Ca2+/calmodulin-dependent protein kinase II inhibitors potentiate superoxide production in polymorphonuclear leukocytes

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 3, 1999, Pages 295-300

  Watanabe, Manabu ^a   Kaihatsu, Takayuki ^a   Miwa, Masao ^a   Maeda, Toshio ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; ENZYME INHIBITOR; FORMYLMETHIONYLLEUCYLPHENYLALANINE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; SUPEROXIDE; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; BENZYLAMINE DERIVATIVE; DRUG DERIVATIVE; PROTEIN KINASE (CALCIUM,CALMODULIN); SULFONAMIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; MALE; MOUSE; NEUTROPHIL; NONHUMAN; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; IN VITRO STUDY; METABOLISM;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; BENZYLAMINES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DRUG INTERACTIONS; ENZYME INHIBITORS; MALE; MICE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; SULFONAMIDES; SUPEROXIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032589281     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991772475     Document Type: Article

References (29)

1. Akimaru, K., Utsumi, T., Sato, E. F., Klostergaad, J., Inoue, M., Utsumi, K. (1992) Modulation of TNF-α-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors. Arch. Biochem. Biophys. 294: 271-278
2. Bokoch, G. M. (1995) Chemoattractant signaling and leukocyte activation. Blood 86: 1649-1660
3. 4 synthesis. J. Immunol. 140: 4315-4322
4. 2+/calmodulin-dependent protein kinase IV. J. Biol. Chem. 269: 15520-15527
5. 2+/calmodulin-dependent protein kinase II in cerebellar cells. J. Biol. Chem. 264: 21830-21836
6. Goldenring, J. R., Gonzalez, B., McGuire Jr, J. S., DeLorenzo, R. (1983) Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule-associated proteins. J. Biol. Chem. 258: 12632-12640
7. 2+/calmodulin-dependent protein kinases. Annu. Rev. Biochem. 61: 559-601
8. Henson, P. M., Johnston Jr, R. B. (1987) Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins. J. Clin. Invest. 79: 669-674
9. Hidaka, H., Sasaki, Y., Tanaka, T., Endo, T., Ohno, S., Fujii, Y., Nagata, T. (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc. Natl Acad. Sci. USA 78: 4354-4357
10. Hogg, J. C. (1987) Neutrophil kinetics and lung injury. Physiol. Rev. 67: 1249-1295
11. Ishida, A., Kameshita, I., Okuno, S., Kitani, T., Fujisawa, H. (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem. Biophys. Res. Commun. 212: 806-812
12. Klein, J. B., Scherzer, J. A., Harding, G., Jacobs, A. A., McLeish, R. (1995) TNF-α stimulates increased plasma membrane guanine nucleotide binding protein activity in polymorphonuclear leukocytes. J. Leukocyte Biol. 57: 500-506
13. Lehrer, R. I., Ganz, T., Selsted, M. E., Babior, B. M. (1988) Neutrophils and host defense. Ann. Intern. Med. 109: 127-142
14. Liang, L., Huang, C. K. (1995) Activation of multiple protein kinases induced by crosslinking of Fcy RII in human neutrophile. J. Leukocyte. Biol. 57: 326-331
15. 2+/calmodulin-dependent protein kinase II inhibitor KN-93. Biochem. Biophys. Res. Commun. 195: 608-615
16. ++/calmodulin-dependent protein kinase II inhibitors KN62 and KN93, and their inactive analogues KN04 and KN92, inhibit nicotinic activation of tyrosine hydroxylase in bovine chromaffin cells. Biochem. Biophys. Res. Commun. 221: 15-18
17. 2+/ calmodulin-dependent protein kinase II. Isozymic forms from rat forebrain and cerebellum. J. Biol. Chem. 260: 1696-1704
18. -. Anal. Biochem. 159: 363-369
19. Nathan, C. F. (1987) Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes. J. Clin. Invest. 80: 1550-1560
20. 2+/calmodulin-dependent protein kinases in insulin release from the rat pancreatic β cell. Biochem. Biophys. Res. Commun. 191: 255-261
21. 4, and platelet-activating factor. Dissociation from priming in human polymorphonuclear neutrophils. J. Irnmunol. 147: 3842-3847
22. 2+-mobilizing biosignaling. J. Biol. Chem. 259: 13863-13871
23. Perianin, A., Pedruzzi, E., Hakin, J. (1994) W-7, a calmodulin antagonist, primes the stimulation of human neutrophil respiratory burst by formyl peptides and platelet-activating factor. FEBS Lett. 342: 135-138
24. Roskoski Jr, R. (1983) Assays of protein kinase. Methods Enzymol. 99: 3-6
25. Schumann, M. A., Gardner, P., Raffin, T. A. (1993) Recombinant human tumor necrosis factor a induces calcium oscillation and calcium-activated chloride current in human neutrophils. The role of calcium/calmodulin-dependent protein kinase. J. Biol. Chem. 268: 2134-2140
26. 2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem. Biophys. Res. Commun. 181: 968-975
27. 2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 265: 4315-4320
28. 2+/CaM kinase). Cell Growth Diff. 6: 1063-1070
29. Utsumi, T., Klostergaard, J., Akimaru, K., Edashige, K., Sato, E. F., Utsumi, K. (1992) Modulation of TNF-α-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors. Arch. Biochem. Biophys. 294: 271-278