Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells

Gene Therapy

Volumn 8, Issue 23, 2001, Pages 1801-1807

  Post, D E ^a   Van Meir, E G ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

Gene delivery; Glioma; Hypoxia; Hypoxia inducible factor 1; Hypoxia responsive promoter; Tumor

Indexed keywords

BETA GALACTOSIDASE; CIS ACTING ELEMENT; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1; LUCIFERASE; OXYGEN; VASCULOTROPIN;

ARTICLE; CANCER CELL CULTURE; CELL HYPOXIA; CELL TRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENHANCER REGION; EXPRESSION VECTOR; GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION REGULATION; GENE TARGETING; GLIOMA; HUMAN; HUMAN CELL; HYPOXIA; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; REPORTER GENE;

CELL HYPOXIA; DNA-BINDING PROTEINS; ENDOTHELIAL GROWTH FACTORS; ERYTHROPOIETIN; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; GENETIC VECTORS; GLIOMA; HELIX-LOOP-HELIX MOTIFS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYMPHOKINES; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

VECTORS;

EID: 0035698574     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301605     Document Type: Article

References (19)

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19. Co-regulation of two gene activities by tetracycline via a bidirectional promoter