Lung infections and aging

Ageing Research Reviews

Volumn 3, Issue 1, 2004, Pages 55-67

  Meyer, Keith C ^a  

^a University of Wisconsin Health   (United States)

Author keywords

Chronic obstructive pulmonary disease; Pneumonia; Respiratory infection

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL VACCINE; BETA LACTAM ANTIBIOTIC; CEPHALOSPORIN; COTRIMOXAZOLE; DOXYCYCLINE; KETOLIDE; LINEZOLID; MACROLIDE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE; VANCOMYCIN;

AGED; AGING; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE PREDISPOSITION; DISEASE SEVERITY; HIGH RISK POPULATION; HOST RESISTANCE; HUMAN; INFECTION RESISTANCE; LUNG INFECTION; PNEUMONIA; RESPIRATORY TRACT INFECTION; REVIEW; RISK FACTOR; TREATMENT OUTCOME;

EID: 0842281437     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arr.2003.07.002     Document Type: Review

References (79)

1. American Thoracic Society Board of Directors, 2001. Guidelines for the management of adults with community-acquired pneumonia: diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am. J. Respir. Crit. Care Med. 163, 1730-1754.
2. Antonini J.M., Roberts J.R., Clarke R.W., Yang H., Barger M.W., Ma J.Y.C., Weissman D.N. Pulmonary bacterial clearance in Fischer 344 rats after intratracheal instillation of Listeria monocytogenes. Chest. 120:2001;240-249.
3. Artz A.S., Ershler W.B., Longo D.L. Pneumococcal vaccination and revaccination of older adults. Clin. Microbiol. Rev. 16:2003;308-318.
4. Atlas R.M. Bioterrorism: from threat to reality. Annu. Rev. Microbiol. 56:2002;167-185.
5. Ayars G.H., Altman L.C., Fretwell M.D. Effect of decreased salivation and pH on the adherence of Klebsiella species to human buccal epithelial cells. Infect. Immun. 38:1982;179-182.
6. Baik I., Curhan G.C., Rimm E.B., Bendich A., Willett W.C., Fawzi W.W. A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women. Arch. Intern. Med. 160:2000;3082-3088.
7. Bartlett J.G., Mundy L.M. Current concepts: community-acquired pneumonia. N. Engl. J. Med. 333:1995;1618-1624.
8. Bonomo R.A. Resistant pathogens in respiratory tract infections in older people. J. Am. Geriatr. Soc. 50:2002;S236-S241.
9. Butler J.C., Breiman R.F., Campbell J.F., Lipman H.B., Broome C.V., Facklam R.R. Pneumococcal polysaccharide vaccine efficacy: an evaluation of current recommendations. JAMA. 270:1993;1826-1831.
10. Centers for Disease Control and Prevention, 1997. Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 46(RR-8), 1-24.
11. Chan E.D., Welsh C.H. Geriatric respiratory medicine. Chest. 114:1998;1704-1733.
12. Chouinard J. Dysphagia in Alzheimer disease: a review. J. Nutr. Health Aging. 4:2000;214-217.
13. Crosby, A.W., 1989. America's Forgotten Pandemic: The Influenza of 1918, Cambridge University Press, Cambridge, England.
14. Delves P.J., Roitt I.M. The immune system. N. Engl. J. Med. 343:2000a;37-49.
15. Delves P.J., Roitt I.M. The immune system. N. Engl. J. Med. 343:2000b;108-117.
16. Doern G.V., Pfaller M.A., Kugler K., Freeman J., Jones R.N. Prevalence of antimicrobial resistance among respiratory tract isolates of Streptococcus pneumoniae in North America: 1997 results from the SENTRY Antimicrobial Surveillance Program. Clin. Infect. Dis. 27:1998;764-770.
17. Evans W.J., Campbell W.W. Sarcopenia and age-related changes in body composition and function capacity. J. Nutr. 123:1993;465-468.
18. Fein A.M. Pneumonia in the elderly: overview of diagnostic and therapeutic approaches. Clin. Infect. Dis. 28:1999;726-729.
