Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework

Journal of Medicinal Chemistry

Volumn 40, Issue 12, 1997, Pages 1794-1807

  Giardina, Giuseppe A M ^a   Sarau, Henry M ^b   Farina, Carlo ^a   Medhurst, Andrew D ^b   Grugni, Mario ^a   Raveglia, Luca F ^a   Schmidt, Dulcie B ^b   Rigolio, Roberto ^a   Luttmann, Mark ^b   Vecchietti, Vittorio ^a   Hay, Douglas W P ^b  

^a SmithKline Beecham SpA   (Italy)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; 2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; N [ALPHA (METHOXYCARBONYL)BENZYL] 2 PHENYL 4 QUINOLINECARBOXAMIDE; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR ANTAGONIST; NEUROKININ A; NEUROKININ B; QUINOLINE DERIVATIVE; SENKTIDE; SUBSTANCE P; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG COMPETITION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; NONHUMAN; RABBIT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; SPHINCTER PUPILLAE MUSCLE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CHEMISTRY, PHYSICAL; CHO CELLS; CRICETINAE; HUMANS; HYDROGEN BONDING; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; PEPTIDE FRAGMENTS; QUINOLINES; RABBITS; RECEPTORS, NEUROKININ-3; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTANCE P;

EID: 14444269664     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960818o     Document Type: Article

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