Aerosolized human neutrophil elastase induces airway constriction and hyperresponsiveness with protection by intravenous pretreatment with half-length secretory leukoprotease inhibitor

American Journal of Respiratory and Critical Care Medicine

Volumn 153, Issue 4 PART I, 1996, Pages 1405-

  Suzuki, Toshiro ^b   Wang, Way ^b   Lin, Jing Tao ^b   Shirato, Kunio ^b   Mitsuhashi, Hiroaki ^b   Inoue, Hiroshi ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; LEUKOCYTE ELASTASE; RECOMBINANT HALF LENGTH SECRETORY LEUKOPROTEINASE INHIBITOR; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SEROTONIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

AIRWAY CONSTRICTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DOSE RESPONSE; GUINEA PIG; INFLAMMATION; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG LAVAGE; LUNG RESISTANCE; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTECTION;

AEROSOLS; ANIMALS; BRONCHI; BRONCHIAL HYPERREACTIVITY; BRONCHOCONSTRICTION; GUINEA PIGS; HUMANS; LEUKOCYTE ELASTASE; MALE; PANCREATIC ELASTASE; PROTEINASE INHIBITORY PROTEINS, SECRETORY; PROTEINS; RECOMBINANT PROTEINS; SERINE PROTEINASE INHIBITORS;

EID: 0029947548     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.153.4.8616573     Document Type: Article

References (21)

1. Umeki, S., Y. Niki, and R. Soejima. 1988. Elastase/antielastase systems in pulmonary diseases. Am. J. Med. Sci. 296:103-106.
2. Luisetti, M., P. D., Piccioni, A. M. Donnetta, A. Bulgheroni, and V. Peona. 1992. Protease-antiprotease imbalance: local evaluation with bronchoalveolar lavage. Respiration 59(Suppl.):24-27.
3. Amitani, R., R. Wilson, A. Rutman, R. Read, C. Ward, D. Burnett, R. A. Stockley, and P. J. Cole. 1991. Effect of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium. Am. J. Respir. Cell Mol. Biol. 4:26-32.
4. Sugahara, K., G. R. Cott, P. E. Parsons, R. J. Mason, R. A. Sandhaus, and P. M. Henson. 1986. Epithelial permeability produced by phagocytosing neutrophils in vitro. Am. Rev. Respir. Dis. 133:875-881.
5. Goldman, G., R. Welbourn, L. Kobzik, C. R. Valeri, D. Shepro, and H. B. Hechtman. 1992. Reactive oxygen species and elastase mediate lung permeability after acid aspiration. J. Appl. Physiol. 73:571-575.
6. Nadel, J. A. 1991. Role of mast cell and neutrophil proteases in airway secretion. Am. Rev. Respir. Dis. 144:548-551.
7. Fahy, J. V., A. Schuster, I. Ueki, H. A. Boushey, and J. A. Nadel. 1992. Mucus hypersecretion in bronchiectasis. The role of neutrophil elastases. Am. Rev. Respir. Dis. 146:1430-1433.
8. Snider, G. L., E. C. Lucey,T. G. Christensen, P. J. Stone, J. D. Galore, A. Catanese, and C. Franzblau. 1984. Emphysema and bronchial secretory cell metaplasia induced in hamsters by human neutrophil products. Am. Rev. Respir. Dis. 129:155-160.
9. Tegner, H., K. Ohlsson, N. G. Toremalm, and C. Mecklenburg. 1979. Effect of human leukocyte enzymes on tracheal mucosa and its mucociliary activity. Rhinology 17:199-206.
10. Smallman, L. A., S. L. Hill, and R. A. Stockley. 1984. Reduction of ciliary beat frequency in vitro by sputum from patients with bronchiectasis: a serine protease effect. Thorax 39:663-667.
11. Mooren, H. W. D., J. A. Kramps, C. Franken, C. J. L. M. Meijer, and J. A. Dijkman. 1983. Localization of a low-molecular-weight bronchial protease inhibitor in the peripheral human lung. Thorax 38:180-183.
12. Water, R. D. E., L. N. A. Willems, G. N. P. Muijen, C. Franken, J. A. M. Fransen, J. H. Dijkman, and J. A. Kramps. 1986. Ultra-structural localization of bronchial antileukoprotease in central and peripheral human airways by a gold-labeling tenchique using monoclonal antibodies. Am. Rev. Respir. Dis. 133:882-890.
13. Eisenberg, S. P., K. K. Hale, P. Heimdal, and R. C. Thompson. 1990. Location of the protease-inhibitory region of secretory leukocyte protease inhibitor. J. Biol. Chem. 265:7976-7981.
14. Kramps, J. A., C. Twisk, H. Appelhans, B. Meckelein, T. Nikiforov, and J. H. Dijkman. 1990. Proteinase inhibitory activities of antileukoprotease are represented by its second COOH-terminal domain. Biochem. Biophys. Acta 1038:178-185.
15. Stetler, G. L., C. Forsyth, T. Gleason, J. Wilson, and R. C. Thompson. 1989. Secretion of active, full- and half-length human secretory leukocyte proteinase inhibitor by Saccharomyces cerevisiae. Biotechnology 7:55-60.
16. Renesto, P., V. Balloy, T. Kamimura, K. Masuda, A. Imaizumi, and M. Chignard. 1992. Inhibition by recombinant truncated SLPI of cathepsin G activity. Consequence for the cooperation between neutrophils and platelets (abstract). Am. Rev. Respir. Dis. 145:A326.
17. Masuda, K., A. Imaizumi, T. Karaimura, K. Watanabe, T. Sugiyama, Y. Suzuki, and E. Ohtsuka. 1992. Expression of the C-terminal domain of secretory leukoprotease inhibitor in E. coli as a thrombincleavable fusion protein (abstract). Am. Rev. Respir. Dis. 145:A200.
18. Mead, J., and J. L. Whittenberger. 1953. Physical properties of human lungs measured during spontaneous respiration. J Appl. Physiol. 5: 779-796.
19. Hallahan, A. R., C. L. Armour, and J. L. Black. 1990. Products of neutrophils and eosinophils increase the responsiveness of human isolated bronchial tissue. Eur. Respir. J. 3:554-558.
20. Christensen, G. C., A. Lev, J. Ryan, M. Wang, S. Phillips, Y. T. Wachtfogel, F. Kueppers, and S. G. Kelsen. 1992. Rabbit trachealis responses to receptor-mediated agonists are diminished by elastase. Am. J. Respir. Cell Mol. Biol. 6:498-503.
21. Nagai, H., T. Tsuji, S. Shimazawa, S. Goto, K. Yoshitake, and A. Koda. 1984. Participation of collagenase and elastase in LPS-induced airway hyperresponsiveness in guinea pigs. Inflammation 15:317-330.