Coupling of Changes in Cerebral Blood Flow with Neural Activity: What Must Initially Dip Must Come Back Up

Journal of Cerebral Blood Flow and Metabolism

Volumn 24, Issue 1, 2004, Pages 1-6

  Ances, Beau M ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Activation flow coupling; Cerebral blood flow and metabolism; Deoxyhemoglobin; Initial dip

Indexed keywords

DEOXYHEMOGLOBIN; NITRIC OXIDE;

BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN METABOLISM; BRAIN MITOCHONDRION; BRAIN OXYGEN CONSUMPTION; DEOXYGENATION; HUMAN; NERVE CELL; NEUROIMAGING; PRIORITY JOURNAL; REVIEW;

EID: 0346102880     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000103920.96801.12     Document Type: Review

References (66)

1. Ances BM, Buerk DG, Greenberg JH, Detre JA (2001) Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats. Neurosci Lett 306:106-110
2. Atwell D, Iadecola C (2002) The neural basis of functional brain imaging signals. Trends Neurosci 25:621-625
3. Atwell D, Laughlin SB (2001) An energy budget for signaling in the gray matter of the brain. J Cereb Blood Flow Metab 21:1133-1145
4. Aubert A, Costalat R (2002) A model of the coupling between brain electrical activity, metabolism, and hemodynamics: application to the interpretation of functional neuroimaging. Neuroimage 17:1162-1181
5. Baumane L, Dzintare M, Zvejniece L, Meirena D, Lauberte L, Sile V, Kalvinsh I, Sjakste N (2002) Increased synthesis of nitric oxide in rat brain cortex due to halogenated volatile anesthetics confirmed by EPR spectroscopy. Acta Anesthesiol Scand 46:378-382
6. Buerk DG, Ances BM, Greenberg JH, Detre JA (2003) Temporal dynamics of brain tissue nitric oxide during functional forepaw stimulation in rats. Neuroimage 18:1-9
7. Buxton RB (2001) The elusive initial dip. Neuroimage 13:953-958
8. Clarke DD, Sokoloff L (1994) Circulation and energy metabolism of the brain. In: Basic neurochemistry: molecular, cellular, and medical aspects, fifth edition (Siegel GJ, Agranoff BW, Albers W, Molinoff BM, eds), New York: Raven Press, pp 645-680
9. Cohen ER, Ugurbil K, Kim SG (2002) Effect of basal conditions on the magnitude and dynamics of the blood oxygenation level-dependent fMRI response. J Cereb Blood Flow Metab 22:1042-1053
10. Duong TQ, Kim, DS, Urgurbil K (2000) Spatiotemporal dynamics of the BOLD fMRI signals: toward mapping submillimeter cortical columns using the early negative response. Magn Reson Med 44:231-342
11. Ernst T, Hennig J (1994) Observation of a fast response in functional MR. Magn Reson Med 32:146-149
12. Frahm J, Merbolt KD, Hanicke W, Kleinschmidt A, Boeker H (1994) Brain or vein-oxygenation or flow? On signal physiology in functional MRI of human brain activation. NMR Biomedicine 7:45-53
13. Fujita H, Kuwabara H, Reutens, DC, Gjedde A (1999) Oxygen consumption of cerebral cortex fails to increase during continued vibrotactile stimulation. J Cereb Blood Flow Metab 19:266-271
14. Galley HF, LeCras AE, Logan SD, Webster NR (2001) Differential nitric oxide synthase activity, cofactor availability and cGMP accumulation in the central nervous system during anesthesia. Br J Anaesth 86:388-394
15. Gjedde A (1997) The relation between brain function and cerebral blood flow and metabolism. In: Cerebrovascular disease (Batjer HH, ed) Philadelphia: Lippincott-Raven, pp 23-40
16. Gotoh J, Kuang TY, Nakao Y, Cohen DM, Melzer P, Itoh Y, Pak H, Pettigrew K, Sokoloff L (2001) Regional differences in mechanisms of cerebral circulatory response to neuronal activation. Am J Physiol Heart Circ Physiol 280:H821-H829
17. Grinvald A, Slovin H, Vanzetta I (2000) Non-invasive visualization of cortical columns by fMRI. Nat Neurosci 3:105-107
18. Hall DA, Gonclaves MS, Smith S, Jezzard P, Haggard, MP, Kornack J (2002) A method for determining venous contribution to BOLD contrast sensory activation. Magn Reson Imaging 20:695-706
19. Harel N, Lee SP, Nagaoka T, Kim DS, Kim SG (2002) Origin of negative blood oxygenation level-dependent fMRI signals. J Cereb Blood Flow Metab 22:908-917
