Quantitative estimation of epidermal growth factor receptor and c- erbB-2 in human breast cancer

Cancer Research

Volumn 56, Issue 16, 1996, Pages 3823-3830

  Robertson, Kevin W ^a   Reeves, Jonathan R ^a   Smith, Gerard ^a   Keith, W Nicol ^b   Ozanne, Bradford W ^b   Cooke, Timothy G ^a   Stanton, Peter D ^a  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; EPIDERMAL GROWTH FACTOR RECEPTOR; ONCOPROTEIN;

ARTICLE; BREAST CANCER; CELL CYCLE; CELL KINETICS; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ONCOGENE C ERB; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; BREAST; BREAST NEOPLASMS; FEMALE; GENE AMPLIFICATION; GENES, ERBB-2; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MIDDLE AGED; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN;

EID: 0029742067     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Sainsbury, J. R. C., Farndon, J. R , Sherbet, G. V., and Harris, A L. Epidermal growth factor receptors and oestrogen receptors in human breast cancer Lancet, 1: 364-366, 1985.
2. Sainsbury, J R. C , Farndon, J R , Needham, G. K., Malcolm, A. J., and Harris, A. L. Epidermal growth factor receptor status as predictor of early recurrence of and death from breast cancer. Lancet, 1: 1398-1402, 1987
3. Harris, A L , Nicholson, S., Sainsbury, J. R. C , Farndon, J., and Wright, C. Epidermal growth factor receptors in breast cancer: association with early relapse and death, poor response to hormones and interaction with neu. J. Steroid Biochem , 34: 123-131, 1989.
4. Klijn, J G M , Berns, P M. J. J , Schmitz, P. I. M., and Foekens, J A The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients. Endocr. Rev , 13: 3-17, 1992.
5. Koenders, P G , Faverly, D , Beex, L V A M , Bruggink, E. D. M., Kienhuis, C. B. M., and Benraad, T. J Epidermal growth factor receptors in human breast cancer a plea for standardisation of assay methodology. Eur. J. Cancer, 28, 693-697, 1992.
6. Slamon, D J., Clark, G M , Wong, S. G., Levin, W J., Ullrich, A . and McGuire, W. L. Human breast cancer, correlation of relapse and survival with amplification of the HER2/neu proto-oncogene in human breast and ovarian cancer. Science (Washington DC), 235, 177-182, 1987
7. Slamon, D. J , Godolphin, W , Jones, L. A , Holt, J A , Wong, S G , Keith, D. E., Levin, J. W , Stuart, S G., Udove, J., Ullrich, A., and Press, F. M. Studies of the HER/neu-2 proto-oncogene in the human breast and ovarian cancer Science (Washington DC), 244: 707-712, 1989
8. Gullick, W. J. The role of epidermal growth factor and the c-erbB-2 protein in breast cancer Int J. Cancer Suppl., 5: 55-61, 1990
9. Earp, H S., Dawson, T. L., Li, X., and Lu, H Heterodimerisation and functional interaction between EGF receptor family members: a new signalling paradigm with implications for breast cancer research. Breast Cancer Res Treat., 35: 115-132, 1995.
10. Toi, M., Tominaga, T., Osaki, A , and Toge, T. Role of epidermal growth factor receptor expression in primary breast cancer results of a biochemical study and an immunocytochemical study. Breast Cancer Res. Treat, 29: 51-58, 1994.
11. Nicholson, R. I., McClelland, R. A., Finlay, P , Eaton, C. L., Gullick, W. J., Dixon, A. R , Robertson, J. F. R., Ellis, I. O., and Blamey, R. W. Relationship between EGF-R, c-erbB-2protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity. Eur. J Cancer, 29: 1018-1023, 1993.
12. Shretha, P., Yamada, K , Wada, T., Maeda, S., Watatani, M., Yasutomi, M., Takagi, H., and Mori, M. Proliferating cell nuclear antigen in breast lesions: correlation of C-erbB-2 oncoprotein and EGF receptor and its clinicopathological significance in breast cancer. Virchows Arch. A Pathol Anat. Histol , 421: 193-202, 1992.
