CXCR2-/- Mice Show Enhanced Susceptibility to Herpetic Stromal Keratitis: A Role for IL-6-Induced Neovascularization

Journal of Immunology

Volumn 172, Issue 2, 2004, Pages 1237-1245

  Banerjee, Kaustuv ^a   Biswas, Partha S ^a   Kim, Bumseok ^a   Lee, Sujin ^a   Rouse, Barry T ^a,b  

^a UNIVERSITY OF TENNESSEE   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; CHEMOKINE; CHEMOKINE RECEPTOR CXCR2; INTERLEUKIN 6; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DISEASE PREDISPOSITION; EYE INFECTION; FEMALE; HERPES SIMPLEX KERATITIS; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; VIRUS INFECTION;

EID: 1542669813     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.2.1237     Document Type: Article

References (43)

1. Streilein, J. W., M. R. Dana, and B. R. Ksander. 1997. Immunity causing blindness: five different paths to herpes stromal keratitis. Immunol. Today 18:443.
2. Dana, M. R., Y. Qian, and P. Hamrah. 2000. Twenty-five-year panorama of corneal immunology: emerging concepts in the immunopathogenesis of microbial keratitis, peripheral ulcerative keratitis, and corneal transplant rejection. Cornea 19:625.
3. Thomas, J., and B. T. Rouse. 1997. Immunopathogenesis of herpetic ocular disease. Immunol. Res. 16:375.
4. Deshpande, S. P., M. Zheng, S. Lee, and B. T. Rouse. 2002. Mechanisms of pathogenesis in herpetic immunoinflammatory ocular lesions. Vet. Microbiol. 86:17.
5. + T lymphocytes. Invest. Ophthalmol. Visual Sci. 33:2165.
6. Thomas, J., S. Gangappa, S. Kanangat, and B. T. Rouse. 1997. On the essential involvement of neutrophils in the immunopathologic disease: herpatic stromal keratitis. J. Immunol. 158:1383.
7. Mercadal, C. M., D. M. Bouley, D. DeStephano, and B. T. Rouse. 1993. Herpetic stromal keratitis in the reconstituted scid mouse model. J. Virol. 67:3404.
8. Kumaraguru, U., and B. T. Rouse. 2002. The IL-12 response to herpes simplex virus is mainly a paracrine response of reactive inflammatory cells. J. Leukocyte Biol. 72:564.
9. Tumpey, T. M., S. H. Chen, J. E. Oakes, and R. N. Lausch. 1996. Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea. J. Virol. 70:898.
10. Lee, S., M. Zheng, B. Kim, and B. T. Rouse. 2002. Role of matrix metallopproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus J. Clin. Invest. 110:1105.
11. Kumaraguru, U., I. Davis, and B. T. Rouse. 1999. Chemokines and ocular pathology caused by corneal infection with herpes simplex virus. 5:42.
12. Kernacki, K. A., R. P. Barrett, J. A. Hobden, and L. D. Hazlett. 2000. Macrophage inflammatory protein-2 is a mediator of polymorphonuclear neutrophil influx in ocular bacterial infection. J. Immunol. 164:1037.
13. Yan, X. T., T. M. Tumpey, S. L. Kunkel, J. E. Oakes, and R. N. Lausch. 1998. Role of MIP-2 in neutrophil migration and tissue injury in the herpes simplex virus-1-infected cornea. Invest. Ophthalmol. Visual Sci. 39:1854.
14. Bacon, K., M. Baggiolini, H. Broxmeyer, R. Horuk, I. Lindley, A. Mantovani, K. Maysushima, P. Murphy, H. Nomiyama, J. Oppenheim, et al. 2002. Chemokine/Chemokine receptor nomenclature. J. Interferon Cytokine Res. 22:1067.
15. Cacalano, G., J. Lee, K. Kikly, A. M. Ryan, S. Pitts-Meek, B. Hultgren, W. I. Wood, and M. W. Moore. 1994. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 265:682.
16. Becker, M. D., L. M. O'Rourke, W. S. Blackman, S. R. Planck, and J. T. Rosenbaum. 2000. Reduced leukocyte migration, but normal rolling and arrest, in interleukin-8 receptor homologue knockout mice. Invest. Ophthalmol. Visual Sci. 41:1812.
17. Del Rio, L., S. Bennouna, J. Salinas, and E. Y. Denkers. 2001. CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection. J. Immunol. 167:6503.
18. Devalaraja, R. M., L. B. Nanney, J. Du, Q. Qian, Y. Yu, M. N. Devalaraja, and A. Richmond. 2000. Delayed wound healing in CXCR2 knockout mice. J. Invest. Dermatol. 115:234.
19. Godaly, G., L. Hang, B. Frendeus, and C. Svanborg, 2000. Transepithelial neutrophil migration is CXCR1 dependent in vitro and is defective in IL-8 receptor knockout mice. J. Immunol. 165:5287.
20. Goncalves, A. S., and R. Appelberg. 2002. The involvement of the chemokine receptor CXCR2 in neutrophil recruitment in LPS-induced inflammation and in Mycobacterium avium infection. Scand. J. Immunol. 55:585.