19. Fine M.J., Auble T., Yealy D.M., Hanusa B.H., Weissfeld L.A., Singer D.E., Coley C.M., Marrie T.J., Kapoor W.N. A prediction rule to identify low-risk patients with community-acquired pneumonia. N. Engl. J. Med. 336:1997;243-250.
20. Fischer P., Hoek G., Brunekreef B., Verhoeff A., van Wijnen J. Air pollution and mortality in the Netherlands: are the elderly more at risk? Eur. Respir. J. 21:2003;34S-38S.
21. Franceschi C., Monti D., Sansoni P., Cossarizza A. The immunology of exceptional individuals: the lesson of centenarians. Immunol. Today. 16:1995;12-16.
22. Gillissen A., Hoffken G. Early therapy with the neuraminidase inhibitor oseltamivir maximizes its efficacy in influenza treatment. Med. Microbiol. Immunol. 191:2002;165-168.
23. Gross P.A., Hermogenes A.W., Sacks H.S., Lau J., Levandowski R.A. The efficacy of influenza vaccinatnions in elderly persons: a meta-analysis and review of the literature. Ann. Int. Med. 123:1995;518-527.
24. Ho J.C., Chan K.N., Hu W.H., Lam W.K., Zheng L., Tipoe G.L., Sun J., Leung R., Tsang K.W. The effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia. Am. J. Respir. Crit. Care Med. 163:2001;983-988.
25. Houtmeyers E., Gosselink R., Gayan-Ramirez G., Decramer M. Regulation of mucociliary clearance in health and disease. European Respiratory Journal. 13:1999;1177-1188.
26. Jackola D.R., Ruger J.K., Miller R.A. Age-associated changes in human T cell phenotype and function. Aging Clin. Exp. Res. 6:1994;25-34.
27. Kikuchi R., Watabe N., Konno T., Mishina N., Sekizawa K., Sasaki H. High incidence of silent aspiration in elderly patients with community-acquired pneumonia. Am. J. Respir. Crit. Care Med. 150:1994;251-253.
28. Ksiazek T.G., Erdman D., Goldsmith C.S., Zaki C.S., Peret T., Emery S., Tong S., Urbani C., Comer J.A., Lim W., Rollin P.E., Dowell S.F., Ling A.E., Humphrey C.D., Shieh W.J., Guarner J., Paddock C.D., Rota P., Fields B., DeRisi J., Yang J.Y., Cox N., Hughes J.M., LeDuc J.W., Bellini W.J., Anderson L.J. A novel coronavirus associated with severe acute respiratory syndrome. N. Engl. J. Med. 348:2003;1953-1966.
29. Kunzli K. The public health relevance of air pollution abatement. Eur. Respir. J. 20:2002;198-209.
30. Laforce F.M., Trow R., Wang W.L. Human oral defenses against gram negative rods. Am. Rev. Respir. Dis. 114:1976;929-935.
31. Li S.P., Verma S., Miller R.A. Age-related defects in T cell expression of CD40 ligand and induction of in vitro B cell activation. Aging Immunol. Infect. Dis. 6:1995;79-93.
32. Loeb M., McGeer A., McArthur M., Walter S., Simor A.E. Risk factors for pneumonia and other lower respiratory tract infections in elderly residents of long-term care facilities. Arch. Intern. Med. 159:1999;2058-2064.
33. Loeb M., McGeer A., McArthur M., Peeling R.W., Petric M., Simor A.E. Surveillance for outbreaks of respiratory tract infections in nursing homes. C.M.A.J. 162:2000;1133-1137.
34. Lundbäck B., Gulsvik A., Albers M., Bakke P., Rönmark E., van den Boom G., Brøgger J., Larsson L., Welle I., van Weel C., Omenaas E. Epidemiological aspects and early detection of chronic obstructive airway diseases in the elderly. Eur. Respir. J. 21:2003;3S-9S.
35. Macuso P., Gottschalk A., Phare S.M., Peters-Golden M., Lukacs N.W., Huffnagle G.B. Leptin-deficient mice exhibit impaired host defense in gram-negative pneumonia. J. Immunol. 168:2002;4018-4024.
36. Maffei M., Halass J., Ravussin E., Pratlet R.E., Lee G.H., Zhang Y., Fei H., Kim S., Lallone R., Ranganathan S. Leptin levels in human and rodent: measurements of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1:1995;1155-1161.
37. Maki D.G. SARS: 1918 Revisited? The urgent need for global collaboration in public health. Mayo Clin. Proc. 78:2003;813-816.
