First-pass of GTS-21 on canine gut wall and liver determined by portal-systemic concentration difference

European Journal of Pharmaceutical Sciences

Volumn 14, Issue 2, 2001, Pages 159-165

  Azuma, Ryotaro ^a   Hirota, Tomio ^a   Manabe, Hiroshi ^a   Komuro, Masahito ^a   Kiwada, Hiroshi ^b  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Bioavailability; First pass effect; GTS 21; Individual variability; Portal venous blood flow

Indexed keywords

ABSORPTION; BIOLOGICAL ORGANS; BLOOD;

CANINE GUT WALLS;

DIAGNOSIS;

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; FEMORAL VEIN; FIRST PASS EFFECT; INTESTINE WALL; LIVER; MALE; NONHUMAN; PORTAL VEIN BLOOD; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; VARIANCE;

ANIMALS; BENZYLIDENE COMPOUNDS; BIOLOGICAL AVAILABILITY; DOGS; INTESTINAL ABSORPTION; INTESTINE, SMALL; LIVER; MALE; NICOTINIC AGONISTS; PORTAL SYSTEM; PYRIDINES;

EID: 0034898384     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(01)00166-X     Document Type: Article

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