21. Hall, L. R., E. Diaconu, R. Patel, and E. Pearlman. 2001. CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness). J. Immunol. 166:4035.
22. Kielian, T., B. Barry, and W. F. Hickey. 2001. CXC chemokine receptor-2 ligands are required for neutrophil-mediated host defense in experimental brain abscesses. J. Immunol. 166:4634.
23. Spear, P. G., and B, Roizman. 1972. Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpesvirion. J. Virol. 9:143.
24. Zheng, M., S. Deshpande, S. Lee, N. Ferrara, and B. T. Rouse. 2001. Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis. J. Virol. 75:9828.
25. Stechschulte, S. U., A. M. Joussen, H. A. von Recum, V. Poulaki, Y. Moromizato, J. Yuan, R. J. D'Amato, C. Kuo, and A. P. Adamis. 2001. Rapid ocular angiogenic control via naked DNA delivery to cornea. Invest. Ophthalmol. Visual Sci. 42:1975.
26. Frendeus, B., G. Godaly, L. Hang, D. Karpman, and C. Svanborg. 2001. Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis. J. Infect. Dis. 183 (Suppl. 1):S56.
27. Deshpande, S. P., M. Zheng, M. Daheshia, and B. T. Rouse. 2000. Pathogenesis of herpes simplex virus-induced ocular immunoinflammatory lesions in B-cell-deficient mice. J. Virol. 74:3517.
28. Banerjee, K., S. Deshpande, M. Zheng, U. Kumaraguru, S. P. Schoenberger, and B. T. Rouse. 2002. Herpetic stromal keratitis in the absence of viral antigen recognition. Cell. Immunol. 219:108.
29. + T cells can represent an exclusive means of immunopathology in a virus infection. Eur. J. Immunol. 29:3674.
30. Thomas, J., S. Kanangat, and B. T. Rouse. 1998. Herpes simplex virus replication-induced expression of chemokines and proinflammatory cytokines in the eye: implications in herpetic stromal keratitis. J. Interferon Cytokine Res. 18:681.
31. Fenton, R. R., S. Molesworth-Kenyon, J. E. Oakes, and R. N. Lausch. 2002. Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation. Invest. Ophthalmol. Visual Sci. 43:737.
32. Cohen, T., D. Nahari, L. W. Cerem, G. Neufeld, and B. Z. Levi. 1996. Interleukin 6 induces the expression of vascular endothelial growth factor. J. Biol. Chem. 271:736.
33. Wei, L. H., M. L. Kuo, C. A. Chen, C. H. Chou, K. B. Lai, C. N. Lee, and C. Y. Hsieh. 2003. Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 22:1517.
34. Xue, M. L., A. Thakur, and M. Willcox. 2002. Macrophage inflammatory protein-2 and vascular endothelial growth factor regulate corneal neovascularization induced by infection with Pseudomonas aeruginosa in mice. Immunol. Cell Biol. 80:323.
35. Hurt, M., S. Apte, H. Leher, K. Howard, J. Niederkorn, and H. Alizadeh. 2001. Exacerbation of Acanthamoeba keratitis in animals treated with anti-macrophage inflammatory protein 2 or antineutrophil antibodies. Infect. Immun. 69:2988.
36. Carr, D. J., P. Harle, and B. M. Gebhardt. 2001. The immune response to ocular herpes simplex virus type 1 infection. Exp. Biol. Med. 226:353.
37. + T cells are selectively activated and retained in latently infected sensory ganglia. Immunity 18:593.
38. Ohmann, H. B., M. Campos, D. R. Fitzpatrick, N. Rapin, and L. A. Babiuk. 1989. A neutrophil-derived antiviral protein: induction requirements and biological properties. J. Virol. 63:1916.
39. Van Strijp, J. A., M. E. van der Tol, L. A. Miltenburg, K. P. van Kessel, and J. Verhoef. 1991. Tumor necrosis factor triggers granulocytes to internalize complement-coated virus particles. Immunology 73:77.
40. Zheng, M., M. A. Schwarz, S. Lee, U. Kumaraguru, and B. T. Rouse. 2001. Control of stromal keratitis by inhibition of neovascularization. Am. J. Pathol. 159:1021.
41. Tumpey, T. M., H. Cheng, D. N. Cook, O. Smithies, J. E. Oakes, and R. N. Lausch. 1998. Absence of macrophage inflammatory protein-la prevents the development of blinding herpes stromal keratitis. J. Virol. 72:3705.
42. Kanangat, S., J. S. Babu, D. M. Knipe, and B. T. Rouse. 1996. HSV-1-mediated modulation of cytokine gene expression in a permissive cell line: selective upregulation of IL-6 gene expression. Virology 219:295.
43. + T cell-mediated suppression by dendritic cells. Science 299:1033.