-
1
-
-
0034090097
-
Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
-
Griffoen AW, Molema G. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 2000;52:237-68.
-
(2000)
Pharmacol Rev
, vol.52
, pp. 237-268
-
-
Griffoen, A.W.1
Molema, G.2
-
3
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension
-
Jiang BH, Zheng JZ, Leung SW, et al. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. J Biol Chem 1997;272:19253-60.
-
(1997)
J Biol Chem
, vol.272
, pp. 19253-19260
-
-
Jiang, B.H.1
Zheng, J.Z.2
Leung, S.W.3
-
4
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
-
5
-
-
0035347260
-
Induction of HIF-1alpha in response to hypoxia is instantaneous
-
Jewell UR, Kvietikova I, Scheid A, et al. Induction of HIF-1alpha in response to hypoxia is instantaneous. FASEB J 2001;15:1312-4.
-
(2001)
FASEB J
, vol.15
, pp. 1312-1314
-
-
Jewell, U.R.1
Kvietikova, I.2
Scheid, A.3
-
6
-
-
0031733828
-
Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha
-
Gu YZ, Moran SM, Hogenesch JB, et al. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr 1998;7:205-13.
-
(1998)
Gene Expr
, vol.7
, pp. 205-213
-
-
Gu, Y.Z.1
Moran, S.M.2
Hogenesch, J.B.3
-
7
-
-
0034920196
-
Hypoxia regulation of gene transcription
-
Caro J. Hypoxia regulation of gene transcription. High Alt Med Biol 2001;2:145-54.
-
(2001)
High Alt Med Biol
, vol.2
, pp. 145-154
-
-
Caro, J.1
-
8
-
-
0037277741
-
Vascular endothelial growth factors and angiogenesis in eye disease
-
Witmer AN, Vrensen GF, Van Noorden CJ, et al. Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res 2003;22:1-29.
-
(2003)
Prog Retin Eye Res
, vol.22
, pp. 1-29
-
-
Witmer, A.N.1
Vrensen, G.F.2
Van Noorden, C.J.3
-
9
-
-
0030772252
-
Vascular endothelial growth factor
-
Plate KH, Warnke PC. Vascular endothelial growth factor. J Neurooncol 1997;35:365-72.
-
(1997)
J Neurooncol
, vol.35
, pp. 365-372
-
-
Plate, K.H.1
Warnke, P.C.2
-
10
-
-
0034282885
-
The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1
-
Fuh G, Garcia KC, de Vos AM. The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1. J Biol Chem 2000;275:26690-5.
-
(2000)
J Biol Chem
, vol.275
, pp. 26690-26695
-
-
Fuh, G.1
Garcia, K.C.2
De Vos, A.M.3
-
11
-
-
0027997863
-
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
-
Waltenberger J, Claesson-Welsh L, Siegbahn A, et al. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 1994;269:26988-95.
-
(1994)
J Biol Chem
, vol.269
, pp. 26988-26995
-
-
Waltenberger, J.1
Claesson-Welsh, L.2
Siegbahn, A.3
-
12
-
-
0036014909
-
Vascular endothelial growth factor gene regulation and action in diabetic retinopathy
-
Lu M, Adamis AP. Vascular endothelial growth factor gene regulation and action in diabetic retinopathy. Ophthalmol Clin N Am 2002;15:69-79.
-
(2002)
Ophthalmol Clin N Am
, vol.15
, pp. 69-79
-
-
Lu, M.1
Adamis, A.P.2
-
13
-
-
0036892770
-
Vascular growth factors for coronary angiogenesis
-
Lee CH, Smits PC. Vascular growth factors for coronary angiogenesis. J Interv Cardiol 2002;15:511-8.
-
(2002)
J Interv Cardiol
, vol.15
, pp. 511-518
-
-
Lee, C.H.1
Smits, P.C.2
-
14
-
-
0037162031
-
Lipid mediators of angiogenesis and the signalling pathways they initiate
-
English D, Brindley DN, Spiegel S, et al. Lipid mediators of angiogenesis and the signalling pathways they initiate. Biochim Biophys Acta 2002;1582:228-39.
-
(2002)
Biochim Biophys Acta
, vol.1582
, pp. 228-239
-
-
English, D.1
Brindley, D.N.2
Spiegel, S.3
-
15
-
-
0036315547
-
Antiangiogenic therapy targeting factors that enhance endothelial cell survival
-
Liu W, Reinmuth N, Stoeltzing O, et al. Antiangiogenic therapy targeting factors that enhance endothelial cell survival. Semin Oncol 2002;29:96-103.
