메뉴 건너뛰기




Volumn 4, Issue 6, 2004, Pages 1145-1156

Signaling multiplex of the epidermal growth factor receptor

Author keywords

Akr; Apoptosis; ATP binding pocket; Cetuximab; Crystal structure; EGFR; EGFR mutations; erbB family; Heterodimer; JAK STAT

Indexed keywords

6 (4 HYDROXYPHENYL) 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; BEVACIZUMAB; CANERTINIB; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; ERLOTINIB; FIBROBLAST GROWTH FACTOR; FLUOROURACIL; FOLINIC ACID; GEFITINIB; IMATINIB; IRINOTECAN; JANUS KINASE 2; LAPATINIB; OXALIPLATIN; PELITINIB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAF PROTEIN; RAS PROTEIN; VASCULOTROPIN RECEPTOR;

EID: 10644253660     PISSN: 14737140     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737140.4.6.1145     Document Type: Review
Times cited : (2)

References (99)
  • 1
    • 0025946824 scopus 로고
    • Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction
    • Aroian RV, Sternberg PW. Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction. Genetics 128, 251-267 (1991).
    • (1991) Genetics , vol.128 , pp. 251-267
    • Aroian, R.V.1    Sternberg, P.W.2
  • 2
    • 0029100254 scopus 로고
    • Inhibition of Drasophila EGF receptor activation by the secreted protein Argos
    • Schweitzer R, Howes R, Smith R, Shilo BZ, Freeman M. Inhibition of Drasophila EGF receptor activation by the secreted protein Argos. Nature 376, 699-702 (1995).
    • (1995) Nature , vol.376 , pp. 699-702
    • Schweitzer, R.1    Howes, R.2    Smith, R.3    Shilo, B.Z.4    Freeman, M.5
  • 3
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19, 183-232 (1995).
    • (1995) Crit. Rev. Oncol. Hematol. , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 5
    • 0023429079 scopus 로고
    • Increased expression of the EGF receptor gene in malignant gliomas is invariably associated with gene amplification
    • Wong AJ, Bigner SH, Bigner DD, Kinzier KW, Hamilton SR, Vogelstein B. Increased expression of the EGF receptor gene in malignant gliomas is invariably associated with gene amplification. Proc. Natl Acad. Sci. 84, 6899-6903 (1987).
    • (1987) Proc. Natl. Acad. Sci. , vol.84 , pp. 6899-6903
    • Wong, A.J.1    Bigner, S.H.2    Bigner, D.D.3    Kinzier, K.W.4    Hamilton, S.R.5    Vogelstein, B.6
  • 6
    • 0026462778 scopus 로고
    • Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor-α
    • Korc M, Chandrasekar B, Yamanaka Y, Friess H, Buchier M, Beger HG. Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor-α. J. Clin. Invest. 90, 1352-1360 (1993).
    • (1993) J. Clin. Invest. , vol.90 , pp. 1352-1360
    • Korc, M.1    Chandrasekar, B.2    Yamanaka, Y.3    Friess, H.4    Buchier, M.5    Beger, H.G.6
  • 7
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 103, 211-225 (2000).
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 8
    • 0031936410 scopus 로고    scopus 로고
    • Specificity within the EGF family/ErbB receptor family signaling network
    • Riese DJ II, Stern DF. Specificity within the EGF family/ErbB receptor family signaling network. Bioessays 20, 41-48 (1998).
    • (1998) Bioessays , vol.20 , pp. 41-48
    • Riese II, D.J.1    Stern, D.F.2
  • 9
    • 0030944455 scopus 로고    scopus 로고
    • ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
    • Graus-Porta D, Beerli RR, Daly JM, Hynes NE. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 16, 1647-1655 (1997).
    • (1997) EMBO J. , vol.16 , pp. 1647-1655
    • Graus-Porta, D.1    Beerli, R.R.2    Daly, J.M.3    Hynes, N.E.4
  • 11
    • 0029074587 scopus 로고
    • Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
    • Miettinen PJ, Berger JE, Meneses J et al. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376, 337-341 (1995).
    • (1995) Nature , vol.376 , pp. 337-341
    • Miettinen, P.J.1    Berger, J.E.2    Meneses, J.3
  • 12
    • 0028884413 scopus 로고
    • Requirement for neuregulin receptor erbB2 in neural and cardiac development
    • Lee KF, Simon H, Chen H, Bates B, Hung MC, Hauser C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378, 394-398 (1995).
