Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity

Journal of Biological Chemistry

Volumn 271, Issue 6, 1996, Pages 3163-3171

  Borgnia, Mario J ^a   Eytan, Gera D ^a   Assaraf, Yehuda G ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; COLCHICINE; CYTOTOXIC AGENT; DOLASTATIN 10; DOXORUBICIN; DRUG CARRIER; EMETINE; GLYCOPROTEIN P; GRAMICIDIN D; METHOTREXATE; METODICLOROFEN; PACLITAXEL; PEPTIDE; PROGESTERONE; QUINIDINE; QUININE; TRIMETREXATE GLUCURONATE; VALINOMYCIN; VERAPAMIL; VINBLASTINE SULFATE;

ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME INHIBITION; MICHAELIS CONSTANT; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEOLIPOSOME;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CHO CELLS; CLONE CELLS; COMPUTER SIMULATION; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; EMETINE; GRAMICIDIN; IONOPHORES; KINETICS; MATHEMATICS; MODELS, THEORETICAL; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; OLIGOPEPTIDES; P-GLYCOPROTEIN; VALINOMYCIN;

EID: 0030062653     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.6.3163     Document Type: Article

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