Rationale for targeting interleukin-17 in the lungs

Current Opinion in Investigational Drugs

Volumn 4, Issue 11, 2003, Pages 1304-1312

  Lindén, Anders ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Airway infection; Asthma; Bacteria; Bronchitis; COPD; Cytokine; Inflammation; Neutrophil; Pneum onia; Protease

Indexed keywords

ALPHA CHEMOKINE; CYTOKINE; DEXAMETHASONE; ELASTASE; FLUTICASONE; GAMMA INTERFERON; GELATINASE B; GLUCOCORTICOID; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR ANTIBODY; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; LEUKOTRIENE B4; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MUCIN; NEUTROPHIL COLLAGENASE; OKT 4; RECOMBINANT INTERLEUKIN 17; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ADULT RESPIRATORY DISTRESS SYNDROME; AIRWAY; ASTHMA; BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE SEVERITY; DRUG MECHANISM; GENE EXPRESSION; HUMAN; LEUKOCYTE ACTIVATION; LUNG; LUNG DISEASE; LUNG FUNCTION; NEUTROPHIL; NONHUMAN; PNEUMONIA; RESPIRATORY TRACT INFECTION; REVIEW; T LYMPHOCYTE;

ANIMALS; HUMANS; INTERLEUKIN-17; LUNG; LUNG DISEASES; NEUTROPHIL ACTIVATION; T-LYMPHOCYTES;

EID: 0346463316     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (131)

1. Rouvier E, Luciani MF, Mattei G, Denizot F, Golstein P: CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol (1993) 150(12):5445-5456. This paper was the first to describe the molecule that was subsequently named IL-17.
2. Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ: Human IL-17: A novel cytokine derived from T cells. J Immunol (1995) 155(12):5483-5486. This is the original paper describing the biology of IL-17.
3. Lindén A, Adachi M: Neutrophilic airway inflammation and IL-17. Allergy (2002) 57(9):769-775.
4. Dumont FJ: IL-17 cytokine/receptor families: Emerging targets for the modulation of inflammatory responses. Expert Opin Ther Pat (2003) 13(3):287-303.
5. Fahy JV, Kim KW, Liu J, Boushey HA: Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol (1995) 95(4):843-852.
6. Ordonez CL, Shaughnessy TE, Matthay MA, Fahy JV: Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. Am J Respir Crit Care Med (2000) 161(4 Pt 1):1185-1190.
7. 1-antitrypsin in sputum of asthmatic patients. Am J Respir Crit Care Med (1998) 157(2):505-511.
8. Lamblin C, Gosset P, Tillie-Leblond I, Saulnier F, Marquette C-H, Wallaert B, Tonnel AB: Bronchial neutrophilia in patients with noninfectious status asthmaticus. Am J Respir Crit Care Med (1998) 157(2):394-402.
9. Jatakanon A, Uasuf C, Maziak W, Lim S, Chung KF, Barnes PJ: Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med (1999) 160(5 Pt 1):1532-1539.
10. Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, Chu HW: Evidence that severe asthma can be divided into two inflammatory substypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med (1999) 160(3):1001-1008.
11. Betz R, Kohlhaufl M, Kassner G, Mullinger B, Maier K, Brand P, Weber N, Haussinger K, Heyder J, Frankenberger M: Increased sputum IL-8 and IL-5 in asymptomatic non-specific hyperresponsiveness. Lung (2001) 179(2):119-133.
12. Gaga M, Bentley AM, Humbert M, Barkans J, O'Brien F, Wathen CG, Kay AB, Durham SR: Increases in CD4+ T lymphocytes, macrophages, neutrophils and interleukin-8 positive cells in the airways of patients with bronchiectasis. Thorax (1998) 53(8):685-691.
13. Angrill J, Augusti C, De Celis R, Filella X, Rano A, Elena M, De La Bellacasa JP, Xaubet A, Torres A: Bronchial inflammation and colonization in patients with clinically stable bronchectasis. Am J Respir Crit Care Med (2001) 164(9):1628-1632.
14. Zheng L, Shum H, Tipoe GL, Leung R, Lam WK, Ooi GC, Tsang KW: Macrophages, neutrophils and tumor necrosis factor-α expression in bronchiectatic airways in vivo. Respir Med (2001) 95(10):792-798.
