In vivo evaluation of hydrochlorothiazide liquisolid tablets in beagle dogs

International Journal of Pharmaceutics

Volumn 222, Issue 1, 2001, Pages 1-6

  Khaled, Khaled A ^a,b   Asiri, Yousif A ^a   El Sayed, Yousry M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Assiut University   (Egypt)

Author keywords

Bioavailability; Hydrochlorothiazide; Liquisolid tablets; Pharmacokinetic

Indexed keywords

HYDROCHLOROTHIAZIDE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; IN VIVO STUDY; MALE; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; STATISTICAL ANALYSIS; TABLET FORMULATION;

ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMALS; ANTIHYPERTENSIVE AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DIURETICS; DOGS; HALF-LIFE; HYDROCHLOROTHIAZIDE; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; MALE; METABOLIC CLEARANCE RATE; SODIUM CHLORIDE SYMPORTER INHIBITORS; TABLETS;

EID: 0035800242     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00633-0     Document Type: Article

References (10)

1. High-pressure liquid chromatographic determination of chlorothiazide and hydrochlorothiazide in plasma and urine: Preliminary results of clinical studies
2. Formulation and evaluation of hydrochlorothiazide liquisolid tablets
3. Dissolution rates of corticoid solutions dispersed on silicas
4. Evaluation of different metrics as indirect measures of rate of drug absorption from extended release dosage forms at steady state
5. Effect of elevated viscosity in the upper gastrointestinal tract on drug absorption in dogs
6. Correlation of urinary excretion with in vitro dissolution using several dissolution methods for hydrochlorothiazide formulations
7. The absolute oral bioavailability of selected drugs
8. Powdered solution technology: Principles and mechanisms
9. Bioavailability improvement of clofibrate using liquisolid compact technology