Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs: Possible role of interleukin-8

American Journal of Respiratory and Critical Care Medicine

Volumn 161, Issue 1, 2000, Pages 249-256

  Inoue, Hiromasa ^a,b   Aizawa, Hisamichi ^a,b   Nakano, Hiroyuki ^a,b   Matsumoto, Koichiro ^a,b   Kuwano, Kazuyoshi ^a,b   Nadel, Jay A ^a,b   Hara, Nobuyuki ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; AMINOGUANIDINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 8; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OZONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; BRONCHUS MUCOSA; CONTROLLED STUDY; CYTOKINE RELEASE; EXPOSURE; GUINEA PIG; HUMAN; HUMAN CELL; INFLAMMATION; LUNG LAVAGE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE;

EID: 0033984245     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.161.1.9804096     Document Type: Article

References (39)

1. 1. Hargreave, F. E., J. Dolovich, P. M. O'Byrne, E. H. Ramsdale, and E. E. Daniel. 1986. The origin of airway hyperresponsiveness. J. Allergy Clin. Immunol. 78:825-832.
2. 2. Fahy, J. V., K. W. Kim, J. Liu, and H. A. Boushey. 1995. Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J. Allergy Clin. Immunol. 95:843-852.
3. 3. Sur, S., T. B. Crotty, G. M. Kephart, B. A. Hyma, T. V. Colby, C. E. Reed, L. W. Hunt, and G. J. Gleich. 1993. Sudden-onset fatal asthma: a distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa? Am. Rev. Respir. Dis. 148:713-719.
4. 4. Bredt, D. S., P. M. Hwang, C. E. Glatt, C. Lowenstein, R. R. Reed, and S. H. Snyder. 1991. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351:714-718.
5. 5. Xie, Q. W., H. J. Cho, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee, A. Ding, T. Troso, and C. Nathan. 1992. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256:225-228.
6. 6. Gaston, B., J. M. Drazen, J. Loscalzo, and J. S. Stamler. 1994. The biology of nitrogen oxides in the airways. Am. J. Respir. Crit. Care Med. 149:538-551.
7. 7. Alving, K., E. Weitzberg, and J. M. Lundberg. 1993. Increased amount of nitric oxide in exhaled air of asthmatics. Eur. Respir. J. 6:1368-1370.
8. 8. Massaro, A. F., B. Gaston, D. Kita, C. Fanta, J. S. Stamler, and J. M. Drazen. 1995. Expired nitric oxide levels during treatment of acute asthma. Am. J. Respir. Crit. Care Med. 152:800-803.
9. 9. Bult, H., G. E. Boeckxstaens, P. A. Pelckmans, F. H. Jordaens, Y. M. Van Maercke, and A. G. Herman. 1990. Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature 345:346-347.
10. 10. DeForge, L. E., A. M. Preston, E. Takeuchi, J. Kenney, L. A. Boxer, and D. G. Remick. 1993. Regulation of interleukin 8 gene expression by oxidant stress. J. Biol. Chem. 268:25568-25576.
11. 11. Villarete, L. H., and D. G. Remick. 1995. Nitric oxide regulation of IL-8 expression in human endothelial cells. Biochem. Biophys. Res. Commun. 211:671-676.
12. 12. Bayon, Y., A. Alonso, and M. Sanchez Crespo. 1997. Stimulation of Fc gamma receptors in rat peritoneal macrophages induces the expression of nitric oxide synthase and chemokines by mechanisms showing different sensitivities to antioxidants and nitric oxide donors. J. Immunol. 159:887-894.
13. 13. Stevens, W. H., P. D. Conlon, and P. M. O'Byrne. 1995. Ozone-induced oxygen radical release from bronchoalveolar lavage cells and airway hyperresponsiveness in dogs. J. Physiol. 486:257-265.
14. 14. Pendino, K. J., C. R. Gardner, R. L. Shuler, J. D. Laskin, S. K. Durham, D. S. Barton, S. Tsuyoshi Ohnishi, T. Ohnishi, and D. L. Laskin. 1996. Inhibition of ozone-induced nitric oxide synthase expression in the lung by endotoxin. Am. J. Respir. Cell Mol Biol. 14:516-525.
15. 15. Devlin, R. B., K. P. McKinnon, T. Noah, S. Becker, and H. S. Koren. 1994. Ozone-induced release of cytokines and fibronectin by alveolar macrophages and airway epithelial cells. Am. J. Physiol. 266:L612-619.
16. 16. Aris, R. M., D. Christian, P. Q. Hearne, K. Kerr, W. E. Finkbeiner, and J. R. Balmes. 1993. Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy. Am. Rev. Respir. Dis. 148:1363-1372.
17. 17. Xiu, Q., M. Fujimura, M. Nomura, M. Saito, T. Matsuda, N. Akao, K. Kondo, and K. Matsushima. 1995. Bronchial hyperresponsiveness and airway neutrophil accumulation induced by interleukin-8 and the effect of the thromboxane A2 antagonist S-1452 in guinea-pigs. Clin. Exp. Allergy 25:51-59.
