Herpetic eye disease: Immunopathogenesis and therapeutic measures

Expert Reviews in Molecular Medicine

Volumn 6, Issue 8, 2004, Pages

  Deshpande, Shilpa ^a   Banerjee, Kaustuv ^b   Biswas, Partha Sarathi ^b   Rouse, Barry T ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Angiogenesis; Chemokines; Cytokines; Eye; Herpetic stromal keratitis; Immunopathology; Inflammation; Polymorphonuclear leucocytes; T lymphocytes

Indexed keywords

ACICLOVIR; ANGIOGENESIS INHIBITOR; ANTIVIRUS AGENT; CHEMOKINE RECEPTOR CCR5; CIDOFOVIR; CORTICOSTEROID; ENDOTHELIAL MONOCYTE ACTIVATING POLYPEPTIDE II; FOSCARNET; GAMMA INTERFERON; GANCICLOVIR; GELATINASE B; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; PENCICLOVIR; PROTEINASE INHIBITOR; SMALL INTERFERING RNA; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VASCULOTROPIN; VERY LATE ACTIVATION ANTIGEN 4; VIRUS ANTIGEN;

ANTIVIRAL ACTIVITY; AUTOIMMUNITY; BLINDNESS; CLINICAL TRIAL; CORNEA NEOVASCULARIZATION; CORNEA TRANSPLANTATION; DISEASE SEVERITY; DRUG EFFICACY; HERPES SIMPLEX KERATITIS; HUMAN; IMMUNE COMPLEX DEPOSITION; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; IMMUNOPATHOGENESIS; INCIDENCE; INFECTION PREVENTION; INFLAMMATORY INFILTRATE; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; VARICELLA ZOSTER VIRUS; VIRUS IMMUNITY; VIRUS REPLICATION; ANIMAL; CORNEA DISEASE; DISEASE MODEL; HERPES SIMPLEX VIRUS; IMMUNOLOGY; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; T LYMPHOCYTE;

HERPES; HUMAN HERPESVIRUS 3; MURINAE; SIMPLEXVIRUS;

ANIMALS; CORNEAL DISEASES; CORNEAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; HUMANS; KERATITIS, HERPETIC; MICE; SIMPLEXVIRUS; T-LYMPHOCYTES;

EID: 10344232364     PISSN: 14623994     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1462399404007604     Document Type: Review

References (93)