15. Saetta M, Turato G, Facchini FM, Corbino L, Lucchini RE, Casoni G, Maestrelli P, Mapp CE, Ciaccia A, Fabbri LM: Inflammatory cells in the bronchial glands of smokers with chronic bronchitis. Am J Respir Crit Care Med (1997) 156(5):1633-1639.
16. Riise GC, Ahlstedt S, Larsson S, Enander I, Jones I, Larsson P, Andersson B: Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid. Thorax (1995) 50(4):360-365.
17. Balbi B, Bason C, Balleari E, Fiasella F, Pesci A, Ghio A, Fabiano F: Increased bronchoalveolar granulocytes and granulocyte/macrophage colony-stimulating factor during exacerbations of chronic bronchitis. Eur Resp J (1997) 10(4):846-850.
18. Betsuyaku T, Nishimura M, Takeyabu K, Tanino M, Venge P, Xu S, Kawakami Y: Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema. Am J Respir Crit Care Med (1999) 159(6):1985-1991.
19. Aaron SD, Angel JB, Lunau M, Wright K, Fex C, Le Saux N, Dales RE: Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2001) 163(2):349-355.
20. Balzano G, Stefanelli F, Lorio C, De Felice A, Melillo EM, Martucci M, Melillo G: Eosinophilic inflammation in stable chronic obstructive pulmonary disease. Relationship with neutrophils and airway function. Am J Respir Crit Care Med (1999) 160(5 Pt 1):1486-1492.
21. Di Stefano A, Capelli A, Lusuardi M, Balbo P, Vecchio C, Maestrelli P, Mapp CE, Fabbri LM, Donner CF, Saetta M: Severity of airflow limitation is associated with severity of airway linflammation in smokers. Am J Respir Crit Care Med (1998) 158(4):1277-1285.
22. Soler N, Ewig S, Torres A, Filella X, Gonzalez J, Zaubet A: Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease. Eur Respir J (1999) 14(5):1015-1022.
23. Noguera A, Batle S, Miralles C, Iglesias J, Busquets X, MacNee W, Agusti AGN: Enhanced neutrophil response in chronic obstructive pulmonary disease. Thorax (2001) 56(6):432-437.
24. Koller DY, Urbanek R, Götz M: Increased degranulation of eosinophil and neutrophil granulocytes in cystic fibrosis. Am J Respir Crit Care Med (1995) 152(2):629-633.
25. Dakin CJ, Numa AH, Wang H, Morton JR, Vertzyas CC, Henry RL: Inflammation infection, and pulmonary function in infants and young children with cystic fibrosis. Am J Respir Crit Care Med (2002) 165(7):904-910.
26. Muhlebach MS, Noah TL: Endotoxin activity and inflammatory markers in the airways of young patients with cystic fibrosis. Am J Respir Crit Care Med (2002) 165(7):911-915.
27. Sagel SD, Kapsner R, Osberg I, Sontag MK, Accurso FJ: Airway inflammation in children with cystic fibrosis and healthy children assessed by sputum induction. Am J Respir Crit Care Med (2001) 164(8 Pt 1):1425-1431.
28. Riise GC, Kjellström C, Ryd W, Scherstén H, Nilsson F, Mårtensson G, Andersson BA: Inflammatory cells and activation markers in BAL during acute rejection and infection in lung transplant recipients: A prospective, longitudinal study. Eur Respir J (1997) 10(8):1742-1746.
29. Riise GC, Andersson BA, Kjellström C, Martensson G, Nilsson FN, Ryd W, Scherstén F: Persistent high BAL fluid granulocyte activation marker levels as early indicators of bronchiolitis obliterans after lung transplantation. Eur Respir J (1999) 14(5):1123-1130.
30. Baughman RP, Gunther KL, Rashkin MC, Keeton DA, Pattishal EN: Changes in the inflammatory response of the lung during acute respiratory distress syndrome: Prognostic indicators. Am J Respir Crit Care Med (1996) 154(1):76-81.
31. Geerts L, Jorens PG, Willems J, De Ley M, Slegers H: Natural inhibitors of neutrophil function in acute respiratory distress syndrome. Crit Care Med (2001) 29(10):1920-1924.
