메뉴 건너뛰기




Volumn 161, Issue 1, 1998, Pages 128-137

In vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

EID: 0031831379     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (30)

References (49)
  • 1
    • 0016345568 scopus 로고
    • Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system
    • Zinkernagel, R. M., and P. C. Doherty. 1974. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248:701.
    • (1974) Nature , vol.248 , pp. 701
    • Zinkernagel, R.M.1    Doherty, P.C.2
  • 2
    • 0021968677 scopus 로고
    • Binding of immunogenic peptides to Ia histocompatibility molecules
    • Babbitt, B. P., P. M. Allen, G. Matsueda, E. Haber, and E. R. Unanue. 1985. Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 317:359.
    • (1985) Nature , vol.317 , pp. 359
    • Babbitt, B.P.1    Allen, P.M.2    Matsueda, G.3    Haber, E.4    Unanue, E.R.5
  • 3
    • 0029966057 scopus 로고    scopus 로고
    • Essential flexibility in the T-cell recognition of antigen
    • Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T-cell recognition of antigen. Nature 222:495.
    • (1996) Nature , vol.222 , pp. 495
    • Kersh, G.J.1    Allen, P.M.2
  • 4
    • 0026434554 scopus 로고
    • Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
    • Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
    • (1991) Science , vol.252 , pp. 1308
    • Evavold, B.D.1    Allen, P.M.2
  • 6
    • 0028979705 scopus 로고
    • Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous ligands
    • Evavold, B. D., J. Sloan-Lancaster, K. J. Wilson, J. B. Rothbard, and P. M. Allen. 1995. Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity 2:655.
    • (1995) Immunity , vol.2 , pp. 655
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Wilson, K.J.3    Rothbard, J.B.4    Allen, P.M.5
  • 7
    • 0027333348 scopus 로고
    • Tickling the TCR: Selective T cell functions stimulated by altered peptide ligands
    • Evavold, B. D., J. Sloan-Lancaster, and P. M. Allen. 1993. Tickling the TCR: selective T cell functions stimulated by altered peptide ligands. Immunol. Today 14:602.
    • (1993) Immunol. Today , vol.14 , pp. 602
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Allen, P.M.3
  • 8
    • 0027967385 scopus 로고
    • Partial T cell signaling: Altered phospho-ξ and lack of Zap 70 recruitment in APL-induced T cell anergy
    • Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signaling: altered phospho-ξ and lack of Zap 70 recruitment in APL-induced T cell anergy. Cell 79:913.
    • (1994) Cell , vol.79 , pp. 913
    • Sloan-Lancaster, J.1    Shaw, A.S.2    Rothbard, J.B.3    Allen, P.M.4
  • 9
    • 0028902752 scopus 로고
    • ξ Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
    • Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. E. Samelson, and R. N. Germain. 1995. ξ Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515.
    • (1995) Science , vol.267 , pp. 515
    • Madrenas, J.1    Wange, R.L.2    Wang, J.L.3    Isakov, N.4    Samelson, L.E.5    Germain, R.N.6
  • 11
    • 0028801774 scopus 로고
    • The T-cell receptor as a diverse signal transduction machine
    • Germain, R. N., E. H. Levine, and J. Madrenas. 1995. The T-cell receptor as a diverse signal transduction machine. Immunologist 3:113.
    • (1995) Immunologist , vol.3 , pp. 113
    • Germain, R.N.1    Levine, E.H.2    Madrenas, J.3
  • 14
    • 0028294682 scopus 로고
    • Positive and negative thymocyte selection induced by different concentrations of a single peptide
    • Sebzda, E., V. A. Wallace, J. Mayer, R. S. M. Yeung, T. W. Mak, and P. S. Ohashi. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263:1615.
    • (1994) Science , vol.263 , pp. 1615
    • Sebzda, E.1    Wallace, V.A.2    Mayer, J.3    Yeung, R.S.M.4    Mak, T.W.5    Ohashi, P.S.6
  • 15
    • 0028208488 scopus 로고
    • Peptides in positive and negative selection: A delicate balance
    • Allen, P. M. 1994. Peptides in positive and negative selection: a delicate balance. Cell 76:593.
    • (1994) Cell , vol.76 , pp. 593
    • Allen, P.M.1
  • 16
    • 0028017808 scopus 로고
    • A differential-avidity model for T-cell selection
    • Ashton-Rickardt, P. G., and S. Tonegawa. 1994. A differential-avidity model for T-cell selection. Immunol. Today 15:362.
    • (1994) Immunol. Today , vol.15 , pp. 362
    • Ashton-Rickardt, P.G.1    Tonegawa, S.2
  • 17
    • 0028988331 scopus 로고
    • T cell receptor antagonists and partial agonists
    • Jameson, S. C., and M. J. Bevan. 1995. T cell receptor antagonists and partial agonists. Immunity 2:1.