1. Stein-Streilein, J. and Streilein, J.W. (2002) Anterior chamber associated immune deviation (ACAID): regulation, biological relevance, and implications for therapy. Int Rev Immunol 21, 123-152,
2. Pepose, J.S. et al. (1996) Herpes simplex virus diseases: Anterior segment of the eye. In Ocular Infection and Immunity (Pepose, J.S., Holland, G.N. and Wilhelmus, K.R., eds), pp. 905-932, Mosby, St Louis
3. Kaufman, H.E. (2002) Can we prevent recurrences of herpes infections without antiviral drugs? The Weisenfeld Lecture. Invest Ophthalmol Vis Sci 43, 1325-1329,
4. Lachmann, R. (2003) Herpes simplex virus latency. Expert Rev. Mol. Med. 5, DOI:10.1017/S1462399403006975
5. Streilein, J.W, Dana, M.R. and Ksander, B.R. (1997) Immunity causing blindness: five different paths to herpes stromal keratitis. Immunol Today 18, 443-449,
6. Remeijer, L. et al. (1997) Newly acquired herpes simplex virus keratitis after penetrating keratoplasty. Ophthalmology 104, 648-652,
7. Pepose, J.S. et al. (2003) Ocular complications of smallpox vaccination. Am J Ophthalmol 136, 343-352,
8. Kobayashi, S., Shogi, S. and Ishizu, M. (1972) Electron microscopic demonstration of virus particles in keratitis. Jpn J Ophthalmol 16, 247-250
9. Metcalf, J.F. and Kaufman, H.E. (1976) Herpetic stromal keratitis-evidence for cell-mediated immunopathogenesis. Am J Ophthalmol 82, 827-834,
10. Liesegang, T.J. (1999) Classification of herpess simplex virus keratitis and anterior uveitis. Cornea 18, 127-143,
11. Pepose, J.S. et al. (1985) Composition of cellular infiltrates in rejected human corneal allografts. Graefes Arch Clin Exp Ophthalmol 222, 128-133,
12. Youinou, P., Colin, J. and Mottier, D. (1985) Immunological analysis of the cornea in herpetic stromal keratitis. J Clin Lab Immunol 17, 105-106,
13. Youinou, P., Colin, J. and Ferec, C. (1986) Monoclonal antibody analysis of blood and cornea T lymphocyte subpopulations in herpes simplex keratitis. Graefes Arch Clin Exp Ophthalmol 224, 131-133,
14. Miller, J.K. et al. (1993) Corneal Langerhans cell dynamics after herpes simplex virus reactivation. Invest Ophthalmol Vis Sci 34, 2282-2290,
15. Verjans, G.M. et al. (1998) Identification and characterization of herpes simplex virus-specific CD4+ T cells in corneas of herpetic stromal keratitis patients. J Infect Dis 177, 484-488,
16. Koelle, D.M. et al. (2000) Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans. J Virol 74, 10930-10938,
17. Meyers-Elliott, R.H., Pettit, T.H. and Maxwell, W.A. (1980) Viral antigens in the immune ring of Herpes simplex stromal keratitis. Arch Ophthalmol 98, 897-904,
18. Pepose, J.S. et al. (1985) Detection of HLA class I and II antigens in rejected human corneal allografts. Ophthalmology 92, 1480-1484,
19. Meyers-Elliott, R.H., Chitjian, P.A. and Dethlefs, B.A. (1983) Experimental herpesvirus keratitis in the rabbit: topical versus intrastromal infection routes. Ophthalmic Res 15, 240-256,
20. Shimeld, C. et al. (1989) An improved model of recurrent herpetic eye disease in mice. Curr Eye Res 8, 1193-1205,
21. Norose, K. et al. (2002) Mapping of genes involved in murine herpes simplex virus keratitis: identification of genes and their modifiers. J Virol 76, 3502-3510,
22. Banerjee, K. et al. (2004) CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization. J Immunol. 172, 1237-1245,
23. Biswas, P.S. et al. (2004) Mice transgenic for IL-1 receptor antagonist protein are resistant to herpetic stromal keratitis: possible role of IL-1 in herpetic stromal keratitis pathogenesis. J Immunol 172, 3736-3744,
24. Carr, D.J. et al. (2003) Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection. J Virol 77, 10037-10046,
25. Chang, E. et al. (2000) Pathogenesis of herpes simplex virus type 1-induced corneal inflammation in perforin-deficient mice. J Virol 74, 11832-11840,
26. Thomas, J., Kanangat, S. and Rouse, B.T. (1998) Herpes simplex virus replication-induced expression of chemokines and proinflammatory cytokines in the eye: implications in herpetic stromal keratitis. J Interferon Cytokine Res 18, 681-690,
27. Thomas, J. et al. (1997) On the essential involvement of neutrophils in the immunopathologic disease: herpetic stromal keratitis. J Immunol 158, 1383-1391,
28. Tumpey, T.M. et al. (1996) Neutrophil-mediated. suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea. J Virol 70, 898-904,
29. Daheshia, M., Kanangat, S. and Rouse, B.T. (1998) Production of key molecules by ocular neutrophils early after herpetic infection of the cornea. Exp Eye Res 67,619-624,
30. Lee, S. et al. (2002) Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus. J Clin Invest 110, 1105-1111,