-
(2002)
Semin Oncol
, vol.29
, pp. 96-103
-
-
Liu, W.1
Reinmuth, N.2
Stoeltzing, O.3
-
16
-
-
0035145117
-
Angiopoietin growth factors and Tie receptor tyrosine kinases in renal vascular development
-
Woolf AS, Yuan HT. Angiopoietin growth factors and Tie receptor tyrosine kinases in renal vascular development. Pediatr Nephrol 2001;16:177-84.
-
(2001)
Pediatr Nephrol
, vol.16
, pp. 177-184
-
-
Woolf, A.S.1
Yuan, H.T.2
-
17
-
-
0035318510
-
Tie receptors: New modulators of angiogenic and lymphangiogenic responses
-
Jones N, Iljin K, Dumont DJ, et al. Tie receptors: new modulators of angiogenic and lymphangiogenic responses. Nat Rev Mol Cell Biol 2001;2:257-67.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 257-267
-
-
Jones, N.1
Iljin, K.2
Dumont, D.J.3
-
18
-
-
0037223577
-
Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix
-
Li J, Zhang YP, Kirsner RS. Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix. Microsc Res Tech 2003;60:107-14.
-
(2003)
Microsc Res Tech
, vol.60
, pp. 107-114
-
-
Li, J.1
Zhang, Y.P.2
Kirsner, R.S.3
-
20
-
-
0030901104
-
Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3
-
Anand-Apte B, Pepper MS, Voest E, et al. Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3. Invest Ophthalmol Vis Sci 1997;38:817-23.
-
(1997)
Invest Ophthalmol Vis Sci
, vol.38
, pp. 817-823
-
-
Anand-Apte, B.1
Pepper, M.S.2
Voest, E.3
-
22
-
-
0033588371
-
On the mechanism of thrombin-induced angiogenesis. Potentiation of vascular endothelial growth factor activity on endothelial cells by up-regulation of its receptors
-
Tsopanoglou NE, Maragoudakis ME. On the mechanism of thrombin-induced angiogenesis. Potentiation of vascular endothelial growth factor activity on endothelial cells by up-regulation of its receptors. J Biol Chem 1999;274:23969-76.
-
(1999)
J Biol Chem
, vol.274
, pp. 23969-23976
-
-
Tsopanoglou, N.E.1
Maragoudakis, M.E.2
-
23
-
-
0035524007
-
Integrins as targets of angiogenesis inhibition
-
Westlin WF. Integrins as targets of angiogenesis inhibition. Cancer J 2001;7(Suppl 3):S139-43.
-
(2001)
Cancer J
, vol.7
, Issue.SUPPL. 3
-
-
Westlin, W.F.1
-
24
-
-
0035988822
-
Laminin isoforms in tumor invasion, angiogenesis and metastasis
-
Patarroyo M, Tryggvason K, Virtanen I. Laminin isoforms in tumor invasion, angiogenesis and metastasis. Semin Cancer Biol 2002;12:197-207.
-
(2002)
Semin Cancer Biol
, vol.12
, pp. 197-207
-
-
Patarroyo, M.1
Tryggvason, K.2
Virtanen, I.3
-
25
-
-
0036734093
-
A reevaluation of integrins as regulators of angiogenesis
-
Hynes RO. A reevaluation of integrins as regulators of angiogenesis. Nat Med 2002;8:918-21.
-
(2002)
Nat Med
, vol.8
, pp. 918-921
-
-
Hynes, R.O.1
-
26
-
-
0036300131
-
PEDF: Anti-angiogenic guardian of ocular function
-
Bouck N. PEDF: anti-angiogenic guardian of ocular function. Trends Mol Med 2002;8:330-4.
-
(2002)
Trends Mol Med
, vol.8
, pp. 330-334
-
-
Bouck, N.1
-
27
-
-
0033538517
-
Pigment epithelium-derived factor: A potent inhibitor of angiogenesis
-
Dawson DW, Volpert OV, Gillis P, et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999;285:245-8.
-
(1999)
Science
, vol.285
, pp. 245-248
-
-
Dawson, D.W.1
Volpert, O.V.2
Gillis, P.3
-
28
-
-
0034307757
-
Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal
-
Jablonski MM, Tombran-Tink J, Mrazek DA, et al. Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal. J Neurosci 2000;20:7149-57.
-
(2000)
J Neurosci
, vol.20
, pp. 7149-7157
-
-
Jablonski, M.M.1
Tombran-Tink, J.2
Mrazek, D.A.3
-
29
-
-
0033428112
-
Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations
-
Cayouette M, Smith SB, Becerra SP, et al. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 1999;6:523-32.