38. Matsuse T., Oka T., Kida K., Fukuchi Y. Importance of diffuse aspiration bronchiolitis caused by chronic occult aspiration in the elderly. Chest. 110:1996;1289-1293.
39. Medzhitov R., Janeway C. Jr. Innate immunity. N. Engl. J. Med. 343:2000;338-344.
40. Meehan T.P., Fine M.J., Krumholz H. Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA. 278:1997;2080-2084.
41. Metlay J.P., Schulz R., Li Y.H., Singer D.E., Marrie T.J., Coley C.M., Hough L.J., Obrosky D.S., Kapoor W.N., Fine M.J. Influence of age on symptoms at presentation in patients with community-acquired pneumonia. Arch. Intern. Med. 157:1997;1453-1459.
42. Metlay C.G., Farley M.M., Hadler J., Harrison L.H., Lexau C., Reingold A., Lefkowitz L., Cieslak P.R., Cetron M., Zell E.R., Jorgensen J.H., Schuchat A. Impact of penicillin susceptibililty on medical outcomes for adult patients with bacteremic pneumococcal pneumonia. Clin. Infect. Dis. 30:2000;520-528.
43. Meyer K.C. The role of immunity in susceptibility to respiratory infection in the aging lung. Respir. Physiol. 128:2001;23-31.
44. Meyer, K.C., 2002. Lung immunology and host defense. In: Bittar, E.E. (Ed.), Pulmonary Biology in Health and Disease, Springer, New York.
45. Meyer K.C., Soergel P. Bronchoalveolar lymphocyte phenotypes change in the normal aging human lung. Thorax. 54:1999;697-700.
46. Meyer K.C., Ershler W., Rosenthal N., Lu X., Peterson K. Immune dysregulation in the aging human lung. Am. J. Respir. Crit. Care Med. 153:1996;1072-1079.
47. Meyer K.C., Rosenthal N.S., Soergel P., Peterson K. Neutrophils and low-grade inflammation in the seemingly normal aging human lung. Mech. Aging Develop. 104:1998;169-181.
48. Nakayama K., Jia Y.X., Hirai H., Shinkawa M., Yamaya M., Sekizawa K., Sasaki H. Acid stimulation reduces bactericidal activity of surface liquid in cultured human airway epithelial cells. Am. J. Respir. Crit. Care Med. 26:2002;105-113.
49. National Vital Statistics Report 49 (11) 1-49; October 12, 2001.
50. Nichol K.L., Margolis K.L., Wuorenma J., Von Sternberg T. The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community. N. Engl. J. Med. 331:1994;778-784.
51. Nicolau D. Clinical and economic implications of antimicrobial resistance for the management of community-acquired respiratory tract infections. J. Antimicrob. Chemother. 50:2002;S61-S70.
52. Örtqvist Å. Pneumococcal vaccination: current and future issues. Eur. Respir. J. 18:2001;184-195.
53. Palmer L.B., Albulak K., Fields S., Filkin A.M., Simon S., Smaldone G.C. Oral clearance and pathogenic oropharyngeal colonization in the elderly. Am. J. Respir. Crit. Care Med. 164:2001;464-468.
54. Pamuk E.R., Williamson D.F., Serdula M.K., Madans J., Byers T.E. Weight loss and subsequent death in a cohort of U.S. adults. Ann. Intern. Med. 119:1993;744-748.
55. Polkey M.I., Harris M.L., Hughes P.D., Hamnegard C.H., Lyons D., Green M., Moxham J. The contractile properties of the elderly human diaphragm. Am. J. Respir. Crit. Care Med. 155:1997;1560-1564.
56. Puchelle E., Zahm J.M., Bertrand A. Influence of age on bronchial mucociliary transport. Scand. J. Respir. Dis. 60:1979;307-313.
57. Reiser K.M., Hennessy S.M., Last J.A. Analysis of age-associated changes in collagen crosslinking in the skin and lung in monkeys and rats. Biochim. Biophys. Acta. 926:1987;339-348.
58. Riquelme R., Torres A., El-Ebiary M., de la Bellacasa J.P., Estruch R., Mensa J., Fernandez-Sola J., Hernandez C., Rodriguez-Roisin R. Community-acquired pneumonia in the elderly: a multivariate analysis of risk and prognostic factors. Am. J. Respir. Crit. Care Medicine. 154:1996;1450-1455.
