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Volumn 40, Issue 37, 2001, Pages 10911-10926
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The Tetrahymena ribozyme cleaves a 5′-methylene phosphonate monoester ∼102-fold faster than a normal phosphate diester: Implications for enzyme catalysis of phosphoryl transfer reactions
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Author keywords
[No Author keywords available]
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Indexed keywords
ENZYME CATALYSIS;
DNA;
ESTERS;
OXYGEN;
PHOSPHATES;
RNA;
SUBSTRATES;
CATALYSIS;
5' METHYLENEPHOSPHONIC ACID ESTER;
DNA;
ETHYLPHOSPHONATE;
METAL ION;
METHYLPHOSPHATE;
OLIGONUCLEOTIDE;
ORGANOPHOSPHATE;
OXYGEN;
PHOSPHATE;
PHOSPHONIC ACID DERIVATIVE;
PHOSPHORUS;
RIBOZYME;
RNA;
THYMIDINE;
UNCLASSIFIED DRUG;
ARTICLE;
CATALYSIS;
CHEMICAL REACTION;
CHEMICAL REACTION KINETICS;
CHEMICAL STRUCTURE;
CHIMERA;
CONTROLLED STUDY;
ENZYME KINETICS;
GEOMETRY;
HYDROGEN BOND;
MICHAELIS CONSTANT;
PHOSPHATE TRANSPORT;
PRIORITY JOURNAL;
REACTION ANALYSIS;
STRUCTURE ACTIVITY RELATION;
TETRAHYMENA;
ANIMALS;
CATALYSIS;
ESTERS;
KINETICS;
MODELS, CHEMICAL;
MOLECULAR PROBES;
OLIGONUCLEOTIDES;
PHOSPHONIC ACIDS;
RNA, CATALYTIC;
SUBSTRATE SPECIFICITY;
TETRAHYMENA THERMOPHILA;
THERMODYNAMICS;
TETRAHYMENA;
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EID: 0035909060
PISSN: 00062960
EISSN: None
Source Type: Journal
DOI: 10.1021/bi010801u Document Type: Article |
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Times cited : (13)
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References (77)
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