31. Jager, M.J. et al. (1991) Herpetic stromal keratitis in mice: less reversibility in the presence of Langerhans cells in the central cornea. Curr Eye Res 10 Suppl, 69-73,
32. Bauer, D. et al. (2000) Macrophage-depletion influences the course of murine HSV-1 keratitis. Curr Eye Res 20, 45-53,
33. Bauer, D. et al. (2001) Incidence and severity of herpetic stromal keratitis: impaired by the depletion of lymph node macrophages. Exp Eye Res 72, 261-269,
34. Cheng, H. et al. (2000) Role of macrophages in restricting herpes simplex virus type 1 growth after ocular infection. Invest Ophthalmol Vis Sci 41, 1402-1409,
35. Tamesis, R.R. et al. (1994) The role of natural killer cells in the development of herpes simplex virus type 1 induced stromal keratitis in mice. Eye 8 (Pt 3), 298-306,
36. Rager-Zisman, B. et al. (1987) Role of NK cells in protection of mice against herpes simplex virus-1 infection. J. Immunol 138, 884-888,
37. Bouley, D.M., Kanagat, S. and Rouse, B.T. (1996) The role of the innate immune system in the reconstituted SCID mouse model of herpetic stromal keratitis. Clin Immunol Immunopathol 80, 20-30,
38. Sciammas, R. et al. (1997) T cell receptorgamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J Exp Med 185, 1969-1975,
39. Su, Y.H. et al. (1996) Protective antibody therapy is associated with reduced chemokine transcripts in herpes simplex virus type 1 corneal infection. J Virol 70, 1277-1281,
40. Staats, H.F. and Lausch, R.N. (1993) Cytokine expression in vivo during murine herpetic stromal keratitis. Effect of protective antibody therapy. J Immunol 151, 277-283,
41. Fenton, R.R. et al. (2002) Linkage of IL-6 with neutrophil chemoattracttant expression in virus-induced ocular inflammation. Invest Ophthalmol Vis Sci 43, 737-743,
42. Yan, X.T. et al. (1998) Role of MIP-2 in neutrophil migration and tissue injury in the herpes simplex virus-1-infected cornea. Invest Ophthalmol Vis Sci 39, 1854-1862,
43. He, J. et al. (1999) Kinetics of cytokine production in the cornea and trigeminal ganglion of C57BL/6 mice after corneal HSV-1 infection. J Interferon Cytokine Res 19, 609-615,
44. Zheng, M. et al. (2001) Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis. J Virol 75, 9828-9835,
45. Kanangat, S. et al. (1996) HSV-1 mediated modulation of cytokine gene expression in a permissive cell line: selective upregulation of IL-6 gene exression. Virology 219, 295-300.
46. Tran, M.T. et al. (1998) Membrances of herpes simplex virus type-1 infected human corneal epithelial cells are not permeabilized to macromolecules and therefore do not release IL-1alpha. Virology 244, 74-78,
47. Kwong, A.D. and Frenkel, N. (1998) The herpes simplex virus virion host shutoff function. J Virol 63, 4834-4839,
48. Kumaraguru, U. and Rouse B.T. (2002) The IL-12 response to herpes simplex virus is mainly a paracrine response of reactive inflammatory cells. J Leukoc Biol 72, 564-570,
49. Zheng, M. et al. (2001) Control of stromal keratitis by inhibition of neovascularization. Am J Pathol 159, 1021-1029,
50. Zheng, M. et al. (2002) DNA containing CpG motifs induces angiogenesis. Proc Natl Acad Sci U S A 99, 8944-8949,
51. Metcalf, J.F., Hamilton, D.S. and Reichert, R.W. (1979) Herpetic keratitis in athymic (nude) mice. Infect Immun 26, 1164-1171,
52. Russell, R.G. et al. (1984) Role of T-lymphocytes in the pathogenesis of herpetic stromal keratitis. Invest Ophthalmol Vis Sci 25, 938-944,
53. Zhang, X. et al. (2002) Phenotypes of T cells infiltrating the eyes in autoimmune anterior uveitis associated with EAE. Invest Ophthalmol Vis Sci 43, 1499-1508,
54. Tumpey, T.M. et al. (1998) Absence of macrophage inflammatory protein-1alpha prevents the development of blinding herpes stromal keratitis. J Virol 72, 3705-3710,
55. Seo, S.K. et al. (2003) Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. J Immunol 171, 576-583,
56. Tang, Q. and Hendricks, R.L. (1996) Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas. J Exp Med 184, 1435-1447,
57. Daheshia, M. et al. (1998) Immune induction and modulation by topical ocular administration of plasmid DNA encoding antigens and cytokines. Vaccine 16, 1103-1110,
58. Mercadal, C.M. et al. (1993) Herpetic stromal keratitis in the reconstituted scid mouse model. J Virol 67, 3404-3408,
59. Gangappa, S., Deshpande, S.P. and Rouse, B.T. (1999) Bystander activation of CD4(+) T cells can represent an exclusive means of immunopathology in a virus infection. Eur J Immunol 29, 3674-3682,
60. Babu, J.S. et al. (1996) Viral replication is required for induction of ocular immunopathology by herpes simplex virus. J Virol 70, 101-107,
61. Zhao, Z.S. et al. (1998) Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after infection. Science 279, 1344-1347,