32. Stanescu D, Sanna A, Veriter C, Kostianev S, Calcagni PG, Fabbri LM, Maestrelli P: Airway obstruction, chronic expectoration, and rapid decline in FEV1 in smokers are associated with increased levels of sputum neutrophils. Thorax (1996) 51(3):267-271.
33. Fujimura M, Xiu Q, Tsujiura M, Tachibana H, Myou S, Matsuda T, Matsushima K: Role of leukotriene B4 in bronchial hyperresponsiveness induced by interleukin-8. Eur Respir J (1998) 11(2):306-311.
34. Matsumoto K, Aizawa H, Inoue H, Koto H, Nakano H, Hara N: Role of neutrophil elastase in ozone-induced airway responses in guinea-pigs. Eur Respir J (1999) 14(5):1088-1094.
35. Suzuki T, Wang W, Lin JT, Shirato K, Mitsuhashi H, Inoue H: Aerosolized human neutrophil elastase induces airway constriction and hyperresponsiveness with protection by intravenous pretreatment with half-length secretory leukoprotease inhibitor. Am J Respir Crit Care Med (1996) 153(4 Pt 1):1405-1411.
36. 3He diffusion. Proc Natl Acad Sci USA (2000) 97(21):11478-11481.
37. Zhu YK, Liu XD, Sköld CM, Umino T, Wang HJ, Spurzem JR, Kohyama T, Ertl RF, Rennard SI: Synergistic neutrophil elastase-cytokine interaction degrades collagen in three-dimensional culture. Am J Physiol Lung Cell Mol Physiol (2000) 281(4):L868-L878.
38. Sampson AP: The role of eosinophils and neutrophils in inflammation. Clin Exp Allergy (2000) 30(Suppl 1):22-27.
39. Schuster A, Ueki I, Nadel JA: Neutrophil elastase stimulates tracheal submucosal gland secretion that is inhibited by IC 200,355. Am J Physiol (1992) 262(1 Pt 1):L86-L91.
40. Nadel JA, Takeyama K, Agusti C: Role of neutrophil elastase in hypersecretion in asthma. Eur Respir J (1999) 13(1):190-196.
41. Culpitt SV, Maziak W, Loukidis S, Nightingale JA, Matthews JL, Barnes PJ: Effect of high dose inhaled steroid on cells, cytokines and proteases in induced sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1999) 160(5 Pt 1):1635-1639.
42. Adams JM, Hauser CJ, Livingston DH, Lavery RF, Fekete Z, Dietch EA: Early trauma polymorphonuclear neutrophil responses to chemokines are associated with development of sepsis, pneumonia and organ failure. J Trauma (2001) 51(3):452-456.
43. Ishizaka A, Watanabe M, Yamashita T, Ogawa Y, Koh H, Hasegawa N, Nakamura H, Asano K, Yamaguchi K, Kotani M, Kotani T et al: New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome. Crit Care Med (2001) 29(4):896-898.
44. Prikk K, Maisi P, Pirila E, Reintam MA, Salo T, Sorsa T, Sepper R: Airway obstruction correlates with collagenase-2 (MMP-8) expression and activation in bronchial asthma. Lab Invest (2002) 82(11):1535-1545.
45. Cataldo DD, Bettiol J, Noel A, Bartsch P, Foidart JM, Louis R: Matrix metalloproteinase-9, but not tissue inhibitor of matrix metalloproteinase-1, increases in the sputum from allergic asthmatic patients after allergen challenge. Chest (2002) 122(5):1553-1559.
46. Mattos W, Lim S, Russell R, Jatakanon A, Chung KF, Barnes PJ: Matrix metalloproteinase-9 expression in asthma: Effect of asthma severity, allergen challenge, and inhaled corticosteroids. Chest (2002) 122(5):1543-1552.
47. Lee YC, Lee HB, Rhee YK, Song CH: The involvement of matrix metalloproteinase-9 in airway inflammation of patients with acute asthma. Clin Exp Allergy (2001) 31(10):1623-1630.
48. Cataldo D, Munaut C, Noel A, Frankenne F, Bartsch P, Foidart JM, Louis R: MMP-2 and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease. Int Arch Allergy Immunol (2000) 123(3):259-267.
