Crystal Structure of a cAMP-dependent Protein Kinase Mutant at 1.26 Å: New Insights into the Catalytic Mechanism

Journal of Molecular Biology

Volumn 336, Issue 2, 2004, Pages 473-487

  Yang, Jie ^a   Ten Eyck, Lynn F ^a,b   Xuong, Nguyen Huu ^a   Taylor, Susan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cAMP dependent protein kinase; Catalytic mechanism; Crystal structure; Hydrophobic core; P + 1 loop

Indexed keywords

ADENOSINE TRIPHOSPHATE MAGNESIUM; ARGININE; ASPARAGINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; LEUCINE; MUTANT PROTEIN; TYROSINE;

ALPHA HELIX; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

EID: 0742324523     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2003.11.044     Document Type: Article

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