The structure of Sky1p reveals a novel mechanism for constitutive activity

Nature Structural Biology

Volumn 8, Issue 2, 2001, Pages 176-183

  Nolen, Brad ^a   Yun, Chi Y ^b   Wong, Chung F ^c   Andrew McCammon, J ^a,c   Fu, Xiang Dong ^b   Ghosh, Gourisankar ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE; PROTEIN KINASE SKY1P; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA PROCESSING; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ENZYME ACTIVATION; FUNGAL PROTEINS; GENES, LETHAL; GLUTAMINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; REPETITIVE SEQUENCES, AMINO ACID; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0035155003     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/84178     Document Type: Article

References (39)

1. A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding
2. Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing
3. Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors
4. Conservation in budding yeast of a kinase specific for SR splicing factors
5. Isolation and characterization of Saccharornyces cerevisiae mRNA transport-defective (mtr) mutants
6. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export
7. Conserved SR protein kinase is involved in regulated nuclear import and its action is counteracted by arginine methylation in S. cerevisiae
8. SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors
9. SRPK2: A differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells
10. Three protein kinase structures define a common motif
11. Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
12. Crystal structure of JNK3: A kinase implicated in neuronal apoptosis
13. The structure of phosphorylated P38-gamma is monomeric and reveals a conserved activation-loop conformation
14. 2.2 Å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor
15. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
16. Bound to activate: Conformational consequences of cyclin binding to CDK2
17. Catalytic subunit of cyclic AMP-dependent protein kinase: Structure and dynamics of the active site cleft
18. Active and inactive protein kinases: Structural basis for regulation
19. The structural basis for substrate recognition and control by protein kinases
20. Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 angstrom resolution
21. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases
22. Crystal structure of cyclin-dependent kinase 2
23. Crystal structure of p38 mitogen-activated protein kinase
24. The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution
25. Activity of the MAP kinase ERK2 is controlled by a flexible surface loop
26. Multisite and hierarchical protein phosphorytation
27. SR protein kinases: The splice of life
28. Processing of X-ray diffraction data collected in oscillation mode
29. Automated MAD and MIR structure solution
30. Maximun-likelihood heavy-atom parameter refinement in the MIR and MAD methods
31. Improved methods for building protein models in electron density maps and the location of errors in these models
32. Crystallography and NMR system: A new software suite for macromolecular structure determination
33. PROCHECK: A program to check the stereochemical quality of protein structures
34. Mechanism of IκBα binding to NFκB dimers
35. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
36. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
37. Raster3d version 2.0 - A program for photorealistic molecular graphics
38. Electrostatics and diffusion of molecules in solution: Simulations with the University of Houston Brownian Dynamics program
39. Protein folding and association - Insights from the interfacial and thermodynamic properties of hydrocarbons