13. Ji, H , Lipponen, P., Aaltomaa, S., Syrjanen, S , and Syrjanen, K. c-erB-2 oncogene related to p53 expression, cell proliferation and prognosis in breast cancer. Anticancer Res., 13: 1147-1152, 1993.
14. Kreipe, H., Feist, H., Fischer, L , Felgner, J., Heidorn, K., Mettler, L., and Parwaresch, R. Amplification of c-myc but not of c-erB-2 is associated with high proliferate capacity in breast cancer. Cancer Res., 53: 1956-1961, 1993.
15. Sirvent, J. J., Santafe, M , Salvado, M. T., Alvaro, T., Raventos, A , and Palacios, J. Hormonal receptors, cell proliferation fraction (Ki-67) and c-erbB-2 amplification in breast cancer. Relationship between differentiation degree and axillary lymph node metastases. Histol. Histopathol., 9, 563-570, 1994.
16. Gasparini, G., Bevilacqua, P. Pozza, F., Meli, S., Boracchi, P., Marubini, E., and Sainsbury, J. R. C. Value of epidermal growth factor status compared with growth fraction and other factors for prognosis in early breast cancer Br. J. Cancer, 66: 970-976, 1992.
17. Elston, C. W , and Ellis, I. O. Pathological prognostic factors in breast cancer: I The value of histological grade in breast cancer experience from a large study with long term follow up. Histopathology, 19 403-410, 1991
18. Hendler, F J , and Ozanne, B. W. Human squamous cell lung cancers express increased epidermal growth factors. J. Clin Invest., 74: 647-651, 1984
19. Stanton, P. D., Richards, S., Reeves, J., Nikolic, M., Edington, K , Clark, L., Robertson, G., Souter, D , Mitchell, R., Hendler, F. J., Cooke, T., Parkinson, E K , and Ozanne, B. W. Epidermal growth factor receptor expression by human squamous cell carcinomas of the head and neck, cell lines and xenographs. Br. J Cancer, 70: 427-433, 1994.
20. Waterfield, M. D., Mayes, E. L. V., Stroobant, P., Bennet, P. L. P., Young, S., Goodfellow, P. N., Banting, G. S , and Ozanne, B. W Monoclonal antibody to the human epidermal growth factor receptor. J. Cell Biochem., 20: 149-161, 1982.
21. Styles, J. M., Harrison, S., Gusterson, B. A , and Dean, C. J. Rat monoclonal antibodies to the external domain of the product of the c-erbB-2 proto-oneogene. Int. J. Cancer, 45: 320-324, 1990.
22. Harlow, E , and Lane, D. (eds) Antibodies: A Laboratory Manual. Cold Spring Harbor, NY. Cold Spring Harbor Laboratory, 1988.
23. Murphy, D S. M , McHardy, P , Coutts, J., Mallon, E. A., George, D., Kaye, S. B., Brown, R., and Keith, W. N Interphase cytogenetic analysis of erbB2 and topoIIα co-amplification in invasive breast cancer and polysomy of chromosome 17 in ductal carcinoma in situ. Int. J. Cancer, 64: 18-26, 1995.
24. Begg, A. C., McNally, N., Shrieve, D. C., and Karcher, H. A method to measure the duration of DNA synthesis and the potential doubling time from a single sample. Cytometry, 6: 620-626, 1985.
25. Stanton, P. D., Foster, G., Smith, D., and Cooke, T. G. Cell kinetics in vivo of human breast cancer. Br. J Surg , 83: 98-102, 1996.
26. Dittadi, R., Donisi, P. M., Brazzale, A., Cappellozza, L., Bruscagnin, G., and Gion, M. Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue Br J Cancer, 67: 7-9, 1993.
