Identification and characterization of herpes simplex virus-specific CD4+ T cells in corneas of herpetic stromal keratitis patients

Journal of Infectious Diseases

Volumn 177, Issue 2, 1998, Pages 484-488

  Verjans, Georges M G R ^a   Remeijer, Lies ^b   Van Binnendijk, Robert S ^b   Cornelissen, José G C ^b   Völker Dieben, Hennie J ^b   Baarsma, Seerp G ^b   Osterhaus, Albert D M E ^b  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HLA ANTIGEN CLASS 2; INTERLEUKIN 4; INTERLEUKIN 5;

ADULT; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CASE REPORT; CORNEA; HELPER CELL; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS; HUMAN; IMMUNOPATHOGENESIS; IMMUNOPHENOTYPING; MALE; MITOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0031908355     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/517382     Document Type: Article

References (16)

1. Doymaz MZ, Rouse BT. Immunopathology of herpes simplex virus infections. Cur Top Microbiol Immunol 1992;179:121-36.
2. Niemialtowski MG, Rouse BT. Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis. J Immunol 1992;149:3035-9.
3. Hendricks RL, Tumpey TM, Finnegan A. IFN-γ and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice. J Immunol 1992;149:3023-8.
4. Babu JS, Kanangat S, Rouse BT. T cell cytokine mRNA expression during the course of the immunopathologic ocular disease herpetic stromal keratitis. J Immunol 1995;154:4822-9.
5. Youinou P, Colin J, Ferec C. Monoclonal antibody analysis of blood and cornea T lymphocyte subpopulations in herpes simplex keratitis. Graefe's Arch Clin Exp Ophthalmol 1986;224:131-3.
6. Holbach LM, Font RL, Naumann GOH. Herpes simplex stromal and endothelial keratitis: granulomatous cell reactions at the level of Descemet's membrane, the stroma, and Bowman's layer. Ophthalmology 1990;97:722-8.
7. + cytotoxic T cell clones. J Immunol 1989;142:2847-54.
8. + Th1-like cells. Scand J Immunol 1993;37:43-51.
9. Verjans, GMGM, Klaren VNA, Leirisalo-Repo M, et al. Heterogeneity of rearranged T cell receptor Vα and Vβ gene transcripts in synovial fluid T cells of HLA-B27 positive reactive arthritis patients. Clin Rheumatol 1996;15:91-6.
10. van Dongen JJM, van den Beemd MWM, Schellekens M, Wolvers-Tettero ILM, Langerak AW, Groeneveld K. Analysis of malignant T cells with Vβ antibody panel. Immunologist 1996;4:37-40.
11. Mcbride BW, McGill JI, Smith JL. MHC class I and class II antigen expression in normal human corneas and in corneas from cases of herpetic keratitis. Immunol 1988;65:583-7.
12. + T cells. J Immunol 1991;146:1341-7.
13. Mikloska Z, Kesson AM, Penfold MET, Cunningham AL. Herpes simplex virus protein targets for CD4 and CD8 lymphocyte cytotoxicity in cultured epidermal keratinocytes treated with interferon-γ. J Infect Dis 1996;173:7-17.
14. Tang Q, Hendricks RL. Interferon-γ regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas. J Exp Med 1996;184:1435-47.
15. Babu JS, Thomas J, Kanangat S, Morrison LA, Knipe DM, Rouse BT. Viral replication is required for induction of ocular immunopathology by herpes simplex virus. J Virol 1996;70:101-7.
16. Avery AC, Zhao ZS, Rodriguez A, et al. Resistance to herpes stromal keratitis conferred by an IgG2a-derived peptide. Nature 1995;376:431-4.