Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans

Journal of Virology

Volumn 74, Issue 23, 2000, Pages 10930-10938

  Koelle, D M ^a   Reymond, S N ^a   Chen, H ^a   Kwok, W W ^a   McClurkan, C ^a   Gyaltsong, T ^a   Petersdorf, E W ^a   Rotkis, W ^a   Talley, A R ^a   Harrison, D A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; GAMMA INTERFERON; HLA ANTIGEN; INTERLEUKIN 5; VIRUS DNA; VIRUS PROTEIN;

ADULT; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORNEA; DNA DETERMINATION; FEMALE; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; MALE; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCID MOUSE; T LYMPHOCYTE;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CORNEA; CYTOKINES; GENES, MHC CLASS II; HERPESVIRUS 1, HUMAN; HUMANS; KERATITIS, HERPETIC; LYMPHOCYTE ACTIVATION;

EID: 0034469402     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.23.10930-10938.2000     Document Type: Article

References (72)

1. Frequencies of memory T cells specific for varicella-zoster virus, herpes simplex virus and cytomegalovirus determined by intracellular detection of cytokine expression
2. Comparison of Western blot (immunoblot) and glycoprotein G-specific immunoblot for detecting antibodies to herpes simplex types 1 and 2 in human sera
3. Resistance to herpes stromal keratitis conferred by an IgG2a-derived peptide
4. In vivo migration and function of transferred HIV-1-specific cytotoxic T cells
5. New aspects of HLA serology and biochemistry defined using monoclonal antibodies
6. Ex vivo model of leukocyte migration into herpes simplex virus-infected mouse corneas
7. Enumeration of viral antigen-reactive helper T lymphocytes in human peripheral blood by limiting dilution for analysis of viral antigen-reactive T-cell pools in virus-positive and virus-negative individuals
8. Infections with herpes simplex viruses
9. Genital herpes
10. Detection of herpes viral genomes in normal and disease corneal epithelium
11. Suppression of ongoing ocular inflammatory disease by topical administration of plasmid encoding IL-10
12. Intercellular delivery of the thymidine kinase prodrug activating enzyme by the herpes simplex virus protein VP22
13. The genome sequence of herpes simplex virus type 2
14. Herpetic stromal keratitis: An immunopathologic disease mediated by CD4+ T lymphocytes
15. Intercellular trafficking and protein delivery by a herpesvirus structural protein
16. Presence or absence of TGF-beta determines IL-4-induced generation of type 1 or type 2 CD8 T cell subsets
17. Bystander activation of CD4 T cells can represent an exclusive means of immunopathology in a virus infection
18. CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance
19. Treatment of HSV-1 stromal keratitis with topical cyclosporin A: A pilot study
20. Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease
21. Immunopathogenesis of viral ocular infections
22. IFN-γ and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice
23. A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis
24. Acyclovir for the prevention of recurrent herpes simplex virus eye disease
25. Classification of herpes simplex keratitis
26. The effect of human T cell leukemia type I infection on a herpes simplex virus-specific CD8+ cytotoxic T cell clone
27. Exacerbation of murine herpes simplex virus-mediated keratitis by Th2 type T cells
28. Evidence for herpes simplex virus latency in the human cornea
29. Direct recovery of HSV-specific T lymphocyte clones from human recurrent HSV-2 lesions
30. Antigenic specificity of human CD4+ T cell clones recovered from recurrent genital HSV-2 lesions
31. Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions
32. Preferential presentation of herpes simplex virus T-cell antigen by HLA DQA1*0501/DQB1*0201 in comparison to HLA DQA1*0201/ DQB1*0201
33. Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes
34. 4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5; comparison with responses to tegument and envelope glycoproteins
35. Herpes simplex keratitis
36. Overexpression of the herpes simplex virus type 1 tegument protein VP22 increases its incorporation into virus particles
37. Epidemiology of ocular herpes simplex. Natural history in Rochester, MN 1950 through 1982
38. Classification of herpes simplex virus keratitis and anterior uveitis
39. Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells
40. Control of protein synthesis in herpesvirus-infected cells: Analysis of the polypeptides induced by wild type and sixteen temperature sensitive mutants of HSV strain 17
41. The complete DNA sequence of the long unique region of herpes simplex virus type 1
42. Herpes simplex virus type 1 glycoproteins gB, gC, and gD are major targets for CD4 T-lymphocyte cytotoxicity in HLA-DR expressing human epidermal keratinocytes
43. Herpes simplex virus protein targets for CD4 and CD8 lymphocyte cytotoxicity in cultured epidermal keratinocytes treated with interferon-γ
44. In vivo production of cytokines and beta (C-C) chemokines in human recurrent herpes simplex lesions - Do herpes simplex virus-infected keratinocytes contribute to their production?
45. Anterior chamber-associated immune deviation
46. Phenotypic and functional studies on ocular T cells during herpetic infections of the eye
47. Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis
48. Typing of clinical HSV isolates using mouse monoclonal antibodies to HSV-1 and HSV-2: Comparison with type-specific rabbit antisera and restriction endonuclease analysis of viral DNA
49. High frequency of CD8+ cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes
50. Severe genital herpes infections in HIV-infected individuals with impaired HSV-specific CD8+ cytotoxic T lymphocyte responses
51. CD8 T cell clones inhibit antitumor T cell function by secreting IL-10
52. Sequenase sequence profiles used for HLA-DPB1 sequence-based typing
53. Development of a high-throughput quantitative assay for detecting HSV DNA in clinical samples
54. The human MHC-restricted cellular response to herpes simplex virus type 1 is mediated by CD4, CD8 T cells and is restricted to the DR region of the MHC complex
55. Characterization of T cell responses to herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) using a TNF-beta ELISpot cytokine assay
56. Prospects for control of herpes simplex virus disease through immunization
57. Immunity causing blindness: Five different paths to herpes stromal keratitis
58. Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas
59. Clinical and immunohistochemical correlation of herpetic keratitis with the expression of HLA-DR antigen
60. Limiting dilution assays for the determination of immunocompetent cell frequencies I. Data analysis
61. Ocular immunosuppressive microenvironment
62. On the essential involvement of neutrophils in the immunopathologic disease: Herpetic stromal keratitis
63. Absence of macrophage inflammatory protein-1 alpha prevents the development of blinding herpes stromal keratitis
64. Herpes simplex virus specific T-cells infiltrate the cornea of patients with herpes stromal keratitis: No evidence for intra-corneal autoreactive T-cells in human HSK
65. Identification and characterization of herpes simplex virus-specific CD4+ T cells in corneas of herpetic stromal keratitis patients
66. Identification of an MHC class I-restricted autoantigen in type I diabetes by screening an organ-specific cDNA library
67. Fas-independent cytotoxicity mediated by CD4+ CTL directed against herpes simplex virus-infected cells
68. Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. I. Lysis restricted by HLA Class II MB and DR antigens
69. Monoclonal antibody analysis of blood and cornea T lymphocyte subpopulations in herpes simplex keratitis
70. Immunologic analysis of the cornea in herpetic stromal keratitis
71. Molecular mimicry by herpes simplex virus-type 1: Autoimmune disease after viral infection