    • (1995) Nature , vol.378 , pp. 394-398
    • Lee, K.F.1    Simon, H.2    Chen, H.3    Bates, B.4    Hung, M.C.5    Hauser, C.6
  • 13
    • 0033542381 scopus 로고    scopus 로고
    • Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloaveolar development and lactation
    • Jones FE, Stern DF. Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloaveolar development and lactation. Oncogene 18, 3481-3490 (1999).
    • (1999) Oncogene , vol.18 , pp. 3481-3490
    • Jones, F.E.1    Stern, D.F.2
  • 14
    • 0033523775 scopus 로고    scopus 로고
    • ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation
    • Jones FE, Welte T, Fu XY, Stern DF. ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. J. Cell Biol. 147, 77-87 (1999).
    • (1999) J. Cell Biol. , vol.147 , pp. 77-87
    • Jones, F.E.1    Welte, T.2    Fu, X.Y.3    Stern, D.F.4
  • 15
    • 0027297643 scopus 로고
    • TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
    • Luetteke NC, Qiu TH, Peiffer RL, Oliver P, Smithies O, Lee DC. TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73, 263-278 (1993).
    • (1993) Cell , vol.73 , pp. 263-278
    • Luetteke, N.C.1    Qiu, T.H.2    Peiffer, R.L.3    Oliver, P.4    Smithies, O.5    Lee, D.C.6
  • 16
    • 0027315183 scopus 로고
    • Mice with a null mutation of the TGF-α gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation
    • Mann GB, Fowler KJ, Gabriel A, Nice EC, Williams RL, Dunn AR. Mice with a null mutation of the TGF-α gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 73, 249-261 (1993).
    • (1993) Cell , vol.73 , pp. 249-261
    • Mann, G.B.1    Fowler, K.J.2    Gabriel, A.3    Nice, E.C.4    Williams, R.L.5    Dunn, A.R.6
  • 17
    • 0032472938 scopus 로고    scopus 로고
    • A strain-dependent postnatal neurodegeneration in mice lacking EGF receptor
    • Sibilia M, Steinbach JP, Stingl L, Aguzzi A, Wagner EF. A strain-dependent postnatal neurodegeneration in mice lacking EGF receptor. EMBO J. 17, 719-731 (1998).
    • (1998) EMBO J. , vol.17 , pp. 719-731
    • Sibilia, M.1    Steinbach, J.P.2    Stingl, L.3    Aguzzi, A.4    Wagner, E.F.5
  • 18
    • 0023948728 scopus 로고
    • Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling
    • Lax I, Burgess WH, Bellot F, Ullrich A, Schlessinger J, Givol D. Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling. Mol. Cell Biol. 8, 1831-1834 (1988).
    • (1988) Mol. Cell Biol. , vol.8 , pp. 1831-1834
    • Lax, I.1    Burgess, W.H.2    Bellot, F.3    Ullrich, A.4    Schlessinger, J.5    Givol, D.6
  • 19
    • 0024342417 scopus 로고
    • Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules
    • Lax I, Bellot F, Howk R, Ullrich A, Givol D, Schlessinger J. Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules. EMBO J. 8, 421-427 (1989).
    • (1989) EMBO J. , vol.8 , pp. 421-427
    • Lax, I.1    Bellot, F.2    Howk, R.3    Ullrich, A.4    Givol, D.5    Schlessinger, J.6
  • 20
    • 18644386251 scopus 로고    scopus 로고
    • Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains
    • Ogiso H, Ishitani R, Nureki O et al. Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 110, 775-787 (2002).
    • (2002) Cell , vol.110 , pp. 775-787
    • Ogiso, H.1    Ishitani, R.2    Nureki, O.3
  • 21
    • 0030782410 scopus 로고    scopus 로고
    • Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor
    • Wiesmann C, Fuh G, Christinger HW, Eigenbrot C, Wells JA, de Vos AM. Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor. Cell 91, 695-704 (1997).
    • (1997) Cell , vol.91 , pp. 695-704
    • Wiesmann, C.1    Fuh, G.2    Christinger, H.W.3    Eigenbrot, C.4    Wells, J.A.5    de Vos, A.M.6
  • 22
    • 18644370411 scopus 로고    scopus 로고
    • Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor-α
    • Garrett TPJ, McKern NM, Lou M et al. Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor-α. Cell 110, 763-773 (2002).