    • (1995) Immunity , vol.2 , pp. 1
    • Jameson, S.C.1    Bevan, M.J.2
  • 19
    • 0028872616 scopus 로고
    • Development and selection of T cells: Facts and puzzles
    • Kisielow, P., and H. von Boehmer. 1995. Development and selection of T cells: facts and puzzles. Adv. Immunol. 58:87.
    • (1995) Adv. Immunol. , vol.58 , pp. 87
    • Kisielow, P.1    Von Boehmer, H.2
  • 20
    • 0030806085 scopus 로고    scopus 로고
    • In thymic selection, peptide diversity gives and takes away
    • Bevan, M. J. 1997. In thymic selection, peptide diversity gives and takes away. Immunity 7:175.
    • (1997) Immunity , vol.7 , pp. 175
    • Bevan, M.J.1
  • 21
    • 0028281677 scopus 로고
    • A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes
    • Spain, L. M., J. L. Jorgensen, M. M. Davis, and L. J. Berg. 1994. A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes. J. Immunol. 152:1709.
    • (1994) J. Immunol. , vol.152 , pp. 1709
    • Spain, L.M.1    Jorgensen, J.L.2    Davis, M.M.3    Berg, L.J.4
  • 23
    • 0028911484 scopus 로고
    • Modulation of T cell development by an endogenous altered peptide ligand
    • Hsu, B. L., B. D. Evavold, and P. M. Allen. 1995. Modulation of T cell development by an endogenous altered peptide ligand. J. Exp. Med. 181:805.
    • (1995) J. Exp. Med. , vol.181 , pp. 805
    • Hsu, B.L.1    Evavold, B.D.2    Allen, P.M.3
  • 24
    • 0029862940 scopus 로고    scopus 로고
    • Endogenous altered peptide ligands can affect peripheral T cell responses
    • Vidal, K., B. L. Hsu, C. B. Williams, and P. M. Allen. 1996. Endogenous altered peptide ligands can affect peripheral T cell responses. J. Exp. Med. 183:1311.
    • (1996) J. Exp. Med. , vol.183 , pp. 1311
    • Vidal, K.1    Hsu, B.L.2    Williams, C.B.3    Allen, P.M.4
  • 25
    • 0029961893 scopus 로고    scopus 로고
    • Structural basis for T cell recognition of altered peptide ligands: A single T cell receptor can productively recognize a large continuum of related ligands
    • Kersh, G. J., and P. M. Allen. 1996. Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. J. Exp. Med. 184:1259.
    • (1996) J. Exp. Med. , vol.184 , pp. 1259
    • Kersh, G.J.1    Allen, P.M.2
  • 26
    • 0029782111 scopus 로고    scopus 로고
    • Structures of an MHC class II molecule with covalently bound single peptides
    • Fremont, D. H., W. A. Hendrickson, P. Marrack, and J. Kappler. 1996. Structures of an MHC class II molecule with covalently bound single peptides. Science 272:1001.
    • (1996) Science , vol.272 , pp. 1001
    • Fremont, D.H.1    Hendrickson, W.A.2    Marrack, P.3    Kappler, J.4
  • 27
    • 0026586413 scopus 로고
    • Complete dissection of the Hb(64-76) determinant using Th1, Th2 clones, and T cell hybridomas
    • Evavold, B. D., S. G. Williams, B. L. Hsu, S. Buus, and P. M. Allen. 1992. Complete dissection of the Hb(64-76) determinant using Th1, Th2 clones, and T cell hybridomas. J. Immunol. 148:347.
    • (1992) J. Immunol. , vol.148 , pp. 347
    • Evavold, B.D.1    Williams, S.G.2    Hsu, B.L.3    Buus, S.4    Allen, P.M.5
  • 28
    • 0027717869 scopus 로고
    • A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice
    • Kouskoff, V., H.-J. Periling, M. Lemeur, C. Benoist, and D. Mathis. 1993. A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice. J. Immunol. Methods 166:287.
    • (1993) J. Immunol. Methods , vol.166 , pp. 287
    • Kouskoff, V.1    Periling, H.-J.2    Lemeur, M.3    Benoist, C.4    Mathis, D.5
  • 29
    • 0030058657 scopus 로고    scopus 로고
    • The repertoire of T cells shaped by a single MHC/peptide ligand
    • Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84:521.
    • (1996) Cell , vol.84 , pp. 521
    • Ignatowicz, L.1    Kappler, J.2    Marrack, P.3
  • 31
    • 0021360513 scopus 로고
    • Differential requirement for antigen processing by macrophages for lysozyme-specific T cell hybridomas
    • Allen, P. M., and E. R. Unanue. 1984. Differential requirement for antigen processing by macrophages for lysozyme-specific T cell hybridomas. J. Immunol. 132:1077.
    • (1984) J. Immunol. , vol.132 , pp. 1077
    • Allen, P.M.1    Unanue, E.R.2
  • 32
    • 0020170133 scopus 로고
    • The fine specificity of antigen and Ia determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c
    • Hedrick, S. M., L. A. Matis, T. T. Hecht, L. E. Samelson, D. L. Longo, E. Heber-Katz, and R. H. Schwanz. 1982. The fine specificity of antigen and Ia determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c. Cell 30:141.
