med , vol.188 , pp. 1841-1848
    • Vance, R.E.1    Kraft, J.R.2    Altman, J.D.3    Jensen, P.E.4    Raulet, D.H.5
  • 61
    • 0032805251 scopus 로고    scopus 로고
    • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
    • Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999; 6:1258-1266.
    • (1999) Gene Ther , vol.6 , pp. 1258-1266
    • Liu, F.1    Song, Y.2    Liu, D.3
  • 62
    • 0036369564 scopus 로고    scopus 로고
    • Hydrodynamics-based transfection: Simple and efficient method for introducing and expressing transgenes in animals by intravenous injection of DNA
    • Song YK, Liu F, Zhang G, Liu D. Hydrodynamics-based transfection: simple and efficient method for introducing and expressing transgenes in animals by intravenous injection of DNA. Methods Enzymol 2002; 346:92-105.
    • (2002) Methods Enzymol , vol.346 , pp. 92-105
    • Song, Y.K.1    Liu, F.2    Zhang, G.3    Liu, D.4
  • 63
    • 0037347311 scopus 로고    scopus 로고
    • Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts
    • Ugai S, Shimozato O, Kawamura K, Wang YQ, Yamaguchi T, Saisho H, Sakiyama S, Tagawa M. Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts. Cancer Gene Ther 2003; 10:187-192.
    • (2003) Cancer Gene Ther , vol.10 , pp. 187-192
    • Ugai, S.1    Shimozato, O.2    Kawamura, K.3    Wang, Y.Q.4    Yamaguchi, T.5    Saisho, H.6    Sakiyama, S.7    Tagawa, M.8
  • 64
    • 1442277104 scopus 로고    scopus 로고
    • Expression of interleukin-21 and -23 in human esophageal tumors produced antitumor effects in nude mice
    • Shan B, Yu L, Shimozato O, Li Q, Tagawa M. Expression of interleukin-21 and -23 in human esophageal tumors produced antitumor effects in nude mice. Anticancer Res 2004; 24:79-82.
    • (2004) Anticancer Res , vol.24 , pp. 79-82
    • Shan, B.1    Yu, L.2    Shimozato, O.3    Li, Q.4    Tagawa, M.5
  • 65
    • 12444328351 scopus 로고    scopus 로고
    • Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects
    • Ugai S, Shimozato O, Yu L, Wang YQ, Kawamura K, Yamamoto H, Yamaguchi T, Saisho H, Sakiyama S, Tagawa M. Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects. Cancer Gene Ther 2003; 10:771-778.
    • (2003) Cancer Gene Ther , vol.10 , pp. 771-778
    • Ugai, S.1    Shimozato, O.2    Yu, L.3    Wang, Y.Q.4    Kawamura, K.5    Yamamoto, H.6    Yamaguchi, T.7    Saisho, H.8    Sakiyama, S.9    Tagawa, M.10
  • 67
    • 0038784488 scopus 로고    scopus 로고
    • IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma
    • Ma HL, Whitters MJ, Konz RF, Senices M, Young DA, Grusby MJ, Collins M, Dunussi-Joannopoulos K. IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma. J Immunol 2003; 171:608-615.
    • (2003) J Immunol , vol.171 , pp. 608-615
    • Ma, H.L.1    Whitters, M.J.2    Konz, R.F.3    Senices, M.4    Young, D.A.5    Grusby, M.J.6    Collins, M.7    Dunussi-Joannopoulos, K.8
  • 68
    • 10744230081 scopus 로고    scopus 로고
    • Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma
    • Kishida T, Asada H, Itokawa Y, Cui FD, Shin-Ya M, Gojo S, Yasutomi K, Ueda Y, Yamagishi H, Imanishi J, Mazda O. Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma. Mol Ther 2003; 8:552-558.
    • (2003) Mol Ther , vol.8 , pp. 552-558
    • Kishida, T.1    Asada, H.2    Itokawa, Y.3    Cui, F.D.4    Shin-Ya, M.5    Gojo, S.6    Yasutomi, K.7    Ueda, Y.8    Yamagishi, H.9    Imanishi, J.10    Mazda, O.11
  • 69
    • 0034074164 scopus 로고    scopus 로고
    • Interleukin-2 in the treatment of renal cancer
    • Margolin KA. Interleukin-2 in the treatment of renal cancer. Semin Oncol 2000; 27:194-203.
    • (2000) Semin Oncol , vol.27 , pp. 194-203
    • Margolin, K.A.1
  • 71
    • 3042743884 scopus 로고    scopus 로고
    • Rituximab-dependent cytotoxicity by natural killer cells: Influence of FCGR3A polymorphism on the concentration-effect relationship
    • Dall'Ozzo S, Tartas S, Paintaud G, Cartron G, Colombat P, Bardos P, Watier H, Thibault G. Rituximab-dependent cytotoxicity by natural killer cells: influence of FCGR3A polymorphism on the concentration-effect relationship. Cancer Res 2004; 64:4664-4669.
    • (2004) Cancer Res , vol.64 , pp. 4664-4669
    • Dall'Ozzo, S.1    Tartas, S.2    Paintaud, G.3    Cartron, G.4    Colombat, P.5    Bardos, P.6    Watier, H.7    Thibault, G.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.