NMR Structural Characterization of Peptide Inhibitors Bound to the Hepatitis C Virus NS3 Protease: Design of a New P2 Substituent

Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2004, Pages 123-132

  Goudreau, Nathalie ^a   Cameron, Dale R ^a,b   Bonneau, Pierre ^a   Gorys, Vida ^a   Plouffe, Céline ^a   Poirier, Martin ^a   Lamarre, Daniel ^a   Llinas Brunet, Montse ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^b Migenix Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROLINE; PROTEIN INHIBITOR; TETRAPEPTIDE; VIRUS PROTEIN;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SPECIFICITY; DRUG STABILITY; DRUG STRUCTURE; ENZYME SUBSTRATE; EXPERIMENT; HEPATITIS C VIRUS; HYPOTHESIS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; STRUCTURE ANALYSIS;

DRUG DESIGN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; OLIGOPEPTIDES; PROLINE; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0347991962     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0303002     Document Type: Article

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