CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids

Drug Metabolism and Disposition

Volumn 31, Issue 4, 2003, Pages 432-438

  Nakamura, Hiroyoshi ^a   Torimoto, Nao ^b   Ishii, Itsuko ^b   Ariyoshi, Noritaka ^a   Nakasa, Hiromitsu ^a   Ohmori, Shigeru ^c   Kitada, Mitsukazu ^a  

^a CHIBA UNIVERSITY HOSPITAL   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c SHINSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

17 HYDROXYPREGNENOLONE; 17 HYDROXYPREGNENOLONE 3 SULFATE; ALDOSTERONE; ALPHA NAPHTHOFLAVONE; ANDROSTENEDIONE; CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; CYTOCHROME P450 3A4; CYTOCHROME P450 3A7; CYTOCHROME P450 ISOENZYME; ESTRADIOL; ESTRONE; HYDROCORTISONE; HYDROXYPROGESTERONE; PRASTERONE; PRASTERONE SULFATE; PREGNENOLONE; PREGNENOLONE SULFATE; PROGESTERONE; STEROID; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; EPOXIDATION; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL;

ANIMALS; ANTICONVULSANTS; ARYL HYDROCARBON HYDROXYLASES; ARYLSULFATASES; BENZOFLAVONES; CARBAMAZEPINE; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INSECTS; KINETICS; STEROID HYDROXYLASES; STEROIDS; STERYL-SULFATASE; SUBSTRATE SPECIFICITY;

SIGMOIDEA;

EID: 0242276321     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.4.432     Document Type: Article

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