Comparative Analysis of In Vitro and In Vivo Pharmacokinetic Parameters Related to Individual Variability of GTS-21 in Canine

Drug Metabolism and Pharmacokinetics

Volumn 17, Issue 1, 2002, Pages 75-82

  Komuro, Masahito ^a   Kawaguchi, Yasuro ^a   Okudaira, Kazuho ^b   Hayashi, Masahiro ^c   Kiwada, Hiroshi ^d   Azuma, Ryotaro ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

^b TOHO UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

CYP1A; dog; GTS 21; hepatic availability; individual variability; intrinsic clearance

Indexed keywords

EID: 0842344073     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.17.75     Document Type: Article

References (26)

1. Danckwerts, M. P., van der Watt, J. G. and Moodley, I.: Pharmacokinetic evaluation in dogs of theophylline in a novel zero-order release core-in-cup tablet. Biopharm. Drug Dispos., 19: 517-522 (1998).
2. Khaled, K. A., Asiri, Y. A. and El-Sayed, Y. M.: In vivo evaluation of hydrochlorothiazide liquisolid tablets in beagle dogs. Int. J. Pharm., 222: 1-6 (2001).
3. Paulson, S. K., Engel, L., Reitz, B., Bolten, S., Burton, E. G., Maziasz, T. J., Yan, B. and Schoenhard, G. L.: Evidence for polymorphism in the canine metabolism of the cyclooxygenase 2 inhibitor, celecoxib. Drug Metab. Dispos., 27: 1133-1142 (1999).
4. Kem, W. R.: The brain a7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21). Behav. Brain Res., 113: 169-181 (2000).
5. Adams, C. E., Stevens, K. E., Kem, W. R. and Freed-man, R.: Inhibition of nitric oxide synthase prevents a7 nicotinic receptor-mediated restoration of inhibitory auditory gating in rat hippocampus. Brain Res., 877: 235-244 (2000).
6. Azuma, R., Hirota, T., Manabe, H., Komuro, M. and Kiwada, H.: First-pass of GTS-21 on canine gut wall and liver determined by portal-systemic concentration difference. Eur. J. Pharm. Sci., 14: 159-165 (2001).
7. Azuma, R., Komuro, M., Korsch, B. H., Andre, J. C., Onnagawa, O., Black, S. R. and Mathews, J. M.: Metabolism and disposition of GTS-21, a novel drug for Alzheimer's disease. Xenobiotica, 29: 747-762 (1999).
8. Iwatsubo, T., Hirota, N., Ooie, T., Suzuki, H., Shimada, N., Chiba, K., Ishizaki, T., Green, C. E., Tyson, C. A. and Sugiyama, Y.: Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data. Pharmacol. Ther., 73: 147-171 (1997).
9. Azuma, R., Minami, Y. and Satoh, T.: Simultaneous determination of GTS-21 and its metabolite in rat plasma by high-performance liquid chromatography using solidphase extraction. J. Chromatogr. B, 686: 229-234 (1996).
10. Nelson, A. C., Huang, W. and Moody, D. E.: Variables in human liver microsome preparation: impact on the kinetics of 1-a-acetylmethadol (LAAM) N-demethyla-tion and dextromethorphan O-demethylation. Drug Metab. Dispos., 29: 319-325 (2001).
11. Sawada, Y.: Physiological pharmacokinetics. In Hanano, M., umemura, K. and Iga T. (eds.): Applied Pharmacokinetics-Theory and Experiments. Soft Science, Tokyo, 1985, pp. 477.
12. Yamaoka, K., Tanigawara, Y., Nakagawa, T. and uno, T.: A pharmacokinetic analysis program (MuLTI) for microcompute. J. Pharmacobiodyn., 4: 879-885 (1981).
13. Omura, T. and Sato, R.: The carbon monoxide-binding pigment of liver microsomes: I. Evidence for its hemoprotein nature. J. Biol. Chem., 239: 2370-2378 (1964).
14. Eguchi, K., Nishibe, Y., Baba, T. and Ohno, K.: Quantitation of cytochrome P450 enzymes (CYP1A1 / 2, 2B11, 2C21 and 3A12) in dog liver microsomes by enzyme-linked immunosorbent assay. Xenobiotica, 26: 755-763 (1996).
15. Iwatsubo, T., Hirota, N., Ooie, T., Suzuki, H. and Sugiyama, Y.: Prediction of in vivo drug disposition from in vitro data based on physiological Pharmacokinetics. Biopharm. Drug Dispos., 17: 273-310 (1996).
16. Chauret, N., Gauthier, A., Martin, J. and Nicoll-Griffith, D. A.: In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse. Drug Metab. Dispos., 25: 1130-1136 (1997).
17. Shimada, T., Mimura, M., Inoue, K., Nakamura, S., Oda, H., Ohmori, S. and Yamazaki, H.: Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans. Arch. Toxicol., 71: 401-408 (1997).
18. Bogaards, J. J., Bertrand, M., Jackson, P., Oudshoorn, M. J., Weaver, R. J., van Bladeren, P. J. and Walther, B.: Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica, 30: 1131-1152 (2000).
19. Pearce, R., Greenway, D. and Parkinson, A.: Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation. Arch. Biochem. Biophys., 298: 211-225 (1992).
20. Sharer, J. E., Shipley, L. A., Vandenbranden, M. R., Binkley, S. N. and Wrighton, S. A.: Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey. Drug Metab. Dispos., 23: 1231-1241 (1995).
21. Roussel, F., Duignan, D. B., Lawton, M. P., Obach, R. S., Strick, C. A. and Tweedie, D. J.: Expression and characterization of canine cytochrome P450 2D15. Arch. Biochem. Biophys., 357: 27-36 (1998).
22. Tasaki, T., Nakamura, A., Itoh, S., Ohashi, K., Yamamoto, Y., Masuda, M., Iwata, H., Kazusaka, A., Kamataki, T. and Fujita, S.: Expression and characterization of dog CYP2D15 using baculovirus expression system. J. Biochem. (Tokyo), 123: 162-168 (1998).
23. Adas, F., Berthou, F., Salaun, J. P., Dreano, Y. and Amet, Y.: Interspecies variations in fatty acid hydroxylations involving cytochromes P450 2E1 and 4A. Toxicol. Lett., 110: 43-55 (1999).
24. Smith, B. J., Zupan, L. A., Hu, J. K., Diters, R. W., Gibson, G. W. and Norton, J. N.: Characterization of the effects of tebufelone on hepatic cytochrome P450 in the beagle dog. Drug Metab. Dispos., 24: 523-528 (1996).
25. Zhao, X. J. and Ishizaki, T.: The in vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes. J. Pharmacol. Exp. Ther., 283: 1168-1176 (1997).
26. Fraser, D. J., Feyereisen, R., Harlow, G. R. and Halpert, J. R.: Isolation, heterologous expression and functional characterization of a novel cytochrome P450 3A enzyme from a canine liver cDNA library. J. Pharmacol. Exp. Ther., 283: 1425-1432 (1997).