49. Cataldo DD, Tournoy KG, Vermaelen K, Munaut C, Foidart JM, Louis R, Noel A, Pauwels RA: Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation. Am J Pathol (2002) 161(2):491-498.
50. 2+/calmodulin-dependent protein kinase II inhibitors potentiate superoxide production in polymorphonuclear leukocytes. J Pharm Pharmacol (1999) 51(3):295-300.
51. Cortijo J, Villagrasa V, Pons R, Berto L, Marti-Cabrera M, Martinez-Losa M, Domenech T, Beleta J, Morcillo EJ: Bronchodilator and antiinflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes. Br J Pharmacol (1999) 127(7):1641-1651.
52. Sustiel AM, Joseph B, Rocklin RE, Borish L: Asthmatic patients have neutrophils that exhibit diminished responsiveness to adenosine. Am Rev Respir Dis (1989) 140(6):1556-1561.
53. Massion PP, Lindén A, Inoue H, Mathy M, Grattan KM, Nadel JA: Dimethyl sulfoxide decreases interleukin-8-mediated neutrophil recruitment in the airways. Am J Physiol (1996) 271(5 Pt 1):L838-L843.
54. Inoue H, Aizawa H, Nakano H, Matsumoto K, Kuwano K, Nadel JA, Hara N: Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med (2000) 161(1):249-256.
55. Stevens WH, Inman MD, Wattie J, O'Byrne PM: Allergen-induced oxygen radical release from bronchoalveolar lavage cells and airway hyperresponsiveness in dogs. Am J Respir Crit Care Med (1995) 151(5):1526-1531.
56. Takahashi T, Miura M, Katsumata U, Ichinose M, Kimura K, Inoue H, Takishima T, Shirato K: Involvement of superoxide in ozone-induced airway hyperresponsiveness in anesthetized cats. Am Rev Respir Dis (1993) 148(1):103-106.
57. Nakano H, Aizawa H, Matsumoto K, Fukuyama S, Inoue H, Hara N: Cyclooxygenase-2 participates in the late phase of airway hyperresponsiveness after ozone exposure in guinea pigs. Eur J Pharmacol (2000) 403(3):267-275.
58. Matsui S, Jones GL, Woolley MJ, Lane CG, Gontovnick LS, O'Byrne PM: The effect of antioxidants on ozone-induced airway hyperresponsiveness in dogs. Am Rev Respir Dis (1991) 144(6):1287-1290.
59. Hallahan AR, Armour CL, Black JL: Products of neutrophils and eosinophils increase the responsiveness of human isolated bronchial tissue. Eur Respir J (1990) 3(5):554-558.
60. Volcano M, Alves Rosa MF, Minnucci FS, Chernavsky AC, Isturiz MA: N-formyl-methionyl-leucyl-phenylalanine (fMLP) inhibits tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-stimulated human neutrophils. Clin Exp Immunol (1998) 113(1):39-47.
61. Page SM, Gleich GJ, Roebuck KA, Thomas LL: Stimulation of neutrophil interleukin-8 production by eosinophil granule major basic protein. Am J Respir Cell Mol Biol (1999) 21(2):230-237.
62. Keatings VM, Collins PD, Scott DM, Barnes PJ: Differences in interleukin-8 and tumor necrosis factor-α in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med (1996) 153(2):530-534.
63. Sibelius U, Hattar K, Hoffmann S, Mayer K, Grandel U, Schenkel A, Seeger W, Grimminger F: Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: Role of lipid mediator synthesis and sensitivity to interleukin-10. Crit Care Med (2002) 30(10):2306-2312.
64. Gambero A, Landucci EC, Toyama MH, Marangoni S, Giglio JR, Nader HB, Dietrich CP, De Nucci G, Antunes E: Human neutrophil migration in vitro induced by secretory phospholipases A2: A role for cell surface glycosaminoglycans. Biochem Pharmacol (2002) 63(1):65-72.
65. Fäldt J, Dahlgren C, Ridell M: Difference in neutrophil cytokine production induced by pathogenic and non-pathogenic mycobacteria. APMIS (2002) 110(9):593-600.