27. Chrysogelos, S. A., and Dickson, R. B. EGF receptor expression, regulation, and function in breast cancer. Breast Cancer Res. Treat., 29: 29-40, 1994
28. Rajkumar, T., and Gullick, W. J. The type I growth factors in human breast cancer. Breast Cancer Res. Treat., 29: 3-9, 1994.
29. Ozawa, S., Ueda, M , Ando, N., Abe, O , and Shimizu, N Epidermal growth factor receptors in cancer tissues of oesophagus, lung, pancreas, colorectum, breast and stomach Jpn. J. Cancer Res., 79: 1201-1207, 1988
30. Parkes, H C., Lillicrop, K , Howell, A., and Craig, R. K. c-erb-B2 mRNA expression in human breast tumours: comparison with c-erb-B2 DNA amplification and correlation with prognosis Br. J. Cancer, 61: 39-45, 1990.
31. Kraus, M. H , Popescu, N C., Amsbaugh, C., and King, C. R. Overexpression of the EGF receptor-related proto-oncogene c-erbB-2 in human mammary tumour cell lines by different molecular mechanisms EMBO J., 6: 605-610, 1987.
32. Yarden, Y , and Schlessinger, J Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor. Biochemistry, 26: 1443-1451, 1987
33. neu protein and EGF receptor modulates EGF receptor function Cell, 61 1339-1347, 1990.
34. Lee, J , Dull, T. J., Lax, I., Schlessinger, J , and Ullrich. A HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor EMBO J., 8: 167-173, 1989.
35. Lehvaslaiho, H, Lehtola, L., Sistonen, L., and Alitalio, K. A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation. EMBO J., 8: 159-166, 1989.
36. Davidson, E. K. Carcinoma in the mammary lobule and its origin. Edinb. Med. J , XL: 57-82, 1933.
37. Wellings, S. R. Development of human breast cancer. Adv. Cancer Res., 31: 287-314, 1980.
38. Charpin, C., Devictor, B., Bonnier, P , Andrac, L., Lavaut, M , Allasia, C., and Piana, L. Epidermal growth factor receptor in breast cancer, correlation of quantitative immunocytochemical assays to prognostic factors Breast Cancer Res. Treat , 25: 203-210, 1993
39. Gasparini, G., Reitano, M , Bevilaqua, P., Meli, S., Pozza, F., and Santini, G. Relationship of the epidermal growth factor receptor to the growth fraction (KI-67 antibody) and the flow cytometric S-phase as cell kinetics parameters, in human mammary carcinomas. Anticancer Res , 11: 1597-1604, 1991.
40. Walker, R A., and Camplejohn, R. S. DNA flow cytometry of human breast carcinomas and its relationship to transferrin and epidermal growth factor receptors. J. Pathol., 150: 37-42, 1986
41. Minckwitz, G., Kaufmann, H., Schmid, H., Goerttler, K., and Bastert, G. Epidermal growth factor receptor and S-phase fraction as prognosticator combination in node negative primary breast cancer. Breast: 2, 229-233, 1993
42. Borg, A , Baldetorp, B., Ferno, M., Killander, D., Olsson, H., and Sigurdsson, H. ERBB2 amplification in breast cancer with a high rate of proliferation. Oncogene, 6: 137-143, 1991.
43. O'Reilly, S. M., Barnes, D. M., Camplejohn, R. S., Bartkova, J., Gregory, W . M., and Richards, M. A. The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer. Br. J. Cancer, 63: 444-446, 1991.
44. Poller, D. N., Galea, M., Pearson, D , Bell, J., Gullick, W. J., Elston, C. W., Blamey, R. W , and Ellis, I. O. Nuclear and flow cytometric characteristics associated with overexpression of the c-erbB-2 oncoprotein in breast carcinoma Breast Cancer Res. Treat., 20: 3-10, 1991.
45. Pavelic, Z. P , Pavelic, L., Lower, E. E , Gapany, M , Gapany, S , Barker, E. A , and Preisler, H. D. c-myc, c-erbB-2, and Ki-67 expression in normal breast tissue and in invasive and noninvasive breast carcinoma. Cancer Res., 52: 2597-2602, 1992.
