Differential catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells

Biochimica et Biophysica Acta - General Subjects

Volumn 1380, Issue 3, 1998, Pages 297-304

  Ohmori, Shigeru ^a   Nakasa, Hiromitsu ^a   Asanome, Kazuki ^b   Kurose, Yasusi ^b   Ishii, Itsuko ^b   Hosokawa, Masakiyo ^b   Kitada, Mitsukazu ^a  

^a CHIBA UNIVERSITY HOSPITAL   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

(Human); Carbamazepine; COS 7 cell; CYP3A enzyme; CYP3A4; CYP3A5; CYP3A7; Expression; Steroid hydroxylation; Triazolam; Zonisamide

Indexed keywords

6BETA TESTOSTERONE; CARBAMAZEPINE 10,11 OXIDE; CYTOCHROME B5; CYTOCHROME C; CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; PRASTERONE; PRASTERONE SULFATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; STEROID MONOOXYGENASE; TRIAZOLAM; TROLEANDOMYCIN; UNCLASSIFIED DRUG; ZONISAMIDE;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA SEQUENCE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; STEROID HYDROXYLATION;

ADULT; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CATALYSIS; COS CELLS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEHYDROEPIANDROSTERONE; DNA, COMPLEMENTARY; ENZYME ACTIVATION; GENETIC VECTORS; HUMANS; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES, N-DEMETHYLATING; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY; TESTOSTERONE; TRANSFECTION; TRIAZOLAM; TROLEANDOMYCIN;

EID: 0032496311     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(97)00156-6     Document Type: Article

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