    • (2002) Cell , vol.110 , pp. 763-773
    • Garrett, T.P.J.1    McKern, N.M.2    Lou, M.3
  • 23
    • 0031840484 scopus 로고    scopus 로고
    • ErbB-1 and erbB-2 acquire distinct signaling properties dependent upon their dimerization partner
    • Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE. ErbB-1 and erbB-2 acquire distinct signaling properties dependent upon their dimerization partner. Mol. Cell. Biol. 18, 5042-5051 (1998).
    • (1998) Mol. Cell Biol. , vol.18 , pp. 5042-5051
    • Olayioye, M.A.1    Graus-Porta, D.2    Beerli, R.R.3    Rohrer, J.4    Gay, B.5    Hynes, N.E.6
  • 24
    • 0030795612 scopus 로고    scopus 로고
    • The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
    • Alroy I, Yarden Y. The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett. 410, 83-86 (1997).
    • (1997) FEBS Lett. , vol.410 , pp. 83-86
    • Alroy, I.1    Yarden, Y.2
  • 25
    • 0031010495 scopus 로고    scopus 로고
    • Secondary dimerization between members of the epidermal growth factor receptor family
    • Gamett DC, Pearson G, Cerione RA, Friedberg I. Secondary dimerization between members of the epidermal growth factor receptor family. J. Biol. Chem. 272, 12052-12056 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 12052-12056
    • Gamett, D.C.1    Pearson, G.2    Cerione, R.A.3    Friedberg, I.4
  • 26
    • 0037029712 scopus 로고    scopus 로고
    • Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas
    • Hirsch FR, Varella-Garcia M, Franklin WA et al. Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas. Br. J. Cancer 86, 1449-1456 (2002 ).
    • (2002) Br. J. Cancer , vol.86 , pp. 1449-1456
    • Hirsch, F.R.1    Varella-Garcia, M.2    Franklin, W.A.3
  • 27
    • 0029814271 scopus 로고    scopus 로고
    • A hierarchical network of inter-receptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
    • Tzahar E, Waterman H, Chen X et al. A hierarchical network of inter-receptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol. Cell. Biol. 16, 5276-5287 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5276-5287
    • Tzahar, E.1    Waterman, H.2    Chen, X.3
  • 28
    • 1542615081 scopus 로고    scopus 로고
    • Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma
    • Hughes DPM, Thomas DG, Giordano TJ, Baker LH, McDonagh KT. Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma. Cancer Res. 64, 2047-2053 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 2047-2053
    • Hughes, D.P.M.1    Thomas, D.G.2    Giordano, T.J.3    Baker, L.H.4    McDonagh, K.T.5
  • 30
    • 0345135149 scopus 로고    scopus 로고
    • K-ras is an essential gene in the mouse with partial functional overlap with N-ras
    • Johnson L, Greenbaum D, Cichowski K et al. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 11, 2468-2481 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 2468-2481
    • Johnson, L.1    Greenbaum, D.2    Cichowski, K.3
  • 31
    • 0025765803 scopus 로고
    • SH-2 and SH-3 domains: Elements that control interactions of cytoplasmic signaling proteins
    • Koch AC, Anderson D, Moran MF, Ellis C, Pawson T. SH-2 and SH-3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252, 668-674 (1991).
    • (1991) Science , vol.252 , pp. 668-674
    • Koch, A.C.1    Anderson, D.2    Moran, M.F.3    Ellis, C.4    Pawson, T.5
  • 32
    • 0035787526 scopus 로고    scopus 로고
    • Ras activation of the Raf kinase: Tyrosine kinase recruitment of the MAPK cascade
    • Avruch J, Khokhlatchev A, Kyriakis JM et al. Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAPK cascade. Recent Prog. Horm. Res. 56, 127-155 (2001).
    • (2001) Recent Prog. Horm. Res. , vol.56 , pp. 127-155
    • Avruch, J.1    Khokhlatchev, A.2    Kyriakis, J.M.3
  • 33
    • 0037352170 scopus 로고    scopus 로고
    • Involvement of P13K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy
    • Chang F, Lee JT, Navolanic PM et al. Involvement of P13K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17, 590-603 (2003).
    • (2003) Leukemia , vol.17 , pp. 590-603
    • Chang, F.1    Lee, J.T.2    Navolanic, P.M.3
  • 34
    • 0034174516 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the p85 subunit of phosphatidylinositol 3-kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia
    • Martinez-Lorenzo MJ, Anel A, Monleon I et al. Tyrosine phosphorylation of the p85 subunit of phosphatidylinositol 3-kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia. Int. J. Biochem. Cell. Biol. 32, 435-445 (2000).