66. Kuhns DB, Nelson EL, Alvord WG, Gallin JI: Fibrinogen induces IL-8 synthesis in human neutrophils stimulated with formyl-methionyl-leucyl-phenylalanine or leukotriene B4. J Immunol (2001) 167(5):2869-2878.
67. Koller M, Wick M, Muhr G: Decreased leukotriene release from neutrophils after severe trauma: Role of immature cells. Inflammation (2001) 25(1):53-59.
68. Hattar K, Sibelius U, Bickenbach A, Csernock E, Seeger W, Grimminger F: Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis. J Leukocyte Biol (2001) 69(1):89-97.
69. 2 antagonist S-1452 in guinea-pigs. Clin Exp Allergy (1995) 25(1):51-59.
70. Hessel EM, Van Oosterhout AJ, Van Ark I, Van Esch B, Hofman G, Van Loveren H, Savelkoul HF, Nijkamp FP: Development of airway hyperresponsiveness is dependent on interferon-γ and independent of eosinophil infiltration. Am J Resp Cell Mol Biol (1997) 160(3):325-334.
71. Inoue H, Aizawa H, Nakano H, Matsumoto K, Kuwano K, Nadel JA, Hara N: Nitric oxie synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med (2000) 161(1):249-256.
72. Lindén A: Increased interleukin-8 release by β-adrenoceptor activation in human transformed bronchial epithelial cells. Br J Pharmacol (1996) 119(2):402-406.
73. Jorens PG, Richman-Eisenstat JB, Housset BP, Graf PD, Ueki IF, Olesch J, Nadel JA: Interleukin-8 induces neutrophil accumulation but not protease secretion in the canine trachea. Am J Physiol (1992) 263(6 Pt 1):L708-L713.
74. Amin K, Ludviksdottir D, Janson C, Nettelbladt O, Björnsson E, Roomans GM, Boman G, Seveus L, Venge P: Inflammation and structural changes in the airways of patients with atopic and non-atopic asthma. BHR Group. Am J Respir Crit Care Med (2000) 162(6):2295-2301.
75. Mazzarella G, Grella E, D'Auria D, Paciocco G, Perna F, Petillo O, Peluso G: Phenotypic features of alveolar monocytes/macrophages and IL-8 gene activation by IL-1 and TNF-α in asthmatic patients. Allergy (2000) 55(Suppl 61):36-41.
76. Marini M, Vittori E, Hollemborg J, Mattoli S: Expression of the potent inflammatory cytokines, granulocyte-macrophage-colony-stimulation factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma. J Allergy Clin Immunol (1992) 89(5):1001-1009.
77. Yousefi S, Hemmann S, Weber M, Hölzer C, Hartung K, Blaser K, Simon HU: IL-8 is expressed by human peripheral blood eosinophils. Evidence for increased secretion in asthma. J Immunol (1995) 154(10):5481-5490.
78. Hoshi H, Ohno I, Honma M, Tanno Y, Yamauchi K, Tamura G, Shirato K: IL-5, IL-8 and GM-CSF immunostaining of sputum cells in bronchial asthma and chronic bronchitis. Clin Exp Allergy (1995) 25(8):720-728.
79. Vanaudenaerde BM, Wuyts WA, Dupont LJ, Demetdts MG, Raemdonck DV, Verleden GM: The possible role of human airway smooth muscle cells (HASMC) in the pathogenesis of obliterative bronchiolitis after lung transplantation. Eur Respir J (2002) 20(S38):P2155.
80. Korn SH, Jerre A, Brattsand R: Effects of formoterol and budsonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells. Eur Respir J (2001) 17(6):1070-1077.
81. 2-agonists and corticosteroids on tumor necrosis factor-α-induced interleukin-8 release from cultured human airway smooth-muscle cells. Am J Respir Cell Mol Biol (2000) 23(1):79-85.
82. Tobler A, Meier R, Seitz M, Dewald B, Baggiolini M, Fey MF: Glucocorticoids downregulate gene expression of GM-CSF, NAP-1/IL-8, and IL-6, but not M-CSF in human fibroblasts. Blood (1992) 79(1):45-51.
