Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma

Journal of Interferon and Cytokine Research

Volumn 20, Issue 11, 2000, Pages 935-946

  Le, X ^a   Shi, Q ^a   Wang, B ^a   Xiong, Q ^a   Qian, C ^a,b   Peng, Z ^c   Li, X C ^d   Tang, H ^c   Abbruzzese, J L ^a   Xie, K ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 8;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELETION MUTANT; ENZYME LINKED IMMUNOSORBENT ASSAY; HALF LIFE TIME; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PANCREAS CARCINOMA; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

ADENOCARCINOMA; CCAAT-ENHANCER-BINDING PROTEIN-BETA; HUMANS; INTERLEUKIN-8; NF-KAPPA B; PANCREATIC NEOPLASMS; PROMOTER REGIONS (GENETICS); RNA STABILITY; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED;

EID: 0033659073     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/10799900050198372     Document Type: Article

References (62)

1. Experimental animal models for pancreatic cancer
2. Role of growth factors in pancreatic cancer
3. Advances from genetic clues in pancreatic cancer
4. Interleukin-6 produced by pancreatic carcinoma cells enhances humoral immune responses against tumor cells: A possible event in tumor regression
5. Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma
6. Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice
7. Detection of interleukin-8 mRNA and protein in human colorectal carcinoma cells
8. Expression of interleukin-8 receptors on tumor cells and vascular endothelial cells in human breast cancer tissue
9. Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice
10. Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice
11. Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization technique
12. Expression of interleukin-8 correlates with vascularity in human gastric carcinomas
13. IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor
14. Interleukin 8: An autocrine growth factor for malignant mesothelioma
15. Expression and growth-promoting function of the IL-8 receptor beta in human melanoma cells
16. Growth inhibition of human glioma cells modulated by retrovirus gene transfection with antisense IL-8
17. Interleukin-8 as a macrophage-derived mediator of angiogenesis
18. Interleukin-8. A corneal factor that induces neovascularization
19. Interleukin-8 stimulates angiogenesis in rats
20. Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis
21. Macrophages and angiogenesis
22. IL-8 and angiogenesis: Evidence that human endothelial cells lack receptors and do not respond to IL-8 in vitro
23. Interleukin-8 and de novo mammalian angiogenesis
24. Angiogenesis in mesotheliomas: Role of mesothelial cell derived IL-8
25. Constitutive and inducible interleukin-8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic
26. Interleukin 8 and MCAF: Novel inflammatory cytokines inducible by IL 1 and TNF
27. Interleukin-8: A review
28. Molecular mechanism of interleukin-8 gene expression
29. Interleukin-8 and the chemokine family
30. Role of interleukin-8 in tumor growth and metastasis of human melanoma
31. Heterogeneity of potential for hematogenous metastasis in a human pancreatic carcinoma
32. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
33. Cooperation between transcription factor AP-1 and NF-kappaB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia
34. Loss of AP-2 results in downregulation of c-kit and enhancement of melanoma tumorigenicity and metastasis
35. Suppression of TNF-α-induced apoptosis by NF-κB
36. Improved retroviral vectors for gene transfer and expression
37. Nuclear factor-κB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice
38. Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth
39. Rel/NF-κB/IκB proteins and cancer
40. Enhanced degradation of I-κB alpha contributes to endogenous activation of NF-kappaB in Hs294T melanoma cells
41. The hose environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma
42. Polyphenol-mediated inhibition of AP-1 transactivating activity may slow cancer growth by impeding angiogenesis and tumor invasiveness
43. The ying-yang of RAR and AP-1: Cancer treatment without overt toxicity
44. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
45. Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis
46. The role of cytokines in pancreatic cancer
47. Regulation of interleukin-8 expression in human melanoma cells by the organ environment
48. Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis
49. Induction and regulation of interleukin-8 gene expression
50. Molecular mechanism of interleukin-8 gene expression
51. Transcriptional and post-transcriptional regulation of interleukin-8
52. Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression
53. Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (Re1A) and NF-IL-6
54. Essential role of transcription factor nuclear factor-kappaB in regulation of interleukin-8 gene expression by nitrite reductase from Pseudomonas aeruginosa in respiratory epithelial cells
55. The NF-κB and IκB proteins: New discoveries and insights
56. Nuclear factor-kappa B: A pivotal transcription factor in chronic inflammatory diseases
57. The I kappa B proteins: Multifunctional regulators of Re1/NF-κB transcription factors
58. Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-κB activation
59. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
60. Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli
61. TNF and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB
62. Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic Ras