Metabolic activation of aromatic amine mutagens by simultaneous expression of human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and N-acetyltransferase in Escherichia coli

Chemical Research in Toxicology

Volumn 11, Issue 1, 1998, Pages 70-74

  David Josephy, P ^a   Evans, David H ^a   Parikh, Asit ^b   Peter Guengerich, F ^b  

^a UNIVERSITY OF GUELPH   (Canada)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOANTHRACENE; ACYLTRANSFERASE; AROMATIC AMINE; CYTOCHROME P450; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ANIMAL CELL; ARTICLE; ESCHERICHIA COLI; LIVER HOMOGENATE; MALE; MUTAGEN TESTING; MUTAGENESIS; NONHUMAN; PLASMID; RAT;

ARYLAMINE N-ACETYLTRANSFERASE; BIOTRANSFORMATION; CYTOCHROME P-450 CYP1A2; ESCHERICHIA COLI; HUMANS; HYDROCARBONS, AROMATIC; MUTAGENS; NADH, NADPH OXIDOREDUCTASES; NADPH-FERRIHEMOPROTEIN REDUCTASE; PLASMIDS;

ANIMALIA; ESCHERICHIA COLI; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 2642703427     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx970171q     Document Type: Article

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