    • (2000) Int. J. Biochem. Cell Biol. , vol.32 , pp. 435-445
    • Martinez-Lorenzo, M.J.1    Anel, A.2    Monleon, I.3
  • 35
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tio X et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997).
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tio, X.3
  • 36
    • 0030907987 scopus 로고    scopus 로고
    • P13K: Downstream AKTion blocks apoptosis
    • Franke TF, Kaplan DR, Cantley LC. P13K: downstream AKTion blocks apoptosis. Cell 88, 435-437 (1997).
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 37
    • 0032560521 scopus 로고    scopus 로고
    • Evidence insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
    • Scott PH, Brunn GJ, Kohn AD et al. Evidence insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc. Natl. Acad. Sci. 95, 7772-7777 (1998).
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 7772-7777
    • Scott, P.H.1    Brunn, G.J.2    Kohn, A.D.3
  • 38
    • 0034652392 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
    • Jiang B-H, Zheng JZ, Aoki M, Vogt PK. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl Acad. Sci. 97, 1749-1753 (2000).
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 1749-1753
    • Jiang, B.-H.1    Zheng, J.Z.2    Aoki, M.3    Vogt, P.K.4
  • 40
    • 0038711502 scopus 로고    scopus 로고
    • Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells
    • Ahonen TJ, Xie J, LeBaron MJ et al. Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells. J. Biol. Chem. 278, 27287-27292 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 27287-27292
    • Ahonen, T.J.1    Xie, J.2    LeBaron, M.J.3
  • 41
    • 0035162703 scopus 로고    scopus 로고
    • Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking
    • Burke P, Schooler K, Wiley HS. Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol. Biol. Cell 12, 1897-1910 (2001).
    • (2001) Mol. Biol. Cell , vol.12 , pp. 1897-1910
    • Burke, P.1    Schooler, K.2    Wiley, H.S.3
  • 42
    • 0029742067 scopus 로고    scopus 로고
    • Quantitative estimation of epidermal growth factor receptor and c-erb-2 in human breast cancer
    • Robertson KW, Reeves JR, Smith G et al. Quantitative estimation of epidermal growth factor receptor and c-erb-2 in human breast cancer. Cancer Res. 56, 3823-3830 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 3823-3830
    • Robertson, K.W.1    Reeves, J.R.2    Smith, G.3
  • 43
    • 0027524082 scopus 로고
    • Oncogenes in head and neck cancer
    • Irish JC, Bernstein A. Oncogenes in head and neck cancer. Laryngoscope 103, 42-52 (1993).
    • (1993) Laryngoscope , vol.103 , pp. 42-52
    • Irish, J.C.1    Bernstein, A.2
  • 44
    • 0028937815 scopus 로고
    • Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype
    • Fontanini G, Vignati S, Bigini D et al. Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype. Eur. J. Cancer 31A, 178-183 (1995).
    • (1995) Eur. J. Cancer , vol.31 A , pp. 178-183
    • Fontanini, G.1    Vignati, S.2    Bigini, D.3
  • 45
    • 0026548240 scopus 로고
    • Structural alterations of the epidermal growth factor receptor gene in human gliomas
    • Wong AJ, Ruppert, Bigner SH et al. Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc. Natl Acad. Sci. 89, 2965-2969 (1992).
    • (1992) Proc. Natl. Acad. Sci. , vol.89 , pp. 2965-2969
    • Wong, A.J.1    Ruppert, A.2    Bigner, S.H.3
  • 46
    • 0024355092 scopus 로고
    • Autocrine interaction between TGF-α and the EGF-receptor: Quantitative requirements for induction of the malignant phenotype
    • Di Marco E, Pierce JH, Fleming TP et al. Autocrine interaction between TGF-α and the EGF-receptor. quantitative requirements for induction of the malignant phenotype. Oncogene 4, 831-838 (1992).
    • (1992) Oncogene , vol.4 , pp. 831-838
    • Di Marco, E.1    Pierce, J.H.2    Fleming, T.P.3
  • 47
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinbert RA. The hallmarks of cancer. Cell 100, 57-70 (2000).
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinbert, R.A.2
  • 48
    • 0018069488 scopus 로고
    • Growth factors produced by sarcoma virus-transformed cells
    • Todaro GJ, De Larco JE. Growth factors produced by sarcoma virus-transformed cells. Cancer Res. 38, 4147-4154 (1978).
