Understanding the Transition States of Phosphodiester Bond Cleavage: Insights from Heavy Atom Isotope Effects

Biopolymers

Volumn 73, Issue 1, 2004, Pages 110-129

  Cassano, Adam G ^a   Anderson, Vernon E ^a   Harris, Michael E ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Enzyme catalysis; Isotope effect; Phosphodiesterase; Transition state

Indexed keywords

CATALYSIS; DNA; ENZYMES; RNA; SYNTHESIS (CHEMICAL);

TRANSITION STATES;

BIOPOLYMERS;

DNA; ESTER DERIVATIVE; HYDROXIDE; HYDROXYL GROUP; METAL ION; PHOSPHATE; PHOSPHODIESTERASE; RNA;

ACID BASE BALANCE; CHEMICAL ANALYSIS; CHEMICAL BOND; DNA SYNTHESIS; ENZYME ACTIVE SITE; ENZYME MECHANISM; HYDROLYSIS; MOLECULAR INTERACTION; REVIEW; RNA SYNTHESIS;

BASE COMPOSITION; BINDING SITES; CATALYSIS; DNA; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; HYDROXIDES; IONS; ISOTOPES; KINETICS; MODELS, CHEMICAL; NUCLEIC ACIDS; RNA; THIONUCLEOTIDES;

EID: 0347763703     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.10517     Document Type: Review

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