46. Meyer, J S , Koehm, S. L , Hughes, J. M., Higa, E., Wittliff, J. L , Lagos, J. A., and Manes, J. L. Bromodeoxyuridine labeling for S-phase measurement in breast carcinoma. Cancer (Phila.), 71: 3531-3540, 1993.
47. Lloveras, B., Edgerton, S., and Thor, A. D. Evaluation of in vitro bromodeoxyuridine labeling of breast carcinomas with the use of a commercial kit. Am. J. Clin. Pathol., 95: 41-47, 1991.
48. Nicholson, R I., McClelland, R. A., Gee, J M. W., Manning, D. L., Cannon, P., Robertson, J. F. R., Ellis, I. O., and Blamey, R. W Epidermal growth factor receptor expression in breast cancer: association with response to endocrine therapy. Breast Cancer Res. Treat., 29: 117-125, 1994.
49. Klijn, J. G M , Berns, E. M. J. J., and Foekens, J. A. Prognostic factors and response to therapy in breast cancer. Cancer Surv., 18: 165-198, 1993.
50. Seeger, R. C., Brodeur, G. M., Stather, H , Dalton, A., Siagel, S. E., Wong, K. Y., and Hammond, D. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl. J. Med , 313: 1111-1116, 1985.
51. Barnes, D. M., Meyer, J S , Gonzalez, J. G., Gullick, W. J., and Millis, R. R. Relationship between c-erb-B2 immunoreactivity and thymidine labelling index in breast carcinoma in situ Breast Cancer Res. Treat., 18: 11-17, 1991.
52. Dickson, R B , and Paik, S. Regulation of proliferation and differentiation of normal and malignant breast: new factors and neu paradoxes. Breast, 2: 83-86, 1993.
53. Bargmann, C I., and Weinberg, R. A. Oncogenic activation of the neu encoded receptor protein by point mutation and deletion EMBO J., 7: 2043-2052, 1988.
54. Peirce, J. H., Arnstein, P., DiMarco, E., Artrip, J., Kraus, M. H., Lonardo, F., Di Fiore, P. P., and Aaronson, A Oncogenic potential of erbB-2 in human mammary epithelial cells. Oncogene, 6: 1189-1194, 1991.
55. Lemoine, N. R., Staddon, S., Dickson, C., Barnes, D. M., and Gullick, W. J. Absence of activating transmembrane mutations in the c-erb-B2 proto-oncogene in human breast cancer. Oncogene, 5: 237-239, 1989
56. Harris, R. A., Hiles, I D., Page, M. J., and O'Hare, M. J. The induction of apoptosis in human mammary luminal epithelial cells by expression of activated c-neu and its abrogation by glucocorticoids Br. J Cancer, 72: 386-392, 1995.
57. Wright, C., Nicholson, S , Angus, B , Sainsbury, J. R. C., Farndon, J., Cairns, J., Harris, A. L., and Horne, C H. W. Relationship between c-erbB-2 protein product expression and response to endocrine therapy in advanced breast cancer Br. J Cancer, 65: 118-121, 1992.
58. Gusterson, B A., Gelber, R. D., Goldhirsch, A., Price, K. N , Save-Soderborgh, J., Anbazhagan, R., Styles, J , Rudenstam, C-M., Golough, R., Reed, R., Martinez-Tello, F , Tiltman, A., Torhorst, J, Grigolato, P., Bettelheim, R., Neville, A. M., Burki, K., Castiglione, M., Collins, J., Lindtner, J , and Senn, H-J. Prognostic importance of c-erbB-2 expression in breast cancer. J. Clin. Oncol., 10: 1049-1056, 1992.
59. Keith, W. N., Douglas, F , Wishart, G. C., McCallum, H M., George, W. D., Kaye, S. B., and Brown, R Co-amplification of erbB2, topoisomerase IIα and retinoic acid receptor α genes in breast cancer and allelic loss at topoisomerase I on chromosome 20 Eur. J Cancer, 29A: 1469-1475, 1993