    • (1978) Cancer Res. , vol.38 , pp. 4147-4154
    • Todaro, G.J.1    De Larco, J.E.2
  • 50
    • 0038626211 scopus 로고    scopus 로고
    • Tumor response to radiotherapy regulated by endothelial cell apoptosis
    • Garcia-Barros M, Paris F, Cordon-Cardo C et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300, 1155-1159 (2003).
    • (2003) Science , vol.300 , pp. 1155-1159
    • Garcia-Barros, M.1    Paris, F.2    Cordon-Cardo, C.3
  • 51
    • 0034212763 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
    • Bruns CJ, Solorzano, CC, Harbison MT et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 60, 2926-2935 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 2926-2935
    • Bruns, C.J.1    Solorzano, C.C.2    Harbison, M.T.3
  • 52
    • 0034650744 scopus 로고    scopus 로고
    • Oncogenes and tumor angiogenesis: Differential modes of vascular endothelial growth factor upregulation in ras-transformed epithelial cells and fibroblasts
    • Rak J, Mitsuhashi Y, Sheehan C et al. Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor upregulation in ras-transformed epithelial cells and fibroblasts. Cancer Res. 60, 490-498 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 490-498
    • Rak, J.1    Mitsuhashi, Y.2    Sheehan, C.3
  • 53
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and erbB-2/neu receptor tyrosine kinases downregulate vascular endothelial growth factor production by tumor cells in vitro and in vivo
    • Viloria Petit AM, Rak J, Hung M-C et al. Neutralizing antibodies against epidermal growth factor and erbB-2/neu receptor tyrosine kinases downregulate vascular endothelial growth factor production by tumor cells in vitro and in vivo. Am. J. Pathol. 151, 1523-1530 (1997).
    • (1997) Am. J. Pathol. , vol.151 , pp. 1523-1530
    • Viloria Petit, A.M.1    Rak, J.2    Hung, M.-C.3
  • 54
    • 0033119572 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase
    • Wang D, Su Huang H-J, Kazlauskas A, Cavenee WK. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res. 59, 1464-1472 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 1464-1472
    • Wang, D.1    Su Huang, H.-J.2    Kazlauskas, A.3    Cavenee, W.K.4
  • 55
    • 0034929216 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) upregulates bcl-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells
    • Pidgeon GP, Barr MP, Harmey JH, Foley DA, Bouchier-Hayes DJ. Vascular endothelial growth factor (VEGF) upregulates bcl-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells. Br. J. Cancer 85, 273-278 (2001).
    • (2001) Br. J. Cancer , vol.85 , pp. 273-278
    • Pidgeon, G.P.1    Barr, M.P.2    Harmey, J.H.3    Foley, D.A.4    Bouchier-Hayes, D.J.5
  • 56
    • 0032403016 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an anti-apoptotic factor
    • Katoh O, Takahashi T, Oguri T et al. Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an anti-apoptotic factor. Cancer Res. 58, 5565-5569 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 5565-5569
    • Katoh, O.1    Takahashi, T.2    Oguri, T.3
  • 57
    • 0037085765 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy
    • Dias S, Choy M, Alitalo K, Rafii S. Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood 99, 2179-2184 (2002).
    • (2002) Blood , vol.99 , pp. 2179-2184
    • Dias, S.1    Choy, M.2    Alitalo, K.3    Rafii, S.4
  • 59
    • 0027511735 scopus 로고
    • APO-1 mediate apoptosis or proliferation in human chronic B lymphocytic leukemia: Correlation with bcl-2 oncogene expression
    • Mapara MY, Bargou R, Zugck C et al. APO-1 mediate apoptosis or proliferation in human chronic B lymphocytic leukemia: correlation with bcl-2 oncogene expression. Eur. J. Immunol. 23, 702-708 (1993).
    • (1993) Eur. J. Immunol. , vol.23 , pp. 702-708
    • Mapara, M.Y.1    Bargou, R.2    Zugck, C.3
  • 61
    • 0028944988 scopus 로고
    • Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2
    • Sorkin A, McKinsey T, Shih W, Kirchhausen T, Carpenter G. Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2. J. Biol. Chem. 270, 619-625 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 619-625
    • Sorkin, A.1    McKinsey, T.2    Shih, W.3    Kirchhausen, T.4    Carpenter, G.5
  • 62
    • 0008486660 scopus 로고
    • Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation
    • Sunada H, Magun BE, Mendelsohn J, MacLeod CL. Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation. Proc. Natl Acad. Sci. 83, 3825-3829 (1986).