18. 18. Inoue, H., P. P. Massion, I. F. Ueki, K. M. Grattan, M. Hara, A. F. Dohrman, B. Chan, J. A. Lausier, J. A. Golden, and J. A. Nadel. 1994. Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium, in gland ducts, and in recruited neutrophils. Am. J. Respir. Cell Mol. Biol. 11:651-663.
19. 19. Asano, K., C. B. Chee, B. Gaston, C. M. Lilly, C. Gerard, J. M. Drazen, and J. S. Stamler. 1994. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 91:10089-10093.
20. 20. Roum, J. H., and C. Murlas. 1984. Ozone-induced changes in muscarinic bronchial reactivity by different testing methods. J. Appl. Physiol. 57: 1783-1789.
21. 21. Misko, T. P., W. M. Moore, T. P. Kasten, G. A. Nickols, J. A. Corbett, R. G. Tilton, M. L. McDaniel, J. R. Williamson, and M. G. Currie. 1993. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol. 233:119-125.
22. 22. Robbins, R. A., D. R. Springall, J. B. Warren, O. J. Kwon, L. D. Buttery, A. J. Wilson, I. M. Adcock, V. Riveros-Moreno, S. Moncada, J. Polak, and P. J. Barnes. 1994. Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation. Biochem. Biophys. Res. Commun. 198:835-843.
23. 23. Cross, A. H., T. P. Misko, R. F. Lin, W. F. Hickey, J. L. Trotter, and R. G. Tilton. 1994. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J. Clin. Invest. 93:2684-2690.
24. 24. Koto, H., H. Aizawa, S. Takata, H. Inoue, and N. Hara. 1995. An important role of tachykinins in ozone-induced airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 151:1763-1769.
25. 25. Matsumoto, K., H. Aizawa, H. Inoue, M. Shigyo, S. Takata, and N. Hara. 1996. Thromboxane causes airway hyperresponsiveness after cigarette smoke-induced neurogenic inflammation. J. Appl. Phvsiol. 81:2358-2364.
26. 26. Schmidt, H. H., T. D. Warner, M. Nakane, U. Forstermann, and F. Murad. 1992. Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages. Mol. Pharmacol. 41:615-624.
27. 27. Yoshimura, T., and D. G. Johnson. 1993. cDNA cloning and expression of guinea pig neutrophil attractant protein-1 (NAP-1): NAP-1 is highly conserved in guinea pig. J. Immunol. 151:6225-6236.
28. 28. Sadeghi-Hashjin, G., G. Folkerts, P. A. Henricks, A. K. Verheyen, H. J. van der Linde, I. van Ark, A. Coene, and F. P. Nijkamp. 1996. Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo. Am. J. Respir. Crit. Care Med. 153:1697-1701.
29. 29. Kharitonov, S. A., B. J. O'Connor, D. J. Evans, and P. J. Barnes. 1995. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am. J. Respir. Crit. Care Med. 151:1894-1899.
30. 30. Belenky, S. N., R. A. Robbins, S. I. Rennard, G. L. Gossman, K. J. Nelson, and I. Rubinstein. 1993. Inhibitors of nitric oxide synthase attenuate human neutrophil chemotaxis in vitro. J. Lab. Clin. Med. 122:388-394.
31. 31. Beauvais, F., L. Michel, and L. Dubertret. 1995. Exogenous nitric oxide elicits chemotaxis of neutrophils in vitro. J. Cell Physiol. 165:610-614.
32. 2' -dependent inducible nitric oxide synthase from guinea-pig lung. Biochem. J. 333:795-799.
33. 33. Knowles, R. G., M. Merrett, M. Salter, and S. Moncada. 1990. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem. J. 270:833-836.
34. 34. Noiri, E., T. Peresleni, F. Miller, and M. S. Goligorsky. 1996. In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. J. Clin. Invest. 97:2377-2383.
35. 35. Gross, S. S., D. J. Stuehr, K. Aisaka, E. A. Jaffe, R. Levi, and O. W. Griffith. 1990. Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. Biochem. Biophys. Res. Commun. 170:96-103.
36. 36. Mukaida, N., S. Okamoto, Y. Ishikawa, and K. Matsushima. 1994. Molecular mechanism of interleukin-8 gene expression. J. Leukocyte Biol. 56:554-558.
37. 37. Lander, H. M., P. K. Sehajpal, and A. Novogrodsky. 1993. Nitric oxide signaling: a possible role for G proteins. J. Immunol 151:7182-7187.
38. 38. Stevens, W. H., C. Vanderheyden, J. Wattie, C. G. Lane, W. Smith, and P. M. O'Byrne. 1995. Effect of a leukotriene B4 receptor antagonist SC-53228 on ozone-induced airway hyperresponsiveness and inflammation in dogs. Am. J. Respir. Crit. Care Med. 152:1443-1448.
39. 39. Haddad, E. B., M. Salmon, H. Koto, P. J. Barnes, I. Adcock, and K. F. Chung. 1996. Ozone induction of cytokine-induced neutrophil chemo-attractant (CINC) and nuclear factor-kappa b in rat lung: inhibition by corticosteroids. FEBS Lett. 379:265-268.