-
(1999)
Neurobiol Dis
, vol.6
, pp. 523-532
-
-
Cayouette, M.1
Smith, S.B.2
Becerra, S.P.3
-
30
-
-
0032549956
-
Structural and comparative analysis of the mouse gene for pigment epithelium-derived factor (PEDF)
-
Singh VK, Chader GJ, Rodriguez IR. Structural and comparative analysis of the mouse gene for pigment epithelium-derived factor (PEDF). Mol Vis 1998;4:7-11.
-
(1998)
Mol Vis
, vol.4
, pp. 7-11
-
-
Singh, V.K.1
Chader, G.J.2
Rodriguez, I.R.3
-
31
-
-
0036104828
-
Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor
-
Volpert OV, Zaichuk T, Zhou W, et al. Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat Med 2002;8:349-57.
-
(2002)
Nat Med
, vol.8
, pp. 349-357
-
-
Volpert, O.V.1
Zaichuk, T.2
Zhou, W.3
-
32
-
-
0034833822
-
CD36: A class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
-
Febbraio M, Hajjar DP, Silverstein RL. CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. J Clin Invest 2001;108:785-91.
-
(2001)
J Clin Invest
, vol.108
, pp. 785-791
-
-
Febbraio, M.1
Hajjar, D.P.2
Silverstein, R.L.3
-
34
-
-
0037039350
-
A fragment of human TrpRS as a potent antagonist of ocular angiogenesis
-
Otani A, Slike BM, Dorrell MI, et al. A fragment of human TrpRS as a potent antagonist of ocular angiogenesis. Proc Natl Acad Sci U S A 2002;99:178-83.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 178-183
-
-
Otani, A.1
Slike, B.M.2
Dorrell, M.I.3
-
36
-
-
0035941054
-
The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells
-
Spinetti G, Camarda G, Bernardini G, et al. The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells. Biochem Biophys Res Commun 2001;289:19-24.
-
(2001)
Biochem Biophys Res Commun
, vol.289
, pp. 19-24
-
-
Spinetti, G.1
Camarda, G.2
Bernardini, G.3
-
37
-
-
0037378411
-
Current and future strategies for the treatment of malignant brain tumors
-
Castro MG, Cowen R, Williamson IK, et al. Current and future strategies for the treatment of malignant brain tumors. Pharmacol Ther 2003;98:71-108.
-
(2003)
Pharmacol Ther
, vol.98
, pp. 71-108
-
-
Castro, M.G.1
Cowen, R.2
Williamson, I.K.3
-
41
-
-
0036937105
-
Diabetic macular edema: Review and update
-
Pelzek C, Lim JI. Diabetic macular edema: review and update. Ophthalmol Clin N Am 2002;15:555-63.
-
(2002)
Ophthalmol Clin N Am
, vol.15
, pp. 555-563
-
-
Pelzek, C.1
Lim, J.I.2
-
42
-
-
0036728609
-
Polycistronic viral vectors
-
de Felipe P. Polycistronic viral vectors. Curr Gene Ther 2002;2:355-78.
-
(2002)
Curr Gene Ther
, vol.2
, pp. 355-378
-
-
De Felipe, P.1
-
43
-
-
0035698574
-
Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells
-
Post DE, Van Meir EG. Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells. Gene Ther 2001;8:1801-7.
-
(2001)
Gene Ther
, vol.8
, pp. 1801-1807
-
-
Post, D.E.1
Van Meir, E.G.2
-
44
-
-
0036968555
-
Lentiviral vectors for gene delivery into cells
-
Quinonez R, Sutton RE. Lentiviral vectors for gene delivery into cells. DNA Cell Biol 2002;21:937-51.
-
(2002)
DNA Cell Biol
, vol.21
, pp. 937-951
-
-
Quinonez, R.1
Sutton, R.E.2
-
45
-
-
0035476509
-
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha
-
Elson DA, Thurston G, Huang LE, et al. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha. Genes Dev 2001;15:2520-32.
-
(2001)
Genes Dev
, vol.15
, pp. 2520-2532
-
-
Elson, D.A.1
Thurston, G.2
Huang, L.E.3
-
46
-
-
0036873485
-
Harnessing the response to tissue hypoxia: HIF-1 alpha and therapeutic angiogenesis
-
Vincent KA, Feron O, Kelly RA. Harnessing the response to tissue hypoxia: HIF-1 alpha and therapeutic angiogenesis. Trends Cardiovasc Med 2002;12:362-7.
-
(2002)
Trends Cardiovasc Med
, vol.12
, pp. 362-367
-
-
Vincent, K.A.1
Feron, O.2
Kelly, R.A.3
-
47
-
-
0034739533
-
Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor
-
Vincent KA, Shyu KG, Luo Y, et al. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor. Circulation 2000;102:2255-61.
