TCR transgenic mice in which usage of transgenic α- and β-chains is highly dependent on the level of selecting ligand

Journal of Immunology

Volumn 161, Issue 2, 1998, Pages 585-593

  Kersh, Gilbert J ^a   Donermeyer, David L ^a   Frederick, Katherine E ^a   White, J Michael ^a   Hsu, Benjamin L ^a,b   Allen, Paul M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; HEMOGLOBIN; HLA ANTIGEN; LIGAND; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SELECTION; CONTROLLED STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CLONE CELLS; CROSSES, GENETIC; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; H-2 ANTIGENS; LIGANDS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MICE; MICE, INBRED AKR; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SPLEEN; TH1 CELLS; TRANSGENES;

EID: 0032528486     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Mallick, C. A., E. C. Dudley, J. L. Viney, M. J. Owen, and A. C. Hayday. 1993. Rearrangement and diversity of T cell receptor β chain genes in thymocytes: a critical role for the β chain in development. Cell 73:513.
2. Palmer, D. B., A. Hayday, and M. J. Owen. 1993. Is TCR β expression an essential event in early thymocyte development. Immunol. Today 14:460.
3. Mombaerts, P., A. R. Clarke, M. A. Rudnicki, J. Iacomini, S. Itohara, J. J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M. L. Hooper, and S. Tonegawa. 1992. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360:225.
4. Shinkai, Y., S. Koyasu, K.-i. Nakayama, K. M. Murphy, D. Y. Loh, E. L. Reinherz, and F. W. Alt. 1993. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 259:822.
5. Godfrey, D. I., and A. Zlotnik. 1993. Control points in early T-cell development. Immunol. Today 14:547.
6. Dudley, E. C., H. T. Petrie, L. M. Shah, M. J. Owen, and A. C. Hayday. 1994. T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1:83.
7. Groettrup, M., K. Ungewiss, O. Azogui, R. Palacios, M. J. Owen, A. C. Hayday, and H. von Boehmer. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kDa glycoprotein. Cell 75:283.
8. Casanova, J.-L., P. Romero, C. Widmann, P. Kourilsky, and J. L. Maryanski. 1991. T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: Implications for T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174:1371.
9. Davodeau, F., M.-A. Peyrat, F. Romagné, A. Necker, M.-M. Hallet, H. Vié and M. Bonneville. 1995. Dual T cell receptor β chain expression of human T lymphocytes. J. Exp. Med. 181:1391.
10. Padovan, E., C. Giachino, M. Cella, S. Valitutti, O. Acuto, and A. Lanzavecchia. 1995. Normal T lymphocytes can express two different T cell receptor β chains: implications for the mechanism of allelic exclusion. J. Exp. Med. 181:1587.
11. Balomenos, D., R. S. Baldaras, K. P. Mulvany, J. Kaye, D. H. Kono, and A. N. Theofilopoulos. 1995. Incomplete T cell receptor Vβ allelic exclusion and dual Vβ-expressing cells. J. Immunol. 155:3308.
12. Borgulya, P., H. Kishi, Y. Uematsu, and H. von Boehmer. 1992. Exclusion and inclusion of a and β T cell receptor alleles. Cell 69:529.
13. Padovan, E., G. Casorati, P. Dellabona, S. Meyer, M. Brockhaus, and A. Lanzavecchia. 1993. Expression of two T cell receptor α chains: dual receptor T cells. Science 262:422.
14. Zal, T., S. Weiss, A. Mellor, and B. Stockinger. 1996. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc. Natl. Acad. Sci. USA 93:9102.
15. Hardardottir, F., J. L. Baron, and C. A. Janeway, Jr. 1995. T cells with two functional antigen-specific receptors. Proc. Natl. Acad. Sci. USA 92:354.
16. Merkenschlager, M., C. Benoist, and D. Mathis. 1994. Evidence for a single-niche model of positive selection. Proc. Natl. Acad. Sci. USA 91:1169:4.
17. Huesmann, M., B. Scott, P. Kisielow, and H. von Boehmer. 1991. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 66:533.
18. Berg, L. J., G. D. Frank, and M. M. Davis. 1990. The effects of MHC gene dosage and allelic variation on T cell receptor selection. Cell 60:1043.
19. Yelon, D., and L. J. Berg. 1997. Structurally similar TCRs differ in their efficiency of positive selection. J. Immunol. 158:5219.
20. + T cells. J. Exp. Med. 179:1539.
21. Evavold, B. D., S. G. Williams, B. L. Hsu, S. Buus, and P. M. Allen. 1992. Complete dissection of the Hb(64-76) determinant using Th1, Th2 clones, and T cell hybridomas. J. Immunol. 148:347.
22. Hogan, B., F. Costantini, and E. Lacy. 1986. Manipulating the Mouse Embryo. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp. 1-332.
23. Rojo, J. M., and C. A. Janeway, Jr. 1988. The biologic activity of anti-T cell receptor V region monoclonal antibodies is determined by the epitope recognized. J. Immunol. 140:1081.
24. Kearney, J. F., A. Radbruch, B. Liesegang, and K. Rajewsky. 1979. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 123:1548.
25. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1994. Th2 cell clonal anergy as a consequence of partial activation. J. Exp. Med. 180:1195.
26. Kersh, G. J., and P. M. Allen. 1996. Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. J. Exp. Med. 184:1259.
27. Uematsu, Y., S. Ryser, Z. Dembic, P. Borgulya, P. Krimpenfort, A. Berns, H. von Boehmer, and M. Steinmetz. 1988. In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes. Cell 52:831.
28. α immune response gene. Cell 32:745.
29. Alam, S. M., I. N. Crispe, and N. R. J. Gascoigne. 1995. Allelic exclusion of mouse T cell receptor α chains occurs at the time of thymocyte TCR up-regulation. Immunity 3:449.
30. Mombaerts, P., J. Iacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869.
31. Wasserman, R., Y.-S. Li, S. A. Shinton, C. E. Carmack, T. Manser, D. L. Wiest, K. Hayakawa, and R. R. Hardy. 1998. A novel mechanism for B cell repertoire maturation based on response by B cell precursors to Pre-B receptor assembly. J. Exp. Med. 187:259.
32. 2+ thymocytes as post-selection intermediates leading to mature T cells. J. Exp. Med. 173:323.
33. Valitutti, S., S. Müller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
34. Akkaraju, S., W. Y. Ho, D. Leong, K. Canaan, M. M. Davis, and C. C. Goodnow. 1997. A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity 7:255.
35. lck controls allelic exclusion of T-cell receptor β-chain genes. Nature 365: 552.
36. Aifantis, I., J. Buer, H. von Boehmer, and O. Azogui. 1997. Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor β locus. Immunity 7:601.