83. Lukacs NW, Strieter RM, Elner V, Evanoff HL, Burdick MD, Kunkel SL: Production of chemokines, interleukin-8 and monocyte chemoattractant protein-1, during monocyte: Endothelial cell interactions. Blood (1995) 86(7):2767-2773.
84. Pizzichini MMM, Pizzichini E, Clelland L, Efthimiadis A, Pavord I, Dolovich J, Hargreave FE: Prednisone-dependent asthma: Inflammatory indices in induced sputum. Eur Respir J (1999) 13(1):15-21.
85. Gavett SH, Chen X, Finkelman F, Wills-Karp M: Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol (1994) 10(6):587-593.
86. Renzi PM, Yang JP, Diamantstein T, Martin JG: Effects of depletion of cells bearing the interleukin-2 receptor on immunoglobulin production and allergic airway responses in the rat. Am J Respir Crit Care Med (1996) 153(4 Pt 1):1214-1221.
87. Meshi B, Vitalis TZ, Ionescu D, Elliott WM, Liu C, Wang XD, Hayashi S, Hogg JC: Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response. Am J Respir Cell Mol Biol (2002) 26(1):52-57.
88. Mishima H, Hojo M, Watanabe A, Hamid QA, Martin JG: CD4+ T cells can induce airway hyperresponsiveness to allergen challenge in the brown Norway rat. Am J Respir Crit Care Med (1998) 158(6):1863-1870.
89. De Sanctis GT, Itoh A, Green FHY, Qin S, Kimura T, Grobholz JK, Martin TR, Maki T, Drazen JM: T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice. Nat Med (1997) 3(4):460-462.
90. Nakajima H, Iwamoto I, Tomoe S, Matsumura R, Tomioka H, Takatsu K, Yoshida S: CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am Rev Respir Dis (1992) 146(2):374-377.
91. Cieslewicz G, Tomkinson A, Adler A, Duez C, Schwarze J, Takeda K, Larson KA, Lee JJ, Irvin CG, Gelfand EW: The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration. J Clin Invest (1999) 104(3):301-308.
92. Tillie-Leblond I, Hammand H, Desurmont S, Pugin J, Wallaert B, Tonnel AB, Gosset P: CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus. Potential implication in eosinophil recruitment. Am J Respir Crit Care Med (2000) 162(2 Pt 1):586-592.
93. Leckie MJ, Ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, Mathur AK, Cowley HC, Chung KF, Djukanovic R, Hansel TT et al: Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet (2000) 356(9248):2144-2148.
94. Tomaki M, Zhao LL, Sjöstrand M, Lindén A, Ichinose M, Lötvall J: Comparison of effects of anti-IL-3, IL-5 and GM-CSF treatments on eosinophilopoiesis and airway eosinophilia induced by allergen. Pulm Pharmacol Ther (2002) 15(2):161-168.
95. Laitinen LA, Laitinen A, Haahtela T: Airway mucosal inflammation even in patients with newly diagnosed asthma, airway hyperresponsiveness, and the late asthmatic response. Am Rev Respir Dis (1993) 147(3):697-704.
96. Rutgers SR, Postma DS, ten Hacken NH, Kauffman HF, van Der Mark TW, Koeter GH, Timens W: Ongoing airway inflammation in patients with COPD who do not currently smoke. Thorax (2000) 55(1):12-18.
97. Turato G, Zuin R, Miniati M, Baraldo S, Rea F, Beghe B, Monti S, Formichi B, Boschetto P, Harari S, Papi A et al: Airway inflammation in severe chronic obstructive pulmonary disease: Relationship with lung function and radiologic emphysema. Am J Respir Crit Care Med (2002) 166(1):105-110.
98. Walker C, Kaegi MK, Braun P, Blaser K: Activated T cells and eosinophilia in bronchoalveolar lavage from subjects with asthma correlated with disease severity. J Allergy Clin Immunol (1991) 88(6):935-942.
99. Shin H, Benbernou N, Esnault S, Guenounou M: Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. Cytokine (1999) 11(4):257-266.
100. Aarvak T, Chabaud M, Miossec P, Natvig JB: IL-17 is produced by some proinflammatory Th1/Th0 cells but not Th2 cells. J Immunol (1999) 162(3):1246-1251.