    • (1982) Cell , vol.30 , pp. 141
    • Hedrick, S.M.1    Matis, L.A.2    Hecht, T.T.3    Samelson, L.E.4    Longo, D.L.5    Heber-Katz, E.6    Schwanz, R.H.7
  • 33
    • 0024293245 scopus 로고
    • Crystallization and preliminary X-ray diffraction studies of two new antigen-antibody (Lysozyme-Fab) complexes
    • Fischmann, T., H. Souchon, M. -M. Riottot, D. Tello, and R. J. Poljak. 1988. Crystallization and preliminary X-ray diffraction studies of two new antigen-antibody (Lysozyme-Fab) complexes. J. Mol. Biol. 203:527.
    • (1988) J. Mol. Biol. , vol.203 , pp. 527
    • Fischmann, T.1    Souchon, H.2    Riottot, M.M.3    Tello, D.4    Poljak, R.J.5
  • 34
    • 0018860983 scopus 로고
    • Hybridomas cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens
    • Ozato, K., N. Mayer, and D. H. Sachs. 1980. Hybridomas cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens. J. Immunol. 124:533.
    • (1980) J. Immunol. , vol.124 , pp. 533
    • Ozato, K.1    Mayer, N.2    Sachs, D.H.3
  • 37
    • 0028238668 scopus 로고
    • Specificity and flexibility in thymic selection
    • Jameson, S. C., K. A. Hogquist, and M. J. Bevan. 1994. Specificity and flexibility in thymic selection. Nature 369:750.
    • (1994) Nature , vol.369 , pp. 750
    • Jameson, S.C.1    Hogquist, K.A.2    Bevan, M.J.3
  • 38
    • 0028025705 scopus 로고
    • Th2 cell clonal anergy as a consequence of partial activation
    • Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1994. Th2 cell clonal anergy as a consequence of partial activation. J. Exp. Med. 180:1195.
    • (1994) J. Exp. Med. , vol.180 , pp. 1195
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 39
    • 0030056870 scopus 로고    scopus 로고
    • Anergy as a mechanism of peripheral T cell tolerance
    • Quill, H. 1996. Anergy as a mechanism of peripheral T cell tolerance. J. Immunol. 156:1325.
    • (1996) J. Immunol. , vol.156 , pp. 1325
    • Quill, H.1
  • 40
    • 0027205194 scopus 로고
    • Clone-specific T cell receptor antagonists of major histpcompatibility complex class I-restricted cytotoxic T cells
    • Jameson, S. C., F. R. Carbone, and M. J. Bevan. 1993. Clone-specific T cell receptor antagonists of major histpcompatibility complex class I-restricted cytotoxic T cells. J. Exp. Med. 177:1541.
    • (1993) J. Exp. Med. , vol.177 , pp. 1541
    • Jameson, S.C.1    Carbone, F.R.2    Bevan, M.J.3
  • 42
    • 0030745938 scopus 로고    scopus 로고
    • Characterization and quantitation of peptide-MHC complexes produced from hen egg-white lysozyme using a monoclonal antibody
    • Dadaglio, G., C. A. Nelson, M. B. Deck, S. J. Petzold, and E. R. Unanue. 1997. Characterization and quantitation of peptide-MHC complexes produced from hen egg-white lysozyme using a monoclonal antibody. Immunity 6:727.
    • (1997) Immunity , vol.6 , pp. 727
    • Dadaglio, G.1    Nelson, C.A.2    Deck, M.B.3    Petzold, S.J.4    Unanue, E.R.5
  • 43
    • 0028261582 scopus 로고
    • Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103)
    • Reay, P. A., R. M. Kantor, and M. M. Davis. 1994. Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103). J. Immunol. 152:3946.
    • (1994) J. Immunol. , vol.152 , pp. 3946
    • Reay, P.A.1    Kantor, R.M.2    Davis, M.M.3
  • 44
    • 0030852519 scopus 로고    scopus 로고
    • A range of CD4 T cell tolerance: Partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis
    • Akkaraju, S., W. Y. Ho, D. Leong, K. Canaan, M. M. Davis, and C. C. Goodnow. 1997. A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity 7:255.
    • (1997) Immunity , vol.7 , pp. 255
    • Akkaraju, S.1    Ho, W.Y.2    Leong, D.3    Canaan, K.4    Davis, M.M.5    Goodnow, C.C.6
  • 49
    • 0026551703 scopus 로고
    • In vivo and in vitro clonal deletion of double-positive thymocytes
    • Vasquez, N. J., J. Kaye, and S. M. Hedrick. 1992. In vivo and in vitro clonal deletion of double-positive thymocytes. J. Exp. Med. 175:1307.
    • (1992) J. Exp. Med. , vol.175 , pp. 1307
    • Vasquez, N.J.1    Kaye, J.2    Hedrick, S.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.