    • (1986) Proc. Natl. Acad. Sci. , vol.83 , pp. 3825-3829
    • Sunada, H.1    Magun, B.E.2    Mendelsohn, J.3    MacLeod, C.L.4
  • 63
    • 0029670014 scopus 로고    scopus 로고
    • 1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody
    • 1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene 12, 1397-1403 (1996).
    • (1996) Oncogene , vol.12 , pp. 1397-1403
    • Wu, X.1    Rubin, M.2    Fan, Z.3
  • 64
    • 0034895886 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer
    • Shin DM, Donato NJ, Cooper M et al. Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer. Clin. Cancer Res. 7, 1204-1213 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1204-1213
    • Shin, D.M.1    Donato, N.J.2    Cooper, M.3
  • 65
    • 0037862765 scopus 로고    scopus 로고
    • Cetuximab (C225) alone or in combination with irinotecan (CPT- 11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan refractory metastatic colorectal cancer (MCRC)
    • (Abstract 1012)
    • Cunningham D, Humbler Y, Siena S et al. Cetuximab (C225) alone or in combination with irinotecan (CPT- 11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan refractory metastatic colorectal cancer (MCRC). Proc. Am. Sec. Clin. Oncol. 22 (2003) (Abstract 1012).
    • (2003) Proc. Am. Sec. Clin. Oncol. , vol.22
    • Cunningham, D.1    Humbler, Y.2    Siena, S.3
  • 66
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ Sr, Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J. Clin. Oncol. 22, 1201-1208 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 67
    • 0001407137 scopus 로고    scopus 로고
    • Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFr)
    • (Abstract 536)
    • Rosenberg AH, Loehrer PJ, Needle MN, Waksal H, Hollywood E. Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFr). Proc. Am. Soc. Clin. Oncol. 21 (2002) (Abstract 536).
    • (2002) Proc. Am. Soc. Clin. Oncol. , pp. 21
    • Rosenberg, A.H.1    Loehrer, P.J.2    Needle, M.N.3    Waksal, H.4    Hollywood, E.5
  • 68
    • 0035254521 scopus 로고    scopus 로고
    • Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation
    • Harari PM, Huang SM. Head and neck cancer as a clinical model for molecular targeting of therapy: combining EGFR blockade with radiation. Int. J. Radiat. Oncol. Biol. Phys. 49, 427-433 (2001).
    • (2001) Int. J. Radiat. Oncol. Biol. Phys. , vol.49 , pp. 427-433
    • Harari, P.M.1    Huang, S.M.2
  • 69
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small cell lung cancer
    • Fukuoka M, Yano S, Giaccone G et al. Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small cell lung cancer. J. Clin. Oncol. 21, 2237-2246 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 70
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • Kris MG, Natale RB, Herbst RS et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 290, 2149-2158 (2003).
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 71
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small cell lung cancer: A Phase III trial-INTACT 1
    • Giaccone F, Herbst RS, Manegold C et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small cell lung cancer: a Phase III trial-INTACT 1. J. Clin. Oncol. 22,777-784 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 777-784
    • Giaccone, F.1    Herbst, R.S.2    Manegold, C.3
  • 72
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small cell lung cancer: A Phase III trial-INTACT 2
    • Herbst RS, Giaccone G, Schiller JH et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small cell lung cancer: a Phase III trial-INTACT 2. J. Clin. Oncol. 22, 785-794 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3
  • 73
    • 5644303684 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1st line or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial
    • Abstract 7022)
    • Shepherd FA, Pereira J, Ciuleanu TE et al. A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1st line or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial. Proc. Am. Soc. Clin. Oncol. 22 (2004) (Abstract 7022).
    • (2004) Proc. Am. Soc. Clin. Oncol. , pp. 22
    • Shepherd, F.A.1    Pereira, J.2    Ciuleanu, T.E.3
  • 74
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher T, Cartwright J et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350, 2335-2342 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, T.2    Cartwright, J.3
  • 75
    • 0034235955 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockage by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice
    • Overholser JP, Prewett MC, Hooper AT, Waksal HW, Hicklin DJ. Epidermal growth factor receptor blockage by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice. Cancer 89, 74-82 (2000).
