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A thoughtful discussion of one- and two-ion mechanisms for the hammerhead ribozyme
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The introduction of abasic sites into the core of the hammerhead ribozyme leads to a large reduction in catalytic efficiency in most positions. These data are interpreted in terms of a 'core folding' model, in which the ribozyme must undergo a further conformational change to achieve an active geometry
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Molecular dynamics simulation starting from the structure of the hammerhead ribozyme in flash-frozen crystals
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Numbering system for the hammerhead
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