-
(2000)
Circulation
, vol.102
, pp. 2255-2261
-
-
Vincent, K.A.1
Shyu, K.G.2
Luo, Y.3
-
48
-
-
0034978562
-
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
-
Oosthuyse B, Moons L, Storkebaum E, et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 2001;28:131-8.
-
(2001)
Nat Genet
, vol.28
, pp. 131-138
-
-
Oosthuyse, B.1
Moons, L.2
Storkebaum, E.3
-
49
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, Mole DR, Tian YM, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-72.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
-
50
-
-
0031596117
-
Role of NF-kappaB-mediated interleukin-8 expression in intraocular neovascularization
-
Yoshida A, Yoshida S, Khalil AK, et al. Role of NF-kappaB-mediated interleukin-8 expression in intraocular neovascularization. Invest Ophthalmol Vis Sci 1998;39:1097-106.
-
(1998)
Invest Ophthalmol Vis Sci
, vol.39
, pp. 1097-1106
-
-
Yoshida, A.1
Yoshida, S.2
Khalil, A.K.3
-
51
-
-
0035654217
-
Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease
-
Spranger J, Osterhoff M, Reimann M, et al. Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. Diabetes 2001;50:2641-5.
-
(2001)
Diabetes
, vol.50
, pp. 2641-2645
-
-
Spranger, J.1
Osterhoff, M.2
Reimann, M.3
-
52
-
-
0035514256
-
Clinical protocol. An open-label, phase I, single administration, dose-escalation ADGVPEDF study of, 11D (ADPEDF) in neovascular age-related macular degeneration (AMD)
-
Rasmussen H, Chu KW, Campochiaro P, et al. Clinical protocol. An open-label, phase I, single administration, dose-escalation ADGVPEDF study of, 11D (ADPEDF) in neovascular age-related macular degeneration (AMD). Hum Gene Ther 2001;12:2029-32.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 2029-2032
-
-
Rasmussen, H.1
Chu, K.W.2
Campochiaro, P.3
-
53
-
-
0031019745
-
Isolation of putative progenitor endothelial cells for angiogenesis
-
Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-7.
-
(1997)
Science
, vol.275
, pp. 964-967
-
-
Asahara, T.1
Murohara, T.2
Sullivan, A.3
-
54
-
-
0036732459
-
Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis
-
Otani A, Kinder K, Ewalt K, et al. Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis. Nat Med 2002;8:1004-10.
-
(2002)
Nat Med
, vol.8
, pp. 1004-1010
-
-
Otani, A.1
Kinder, K.2
Ewalt, K.3
-
55
-
-
0034125929
-
Current status of antiangiogenic factors
-
Talks KL, Harris AL. Current status of antiangiogenic factors. Br J Haematol 2000;109:477-89.
-
(2000)
Br J Haematol
, vol.109
, pp. 477-489
-
-
Talks, K.L.1
Harris, A.L.2
-
56
-
-
0036959644
-
Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration
-
The Eyetech Study Group. Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina 2002;22:143-52. 2002.
-
(2002)
Retina
, vol.22
, pp. 143-152
-
-
-
57
-
-
0023626528
-
Angiostatic steroids. Method of discovery and mechanism of action
-
Folkman J, Ingber DE. Angiostatic steroids. Method of discovery and mechanism of action. Ann Surg 1987;206:374-83.
-
(1987)
Ann Surg
, vol.206
, pp. 374-383
-
-
Folkman, J.1
Ingber, D.E.2
-
58
-
-
0030758411
-
Vascular endothelial growth factor and the eye: Biochemical mechanisms of action and implications for novel therapies
-
Aiello LP. Vascular endothelial growth factor and the eye: biochemical mechanisms of action and implications for novel therapies. Ophthalmic Res 1997;29:354-62.
-
(1997)
Ophthalmic Res
, vol.29
, pp. 354-362
-
-
Aiello, L.P.1
-
59
-
-
0035344092
-
Nonvascular role for VEGF: VEGFR-1, 2 activity is critical for neural retinal development
-
Robinson GS, Ju M, Shih SC, et al. Nonvascular role for VEGF: VEGFR-1, 2 activity is critical for neural retinal development. FASEB J 2001;15:1215-7.
-
(2001)
FASEB J
, vol.15
, pp. 1215-1217
-
-
Robinson, G.S.1
Ju, M.2
Shih, S.C.3
-
60
-
-
0036083592
-
Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapy
-
Lai YK, Shen WY, Brankov M, et al. Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapy. Gene Ther 2002;9:804-13.
-
(2002)
Gene Ther
, vol.9
, pp. 804-813
-
-
Lai, Y.K.1
Shen, W.Y.2
Brankov, M.3
|