    • (2000) Cancer , vol.89 , pp. 74-82
    • Overholser, J.P.1    Prewett, M.C.2    Hooper, A.T.3    Waksal, H.W.4    Hicklin, D.J.5
  • 76
    • 0034489116 scopus 로고    scopus 로고
    • Paclitaxel enhances the effects of the anti-epidermal growth factor receptor antibody monoclonal antibody Imclone C225 in mice with metastatic human bladder transitional cell carcinoma
    • Inoue K, Slaton JW, Perrotte P et al. Paclitaxel enhances the effects of the anti-epidermal growth factor receptor antibody monoclonal antibody Imclone C225 in mice with metastatic human bladder transitional cell carcinoma. Clin. Cancer Res. 6, 4874-4884 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4874-4884
    • Inoue, K.1    Slaton, J.W.2    Perrotte, P.3
  • 77
    • 0023948602 scopus 로고
    • Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts
    • Humphrey PA, Wong AJ, Vogelstein B et al. Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. Cancer Res. 48, 2231-2238 (1988).
    • (1988) Cancer Res. , vol.48 , pp. 2231-2238
    • Humphrey, P.A.1    Wong, A.J.2    Vogelstein, B.3
  • 78
    • 0025114687 scopus 로고
    • Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
    • Sugawa N, Ekstrand AJ, James CD, Collins VP. Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc. Natl Acad. Sci. 87, 8602-8606 (1990).
    • (1990) Proc. Natl. Acad. Sci. , vol.87 , pp. 8602-8606
    • Sugawa, N.1    Ekstrand, A.J.2    James, C.D.3    Collins, V.P.4
  • 79
    • 0028800035 scopus 로고
    • Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors
    • Moscatello DK, Holgado-Madruga M, Godwin AK et al. Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors. Cancer Res. 55, 5536-5539 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 5536-5539
    • Moscatello, D.K.1    Holgado-Madruga, M.2    Godwin, A.K.3
  • 80
    • 14444288522 scopus 로고    scopus 로고
    • The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
    • Su Huang HJ, Nagane M, Klingbeil CK et al. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J. Biol. Chem. 272, 2927-2935 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 2927-2935
    • Su Huang, H.J.1    Nagane, M.2    Klingbeil, C.K.3
  • 81
    • 0025777103 scopus 로고
    • Internalization and downregulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminus tyrosines
    • Helin K, Beguinot L. Internalization and downregulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminus tyrosines. J. Biol. Chem. 266, 8363-8368 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 8363-8368
    • Helin, K.1    Beguinot, L.2
  • 82
    • 0035893560 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo
    • Moulder SL, Yakes FM, Muthuswamy SK, Bianco R, Simpson FJ, Arteaga CL. Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res. 61, 8887-8895 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 8887-8895
    • Moulder, S.L.1    Yakes, F.M.2    Muthuswamy, S.K.3    Bianco, R.4    Simpson, F.J.5    Arteaga, C.L.6
  • 83
    • 0029162564 scopus 로고
    • Heregulin-dependent regulation of heR2/neu oncogenic signaling by heterodimerization with heR3
    • Wallasch C, WeiB, Niederfellner G, Jallal B, Issing W, Ullrich A. Heregulin-dependent regulation of heR2/neu oncogenic signaling by heterodimerization with heR3. EMBO J. 14, 4267-4275 (1995).
    • (1995) EMBO J. , vol.14 , pp. 4267-4275
    • Wallasch, C.1    Wei, B.2    Niederfellner, G.3    Jallal, B.4    Issing, W.5    Ullrich, A.6
  • 84
    • 0029053716 scopus 로고
    • Co-operative signaling of erbB3 and erbB2 in neoplastic transformation and human mammary carcinomas
    • Alimandi M, Romano A, Curia MC et al. Co-operative signaling of erbB3 and erbB2 in neoplastic transformation and human mammary carcinomas. Oncogene 10, 1813-1821 1995).
    • (1995) Oncogene , vol.10 , pp. 1813-1821
    • Alimandi, M.1    Romano, A.2    Curia, M.C.3
  • 85
    • 0029912203 scopus 로고    scopus 로고
    • All erbB receptors other than the epidermal growth factor receptor are endocytosis impaired
    • Baulida J, Kraus MH, Alimandi M, Di Fiore PP, Carpenter G. All erbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J. Biol. Chem. 271, 5251-5257 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 5251-5257
    • Baulida, J.1    Kraus, M.H.2    Alimandi, M.3    Di Fiore, P.P.4    Carpenter, G.5
  • 86
    • 0025342623 scopus 로고
    • Epidermal growth factor and its receptors in human pancreatic carcinoma
    • Chen YF, Pan GZ, Hou X et al. Epidermal growth factor and its receptors in human pancreatic carcinoma. Pancreas 5, 278-283 (1990).