62. Deshpande, ST. et al. (2002) Mechanisms of pathogenesis in herpetic immunoinflammatory ocular lesions. Vet Microbiol 86, 17-26,
63. Lundberg, P et al. (2003) Herpes simplex virus type 1 DNA is immunostimulatory in vitro and in vivo. J Virol 77, 11158-11169,
64. Panoutsakopoulou, V. et al. (2001) Analysis of the relationship between viral infection and autoimmune disease. Immunity 15, 137-147,
65. Deshpande, S.P. et al. (2001) Herpes simplex virus-induced keratitis: evaluation of the role of molecular mimicry in lesion pathogenesis. J Virol 75, 3077-3088,
66. Gangappa, S. et al. (1998) Virus-induced immunoinflammatory lesions in the absence of viral antigen recognition. J Immunol 161, 4289-4300,
67. Deshpande, S. et al. (2001) Bystander activation involving T lymphocytes in herpetic stromal keratitis. J Immunol 167, 2902-2910,
68. Banerjee, K. et al. (2002) Herpetic stromal keratitis in the absence of viral antigen recognition. Cell Immunol 219, 108-118,
69. Whitley, R.J. and Roizman, B. (2001) Herpes simplex virus infections. Lancet 357, 1513-1518,
70. Bernstein, D.I. and Stanberry, L.R. (1999) Herpes simplex virus vaccines. Vaccine 17, 1681-1689,
71. Deshpande, S.P. et al. (2000) Pathogenesis of herpes simplex virus-induced ocular immunoinflammatory lesions in B-cell-deficient mice. J Virol 74, 3517-3524,
72. Deshpande, S.P. et al. (2000) Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group. Arch Ophthalmol 118, 1030-1036,
73. Chen, Y. et al. (2000) Resistant herpes simplex virus type 1 infection: an emerging concern after allogeneic stem cell transplantation. Clin Infect Dis 31, 927-935,
74. Kleymann, G. (2003) Novel agents and strategies to treat herpes simplex virus infections. Expert Opin Investig Drugs 12, 165-183,
75. Naesens, L. and De Clercq, E. (2001) Recent developments in herpesvirus therapy. Herpes 8, 12-16,
76. Mikloska, Z. et al. (2000) Monophosphoryl lipid A and QS21 increase CD8 T lymphocyte cytotoxicity to herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 production. J Immunol 164, 5167-5176,
77. Kleymann, G. et al. (2002) New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. Nat Med 8, 392-398,
78. Crute, J.J. et al. (2002) Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease. Nat Med 8, 386-391,
79. Tang, Q., Chen, W. and Hendricks, R.L. (1997) Proinflammatory functions of IL-2 in herpes simplex virus corneal infection. J Immunol 158, 1275-1283,
80. Yamada, J. et al. (2003) Local suppression of IL-1 by receptor antagonist in the rat model of corneal alkali injury. Exp Eye Res 76, 161-167,
81. Yamada, J. et al. (2000) Interleukin-1 receptor antagonist therapy and induction of anterior chamber-associated immune deviation-type tolerance after corneal transplantation. Invest Ophthalmol Vis Sci 41, 4203-4208,
82. Lee, S. et al. (2002) IL-12 suppresses the expression of ocular immunoinflammatory lesions by effects on angiogenesis. J Leukoc Biol 71, 469-476,
83. Chen, H. and Hendricks, R.L. (1998) B7 costimulatory requirements of T cells at an inflammatory site. J Immunol 160, 5045-5052,
84. Gangappa, S., Manickan, E. and Rouse, B.T. (1998) Control of herpetic stromal keratitis using CTLA4Ig fusion protein. Clin Immunol Immunopathol 86, 88-94,
85. Liuzzi, M. et al. (1994) A potent peptidomimetic inhibitor of HSV ribonucleotide reductase with antiviral activity in vivo. Nature 372, 695-698,
86. Moss, N. et al. (1995) Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase: a new class of antiviral agents. J Med Chem 38, 3617-3623,
87. Martin, J.A. et al. (1998) The design, synthesis, and properties of highly potent and selective inhibitors of herpes simplex virus types 1 and 2 thymidine kinase. Antivir Chem Chemother 9, 1-8,
88. Sun, H. et al. (1999) Molecular modeling and synthesis of inhibitors of herpes simplex virus type 1 uracil-DNA glycosylase. J Med Chem 42, 2344-2350,
89. Waxman, L. and Darke, P.L. (2000) The herpesvirus proteases as targets for antiviral chemotherapy Antivir Chem Chemother 11, 1-22,
90. Oien, N.L. et al. (2002) Broad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of herpesvirus polymerase inhibitors. Antimicrob Agents Chemother 46, 724-730,
91. Brideau, R.J. et al. (2002) Broad-spectrum antiviral activity of PNU-183792, a 4-oxodihydroquinoline, against human and animal herpesviruses. Antiviral Res 54, 19-28,
92. Kurokawa, M. et al. (2001) Biological characterization of eugeniin as an anti-herpes simplex virus type 1 compound in vitro and in vivo. J Pharmacol Exp Ther 297, 372-379,
93. Suvas, S. et al. (2004) CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol 172, 423-4132