20. Hu X, Le TH, Ugurbil K (1997) Evaluation of the early response in fMRI in individual subjects using short stimulus duration. Magn Reson Med 37:877-884
21. Hyder F, Chase, JR, Behar KL, Mason GF, Siddeek M, Rothman DL, Shulman RG (1996) Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H[13C]NMR. Proc Natl Acad Sci U S A 93:7612-7617
22. Hyder F, Kennan RP, Kida I, Mason GF, Behar KL, Rothman D (2000) Dependence of oxygen delivery on blood flow in rat brain: a 7 tesla nuclear magnetic resonance study. J Cereb Blood Flow Metab 20:485-498
23. Hyder F, Schulman RG, Rothman DL (1998) A model for regulation of cerebral oxygen delivery. J Appl Physiol 85:554-564
24. Ido Y, Kilo C, Williamson JR (1997) Cytosolic NADH/NAD+, free radicals, and vascular dysfunction in early diabetes mellitus. Diabetologia 40 (Suppl 2):115-117
25. Janz C, Schmitt C, Speck O, Hennig J (2000) Comparison of the hemodynamic response to different visual stimuli in single-event and block stimulation fMRI experiments. J Magn Reson Imaging 12:708-714
26. Janz C, Speck O, Hennig J (1997) Time-resolved measurements of brain activation after a short visual stimulus: new results on the physiological mechanisms of the cortical response. NMR Biomed 10:222-229
27. Jezzard P, Rauschecker JP, Malonek D (1997) An in vivo model for functional MRI in cat visual cortex. Magn Reson Med 38:699-705
28. Jones M, Berwick J, Johnston D, Mayhew J (2001) Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex. Neuroimage 13:1002-1015
29. Kanno I, Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels. personal communication.
30. Kemna LJ, Posse S (2001) Effect of respiratory CO2 changes on the temporal dynamics of the hemodynamic response in functional MR imaging. NeuroImage 14:642-649
31. Kim SG, Duong TQ (2002) Mapping Cortical columnar structures using fMRI. Physiol Behav 77:641-644
32. Kim DS, Duong TQ, Kim SG (2000) High-resolution mapping of isoorientation columns by fMRI [see comments]. Nat Neurosci 3:164-169
33. Kohl, M, Lindauer U, Royl G, Kuhl M, Gold L, Villringer A, Dirnagl U (2000) Physical model for the spectroscopic analysis of cortical intrinsic optical signals. Phys Med Biol 45:3749-3764
34. Lindauer U, Megow D, Matsuda H, Dirnagl U (1999) Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in the rat somatosenory cortex. Am J Physiol 277:H799-H811
35. Lindauer U, Royl G, Leithner C, Kuhl M, Gold L, Gethmann J, Kohl-Bareis M, Villringer A, Dirnagl U (2001) No evidence for early decrease in blood oxygenation in rat whisker cortex in response to functional activation. Neuroimage 13:988-1001
36. Logothetis NK, Guggenberger H, Peled S, Pauls J (1999) Functional imaging of the monkey brain. Nat Neurosci 2:555-562
37. Logothetis NK, Pauls J, Augath M, Trinath T, Oeltermann A (2001) Neurophysiological investigation of the basis of the fMRI signal. Nature 412:150-157
38. Malonek D, Dirnagl U, Lindauer U, Yamada K, Kanno I, Grinvald A (1997) Vascular imprints of neuronal activity: relationships between the dynamics of cortical blood flow oxygenation, and volume changes following sensory stimulation. Proc Natl Acad Sci U S A 94:14826-14831
39. Malonek D, Grinvald A (1996) Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping. Science 272:551-554
40. Mandeville JB, Marota JJ, Ayata C, Moskowitz MA, Weisskoff RM, Rosen BR (1999) MRI measurement of the temporal evolution of relative CMRO(2) during rat forepaw stimulation. Magn Reson Med 42:944-951
41. Marota JJ, Ayata C, Moskowitz MA, Weisskoff RM, Rosen BR, Mandeville JB (1999) Investigation of the early response to rat forepaw stimulation. Magn Reson Med 41:247-252
42. Mayhew J, Johnston D, Berwick J, Jones M, Coffey P, Zheng Y (2000) Spectroscopic analysis of neural activity in brain: increased oxygen consumption following activation of barrel cortex. Neuroimage 12:664-675
43. Mayhew J, Johnston D, Martindale J, Jones M, Berwick J, Zheng Y (2001) Increased oxygen consumption following activation of brain: theoretical footnotes using spectroscopic data from barrel cortex. Neuroimage 13:975-987