101. Lenarczyk A, Helsloot J, Farmer K, Peters L, Sturgees A, Kirkham B: Antigen-induced IL-17 response in the peripheral blood mononuclear cells (PBMC) of healthy controls. Clin Exp Immunol (2000) 122(1):41-48.
102. Nakae S, Komiyama Y, Nambu A, Sudo K, Iwase M, Homma I, Sekikawa K, Asano M, Iwakura Y: Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity (2002) 17(3):375-387.
103. Miyamoto M, Prause O, Sjöstrand M, Laan M, Lötvall J, Lindén A: Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways. J Immunol (2003) 170(9):4665-4672. This study demonstrates that lung T-lymphocytes co-stimulated by airway macrophages are capable of releasing IL-17 and that endogenous IL-17 may play a central role in mediating endotoxin-induced neutrophil accumulation via MIP-2 and IL-6 in the lungs. The study also demonstrates the potentially beneficial effect of blocking IL-17 on the accumulation of lung neutrophils.
104. Molet S, Hamid Q, Davoine F, Nutku E, Taha R, Page N, Olivenstein R, Elias J, Chakir J: Interleukin-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol (2001) 108(3):430-438. This clinical study indicates that the expression of IL-17 in lungs is different in patient with asthma and in healthy individuals.
105. Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A: IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J Immunol (2003) 170(4):2106-2112.
106. Laan M, Palmberg L, Larsson K, Lindén A: Free, soluble interleukin-17 protein during severe inflammation in human airways. Eur Respir J (2002) 19(3):534-537. This study demonstrates that an inflammatory stimulus is capable of inducing a pronounced increase in free, soluble IL-17 protein in human lungs in vivo.
107. Yao Z, Spriggs MK, Derry JM, Strokbine L, Park LS, VandenBos T, Zappone JD, Painter SL, Armitage RJ: Molecular characterisation of the human interleukin (IL)-17 receptor. Cytokine (1997) 9(11):794-800. This early study provides important information on the IL-17 receptor.
108. Yao Z, Fanslow WC, Seldin MF, Rousseau AM, Painter SL, Comeau MR, Cohen JI, Spriggs MK: Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity (1995) 3(6):811-821. This early study provides information on the basic biology of the IL-17 molecule and its receptor.
109. Kehlen A, Thiele K, Riemann D, Langner J: Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis. Clin Exp Immunol (2002) 127(3):539-546.
110. Honorati MC, Meliconi R, Pulsatelli L, Cane S, Frizziero L, Facchini A: High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chrondrocytes from arthritis patients. Rheumatology (2001) 40(5):522-527.
111. Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, Maat C, Pin JJ, Garrone P, Garcia E, Saeland S, Blanchard D et al: T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med (1996) 183(6):2593-2603. Based upon in vitro experiments, this study provides early in vitro data indicating a potentially important generic role for IL-17 in innate immunity.
112. Laan M, Cui ZH, Hoshino H, Lötvall J, Sjöstrand M, Gruenert D, Skoogh BE, Lindén A: Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol (1999) 162(4):2347-2352. This study provides early in vivo data indicating a role for IL-17 as a mediator of neutrophil accumulation in lungs.
113. Laan M, Lötvall J, Chung KF, Lindén A: IL-17-induced cytokine release in human bronchial epithelial cells in vitro: Role of mitogen-activated protein (MAP) kinases. Br J Pharmacol (2001) 133(1):200-206.
114. Kawaguchi M, Kokubu F, Kuga H, Matsukura S, Hoshino H, Ieki K, Imai T, Adachi M, Huang SK: Modulation of bronchial epithelial cells by IL-17. J Allergy Clin Immunol (2001) 108(5):804-809.
115. Prause O, Laan M, Lötvall J, Lindén A: Pharmacological modulation of interleukin-17-induced GCP-2, GRO-α- and interleukin-8 release in human bronchial epithelial cells. Eur J Pharmacol (2003) 462(1-3):193-198.
116. Jones CE, Chan K: Interleukin-17 stimulates the expression of interleukin-8, growth-related oncogene-α, and granulocyte-colony-stimulating factor by human airway epithelial cells. Am J Respir Cell Mol Biol (2002) 26(6):748-753.