59. Rossi A., Ganassini A., Tantucci C., Grassi V. Aging and the respiratory system. Aging Clin. Exp. Res. 8:1996;143-161.
60. Rubland J., Griffin W.M., Cole P.J. Human ciliary beat frequency in epithelium from intrathoracic and extrathoracic airways. Am. Rev. Respir. Crit. Care Med. 125:1982;100-105.
61. Ruiz M., Ewig S., Marcos M.A., Martinez J.A., Arancibia F., Mensa J., Torres A. Etiology of community-acquired pneumonia: impact of age, comorbidity, and severity. Am. J. Respir. Crit. Care Med. 160:1999;397-405.
62. Shaker R., Staff D. Esophageal disorders in the elderly. Gastroent. Clin. N. Am. 30:2001;335-361.
63. Shaker R., Ren J., Bardan E., Easterling C., Dua K., Xie P., Kern M. Pharyngoglottal closure reflex: characterization in healthy young, elderly and dysphagic patients with predeglutitive aspiration. Gerontology. 49:2003;12-20.
64. Simberkoff M.S., Cross A.P., Al-Ibrahim M., Baltch A.L., Greiseler P.J., Nadler J., Richmond A.S., Smith R.P., Schiffman G., Shepard D.S. Efficacy of pneumococcal vaccine in high risk patients: results of a Veterans Administration cooperative study. N. Engl. J. Med. 315:1986;1318-1327.
65. Sisk J.E., Moskowitz A.J., Whang W., Lin J.D., Fedson D.S., McBean A.M., Plouffe J.F., Cetron M.S., Butler J.C. Cost-effectiveness of vaccination against pneumococcal bacteremia among elderly people. JAMA. 278:1997;1333-1339.
66. Smaldone G.C. Deposition and clearance: unique problems in the proximal airways and oral cavity in the young and elderly. Respir. Physiol. 128:2001;33-38.
67. Solana R., Mariani E. NK and NK/T cells in human senescence. Vaccine. 18:2000;1613-1620.
68. Song H., Price P.W., Cerny J. Age-related changes in antibody repertoire: contribution from T-cells. Immunol. Rev. 160:1997;55-62.
69. Starczewski A.R., Allen S.C., Vargas E., Lye M. Clinical prognostic indices of fatality in elderly patients admitted to hospital with acute pneumonia. Age & Ageing. 17:1988;181-186.
70. Strausbaugh L.J., Sukumar S.R., Joseph C.L. Infectious disease outbreaks in nursing homes: an unappreciated hazard for frail elderly persons. Clin. Infect. Dis. 36:2003;870-876.
71. Teramoto S., Matsuse T., Oka T., Ito H., Fukuchi Y., Ouchi Y. Invfestigation of effects of anesthesia and age on aspiration in mice through LacZ gene transfer by recombinant E1-deleted adenovirus vectors. Am. J. Respir. Crit. Care Med. 158:1998;1914-1919.
72. Thompson A.B., Scholer S.G., Daughton D.M., Potter J.F., Rennard S.I. Altered epithelial lining fluid parameters in old normal individuals. J. Gerontol. 47:1992;M171-M176.
73. Tolep K., HIggins N., Muza S., Criner G., Kelsen S.G. Comparison of diaphragm strength between healthy adult elderly and young men. Am. J. Respir. Crit. Care Med. 152:1995;677-682.
74. Treanor J., Falsey A. Respiratory viral infections in the elderly. Antiviral Res. 44:1999;79-102.
75. Treanor J.J., Hayden F.G., Vrooman P.S., Barbarash R., Betts R., Riff D., Singh S., Kinnersley N., Ward P., Mills R.G. Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. JAMA. 283:2000;1016-1024.
76. Verdery R.B. Malnutrition and chronic inflammation: causes or effects of frailty? Aging. 4:1992;262-263.
77. Whitney C.G., Farley M.M., Hadler J., Harrison L.H., Lexau C., Reingold A., Lefkowitz L., Cieslak P.R., Cetron M., Zell E.R., Jorgensen J.H., Schuchat A. Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States. N. Engl. J. Med. 343:2000;1917-1924.
78. Woodhead M. Pneumonia in the elderly. J. Antimicrob. Chemother. 34(S):1994;85-92.
79. Yeh S., Schuster M.W. Geriatric cachexia: the role of cytokines. Am. J. Clin. Nutr. 70:1999;183-197.