44. Menon RS, Ogawa S, Hu X, Strupp JP, Anderson P, Ugurbil K (1995) BOLD based functional MRI at 4 Tesla includes a capillary bed contribution: echo-planar imaging correlates with previous optical imaging using intrinsic signals. Magn Reson Med 33:453-459
45. Mintun MA, Lundstrom BN, Snyder AZ, Vlassenko AG, Shulman GL, Raichle ME (2001) Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data. Proc Natl Acad Sci U S A 98:6859-6864
46. Nakao Y, Itoh Y, Kuang TY, Cook M, Jehle J, Sokoloff L (2001) Effects of anesthesia on functional activation of cerebral blood flow and metabolism. Proc Natl Acad Sci U S A 98:7593-7598
47. Nemoto M, Nomura Y, Sato C, Tamura M, Houkin K, Koyanagi I, Abe H (1999) Analysis of optical signals evoked by peripheral nerve stimulation in rat somatosensory cortex: dynamic changes in hemoglobin concentration and oxygenation. J Cereb Blood Flow Metab 19:246-259
48. Obrig H, Villringer A (2003) Beyond the visible-imaging the human brain with light. J Cereb Blood Flow Metab 23:1-18
49. Pouratian N, Sheth SA, Martin NA, Toga AW (2003) Shedding light on brain mapping: advances in human optical imaging. Trends Neurosci 5:277-282
50. Powers WJ, Hirsch IB, Creyer PE (1996) Effect of stepped hypoglycemia on regional cerebral blood flow response to physiological activation. Am J Physiol 27:H554-H559
51. Roc AC, Wetmore GS, Wang JJ, Kasner SE, Liebskind DS, Detre JA (2004) Altered coupling between regional cerebral blood flow and regional brain activation in patients with cerebrovascular disease. Stroke In Press
52. Rother J, Knab R, Hamzei F, Fiehler J, Reichenbach JR, Buchel C, Weiller C (2002) Negative dip in BOLD fMRI is cause by blood flow-oxygen consumption uncoupling in humans. NeuroImage 15:98-102
53. Shtoyerman E, Arieli A, Slovin H, Vanzetta I, Grinvald A (2000) Long-term optical imaging and spectroscopy reveal mechanisms underlying the intrinsic signal and stability of cortical maps in V1 of behaving monkeys. J Neurosci 20:8111-8121
54. Silva AC, Lee SP, Iadecola C, Kim SG (2000) Early temporal characteristics of cerebral blood flow and deoxyhemoglobin changes during somatosensory stimulation. J Cereb Blood Flow Metab 20:201-206
55. Thomas DD, Liu X, Kantrow SP, Lancaster JR Jr (2001) The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2. Proc Natl Acad Sci U S A 98:355-360
56. Thompson JK, Peterson MR, Freeman RD (2003) Single-neuron activity and tissue oxygenation in the cerebral cortex. Science 299:1070-1072
57. Turner R (2001) BOLD localization: the implications of vascular architecture. NeuroImage 13 (Suppl):1011
58. Vafaee MS, Meyer E, Marrett S, Paus T, Evans AC, Gjedde A (1999) Frequency-dependent changes in cerebral metabolic rate of oxygen during activation of human visual cortex. J Cereb Blood Flow Metab 19:272-277
59. Vanzetta I, Grinvald A (1999) Increased cortical oxidative metabolism due to sensory stimulation: implications for functional brain imaging. Science 286:1555-1558
60. Villringer A, Dirnagl U (1995) Coupling of brain activity and cerebral blood flow: basis of functional neuroimaging. Cereb Brain Metab Rev 7:240-276
61. White RP, Hindley C, Bloomfield PM, Cunningham VJ, Vallance P, Brooks DJ, Markus HS (1999) The effect of the nitric oxide synthase inhibitor L-NMMA on basal CBF and vasoneuronal coupling in man: a PET study. J Cereb Blood Flow Metab 19:673-678
62. Wilson DF (1992) Oxygen dependent quenching of phosphorescence: a perspective. Adv Exp Med Biol 317:195-201
63. Woolsey TA, Rovainen CM, Cox SB, Henegar MH, Liang GE, Liu D, Moskalenko YE, Sui J, Wei L (1996) Neuronal units linked to microvascular modules in cerebral cortex: response elements for imaging the brain. Cereb Cortex 6:647-660
64. Yacoub E, Hu X (1999) Detection of the early negative response in fMRI at 1.5 Tesla. Magn Reson Med 41:1088-1092
65. Yacoub E, Hu X (2001) Detection of the early decrease in fMRI signal in the motor area. Magn Reson Med 45:184-190
66. Yacoub E, Le TH, Ugurbil K, Hu X (1999) Further evaluation of the initial negative response in functional magnetic resonance imaging. Magn Reson Med 41:436-441