117. Awane M, Andres PG, Li DJ, Reinecker HC: NF-κB-inducing kinase is a common mediator of IL-17-, TNF-α-, and IL-1β-induced chemokine promoter activation in intestinal epithelial cells. J Immunol (1999) 162(9):5337-5344.
118. Mori N, Oishi K, Sar B, Mukaida N, Nagatake T, Matsushima K, Yamamoto N: Essential role of transcription factor nuclear factor-κ B in regulation of interleukin-8 gene expression by nitrite reductase from Pseudomonas aeruginosa in respiratory epithelial cells. Infect Immun (1999) 67(8):3872-3878.
119. Harper R, Wu K, Chang MM, Yoneda K, Pan R, Reddy SP, Wu R: Activation of nuclear factor-κB in airway epithelial cells by thioredoxin but not N-acetyl-cysteine and glutathione. Am J Respir Cell Mol Biol (2001) 25(2):178-185.
120. Chang MM, Harper R, Hyde DM, Wu R: A novel mechanism of retinoic acid-enhanced interleukin-8 gene expression in airway epithelium. Am J Respir Cell Mol Biol (2000) 22(4):502-510.
121. Kennedy T, Ghio AJ, Reed W, Samet J, Zagorski J, Quay J, Carter J, Dailey L, Hoidal JR, Devlin RB: Copper-dependent inflammation and nuclear factor-κB activation by particulate air pollution. Am J Respir Cell Mol Biol (1998) 19(3):366-378.
122. Mastronarde JG, Monick MM, Mukaida N, Matsushima K, Hunninghake GW: Activator protein-1 is the preferred transcription factor for cooperative interaction with nuclear factor-κB in respiratory syncytial virus-induced interleukin-8 gene expression in airway epithelium. J Infect Dis (1998) 177(5):1275-1281.
123. Laan M, Prause O, Miyamoto M, Sjöstrand M, Hytönen AM, Kaneko T, Lötvall J, Lindén A: A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-α. Eur Respir J (2003) 21(3):387-393. This study provides early in vivo data indicating synergism for IL-17 and TNFα in mediating neutrophil accumulation in lungs. It also suggests that IL-17 acts in part by causing de novo synthesis of a growth factor in bronchial epithelial cells.
124. Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R: Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem (2003) 278(19):17036-17043. This study provides in vitro data indicating that, among all interleukins, IL-17 is one of the few capable of directly inducing mucin gene expression in bronchial epithelial cells.
125. Hoshino H, Lötvall J, Skoogh BE, Lindén A: Neutrophil recruitment by IL-17 into rat airways in vivo. Role of tachykinins. Am J Respir Crit Care Med (1999) 159(5 Pt 1):1423-1428.
126. Hoshino H, Laan M, Sjöstrand M, Lötvall J, Skoogh BE, Lindén A: Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo. J Allergy Clin Immunol (2000) 105(1 Pt 1):143-149. This study provides early in vivo data suggesting that IL-17 is capable of indirectly increasing neutrophil activity in the lungs.
127. Ye P, Rodriguez FH, Kanaly S, Stocking KL, Schurr J, Schwarzenberger P, Oliver P, Huang W, Zhang P, Zhang J, Shellito JE et al: Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med (2001) 194(4):519-527. This study provides early in vivo data suggesting that endogenous IL-17 is crucial for host defense in the lungs.
128. Ye P, Garvey PB, Zhang P, Nelson S, Bagby G, Summer WR, Schwarzenberger P, Shellito JE, Kolls JK: Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol (2001) 25(3):335-340.
129. Larsson R, Rocksén D, Lilliehook B, Jonsson A, Bucht A: Dose-dependent activation by lymphocytes in endotoxin-induced airway inflammation. Infect Immun (2000) 68(12):6962-6969.
130. Hellings PW, Kasran A, Liu Z, Vandekerckhove P, Wuyts A, Overbergh L, Mathieu C, Ceuppens JL: Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am J Respir Cell Mol Biol (2003) 28(1):42-50. This study provides early in vivo data suggesting that endogenous IL-17 is involved in allergen-induced neutrophil accumulation in the lungs.
131. Barzyk A, Pierzcha W, Sozanska E: Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med (2003) 97(6):726-733. This study provides early in vivo data suggesting that the concentration of IL-17 is associated with BHR in human lungs.