    • (1990) Pancreas , vol.5 , pp. 278-283
    • Chen, Y.F.1    Pan, G.Z.2    Hou, X.3
  • 87
    • 37049183697 scopus 로고
    • Human breast cancer correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG et al. Human breast cancer correlation of relapse and survival with amplification of the HER-2/ neu oncogene. Science 235, 177-182 (1987).
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 89
    • 0034282556 scopus 로고    scopus 로고
    • Extracellular domains drive homo- but not hereto-dimerization of erbB receptors
    • Ferguson KM, Darling PJ, Mohan MJ, Macatee TL, Lemmon MA. Extracellular domains drive homo- but not hereto-dimerization of erbB receptors. EMBO J. 19, 4632-4643 (2000).
    • (2000) EMBO J. , vol.19 , pp. 4632-4643
    • Ferguson, K.M.1    Darling, P.J.2    Mohan, M.J.3    Macatee, T.L.4    Lemmon, M.A.5
  • 90
    • 0030762433 scopus 로고    scopus 로고
    • A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells
    • Gangarosa LM, Sizemore N, Graves-Deal R, Oldham SM, Der CJ, Coffey RJ. A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of rat intestinal epithelial cells. J. Biol. Chem. 272, 18926-18931 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 18926-18931
    • Gangarosa, L.M.1    Sizemore, N.2    Graves-Deal, R.3    Oldham, S.M.4    Der, C.J.5    Coffey, R.J.6
  • 91
    • 0028146767 scopus 로고
    • A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity
    • Nishikawa R, Ji X-D, Harmon RC et al. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc. Natl Acad. Sci. 91, 7727-7731 (1994).
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 7727-7731
    • Nishikawa, R.1    Ji, X.-D.2    Harmon, R.C.3
  • 92
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G-protein coupled receptors requires metalloproteinase cleavage of proHB-EGF
    • Prenzel N, Zwick E, Daub H et al. EGF receptor transactivation by G-protein coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402, 884-888 (1999).
    • (1999) Nature , vol.402 , pp. 884-888
    • Prenzel, N.1    Zwick, E.2    Daub, H.3
  • 93
    • 0036596352 scopus 로고    scopus 로고
    • EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of human carcinoma
    • Liu D, Aguirre Ghiso JA, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of human carcinoma. Cancer Cell 1, 445-457 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 445-457
    • Liu, D.1    Aguirre Ghiso, J.A.2    Estrada, Y.3    Ossowski, L.4
  • 94
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 95
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R, Bell DW, Haber DA, Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305, 1163-1167 (2004).
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 96
    • 0034891890 scopus 로고    scopus 로고
    • Chromosome 7 aneusomy. A marker for metastatic melanoma? Expression of the epidermal growth factor receptor gene and chromosome 7 aneusomy in nevi, primary malignant melanomas and metastases
    • Udari M, Utikal J, Krahn GM, Peter RU. Chromosome 7 aneusomy. A marker for metastatic melanoma? Expression of the epidermal growth factor receptor gene and chromosome 7 aneusomy in nevi, primary malignant melanomas and metastases. Neoplasia 3, 245-254 (2001).
    • (2001) Neoplasia , vol.3 , pp. 245-254
    • Udari, M.1    Utikal, J.2    Krahn, G.M.3    Peter, R.U.4
  • 97
    • 0030990517 scopus 로고    scopus 로고
    • Influence of the host microenvironment on the clonal selection of human colon carcinoma cells during primary tumor growth and metastasis
    • Singh RK, Tsan R, Radinsky R. Influence of the host microenvironment on the clonal selection of human colon carcinoma cells during primary tumor growth and metastasis. Clin. Exp. Metastasis 15, 140-150 (1997).
    • (1997) Clin. Exp. Metastasis , vol.15 , pp. 140-150
    • Singh, R.K.1    Tsan, R.2    Radinsky, R.3
  • 98
    • 0035895106 scopus 로고    scopus 로고
    • Restoration of sensitivity to STI571 in STI571-resistant chronic myeloid leukemia cells
    • Tipping AJ, Mahon FX, Lagarde V, Goldman JM, Melo JV. Restoration of sensitivity to STI571 in STI571-resistant chronic myeloid leukemia cells. Blood 98, 3864-3867 (2001).
    • (2001) Blood , vol.98 , pp. 3864-3867
    • Tipping, A.J.1    Mahon, F.X.2    Lagarde, V.3    Goldman, J.M.4    Melo, J.V.5
  • 99
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • Branford S, Rudzki Z, Walsh S et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 102, 276-283 (2003).
    • (2003) Blood , vol.102 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.