Regional differences in mechanisms of cerebral circulatory response to neuronal activation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 280, Issue 2 49-2, 2001, Pages

  Gotoh, Jun ^a   Kuang, Tang Yong ^a   Nakao, Yasuaki ^a   Cohen, David M ^a   Melzer, Peter ^a   Itoh, Yoshiaki ^a   Pak, Hazel ^a   Pettigrew, Karen ^a   Sokoloff, Louis ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

7 nitroindazole; Adenosine; Caffeine; NG nitro L arginine; Nitric oxide

Indexed keywords

7 NITROINDAZOLE; ADENOSINE; ADENOSINE RECEPTOR BLOCKING AGENT; CAFFEINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN NERVE CELL; CELL ACTIVATION; CONTROLLED STUDY; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SOMATOSENSORY CORTEX; SPINAL CORD STIMULATION; THALAMUS VENTRAL NUCLEUS; TRIGEMINAL NUCLEUS;

EID: 0035017060     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.280.2.h821     Document Type: Article

References (37)

1. Adachi K, Takahashi S, Melzer P, Campos KL, Nelson T, Kennedy C, and Sokoloff L. Increases in local cerebral blood flow associated with somatosensory activation are not mediated by NO. Am J Physiol Heart Circ Physiol 267: H2155-H2162, 1994.
2. Ayata C, Ma J, Meng W, Huang P, and Moskowitz MA. L-NA-sensitive rCBF augmentation during vibrissal stimulation in type III nitric oxide synthase mutant mice. J Cereb Blood Flow Metab 16: 539-541, 1996.
3. Bryan RM, Hollinger BR, Keefer KA, and Rage RB. Regional cerebral and neural lobe blood flow during insulin-induced hypoglycemia in unanesthetized rats. J Cereb Blood Flow Metab 7: 96-102, 1987.
4. Cholet N, Bonvento G, and Seylaz J. Effect of neuronal NO synthase inhibition on the cerebral vasodilatory response to somatosensory stimulation. Brain Res 708: 197-200, 1996.
5. Cholet N, Seylaz J, Lacombe P, and Bonvento G. Local uncoupling of the cerebrovascular and metabolic responses to somatosensory stimulation after neuronal nitric oxide synthase inhibition. J Cereb Blood Flow Metab 17: 1191-1201, 1997.
6. Dirnagl U, Lindauer U, and Villinger A. Role of nitric oxide in the coupling of cerebral blood flow to neural activation in rats. Neurosci Lett 149: 43-46, 1993.
7. Dirnagl U, Niwa K, Lindauer U, and Villinger A. Coupling of cerebral blood flow to neural activation: role of adenosine and nitric oxide. Am J Physiol Heart Circ Physiol 267: H296-H301, 1994.
8. Ginsberg MD, Dietrich WD, and Busto R. Coupled forebrain increases of local cerebral glucose utilization and blood flow during physiologic stimulation of a somatosensory pathway in the rat: demonstration by double label autoradiography. Neurology 37: 11-19, 1987.
9. Hirsh K. Central nervous system pharmacology of the dietary methylxanthines. In: The Methylxanthine Beverages and Foods: Chemistry, Consumption, and Health Effects, edited by Spiller GA. New York: Liss, 1984, p. 235-301.
10. Horinaka N, Artz N, Jehle J, Takahashi S, Kennedy C, and Sokoloff L. Examination of potential mechanisms in the enhancement of cerebral blood flow by hypoglycemia and pharmacological doses of deoxyglucose. J Cereb Blood Flow Metab 17: 54-63, 1997.
11. Horinaka N, Kuang TY, Pak H, Wang R, Jehle J, Kennedy C, and Sokoloff L. Blockade of cerebral blood flow response to insulin-induced hypoglycemia by caffeine and glibenclamide in conscious rats. J Cereb Blood Flow Metab 17: 1309-1318, 1997.
12. Irikura K, Maynard KI, and Moskowitz MA. Importance of nitric oxide synthase inhibition to the attenuated vascular responses induced by topical L-nitroarginine during vibrissal stimulation. J Cereb Blood Flow Metab 14: 45-48, 1994.
13. Kadekaro M, Crane AM, and Sokoloff L. Differential effects of electrical stimulation of sciatic nerve on metabolic activity in spinal cord and dorsal root ganglion in the rat. Proc Natl Acad Sci USA 82: 6010-6013, 1985.
14. Kety SS and Schmidt CF. The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J Clin Invest 27: 484-492, 1948.
15. Ko KR, Ngai AC, and Winn HR. Role of adenosine in regulation of cerebral blood flow in sensory cortex. Am J Physiol Heart Circ Physiol 259: H1703-H1708, 1990.
16. Lindauer U, Megow D, Matsuda H, and Dirnagl U. Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in rat somatosensory cortex. Am J Physiol Heart Circ Physiol 277: H799-H811, 1999.
17. Lindauer U, Megow D, Schultze J, Weber JR, and Dirnagl U. Nitric oxide synthase inhibition does not affect somatosensory evoked potentials in the rat. Neurosci Lett 216: 207-210, 1996.
18. Lou HC, Edvinsson L, MacKenzie ET. The concept of coupling blood flow to brain function: revision required? Ann Neurol 22: 287-297, 1987.
19. Ma J, Ayata C, Huang PL, Fishman MC, and Moskowitz MA. Regional cerebral blood flow response to vibrissal stimulation in mice lacking type I NOS gene expression. Am J Physiol Heart Circ Physiol 270: H1085-H1090, 1996.
20. MacKenzie GM, Rose S, PA, Bland-Ward Moore PK, Jenner P, Marsden CD. Time course of inhibition of brain nitric oxide synthase by 7-nitroindazole. Neuroreport 5: 1993-1996, 1994.
21. Mata M, Fink DJ, Gainer H, Smith CB, Davidsen L, Savaki H, Schwartz WJ, and Sokoloff L. Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. J Neurochem 34: 213-215, 1980.
22. Ngai AC, Meno JR, Jolley MA, and Winn HR. Suppression of somatosensory evoked potentials by nitric oxide synthase inhibition in rats; methodological differences. Neurosci Lett 245: 171-174, 1998.
23. Ngai AC, Meno JR, and Winn HR. L-NNA suppresses cerebrovascular response and evoked potentials during somatosensory stimulation. Am J Physiol Heart Circ Physiol 269: H1803-H1810, 1995.
24. Niwa K, Araki E, Morham SG, Elizabeth Ross M, and Iadecola C. Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex. J Neurosci 20: 763-770, 2000.
25. Phillis JW. Adenosine in the control of the cerebral circulation. Cerebrovasc Brain Metab Rev 1: 26-54, 1989.
26. Phyllis JW and DeLong RE. The role of adenosine in cerebral vascular regulation during reductions in perfusion pressure. J Pharm Pharmacol 38: 460-462, 1986.
27. Roy CS and Sherrington CS. On the regulation of the blood supply of the brain. J Physiol (Lond) 11: 85-108, 1890.
28. Rubio R, Berne RM, and Winn HR. Production, metabolism and possible functions of adenosine in brain tissue in situ. In: Cerebral Vascular Smooth Muscle and Its Control, edited by Purves MJ and Elliott K. Amsterdam: Elsevier, 1978, p. 355-378.
29. 14C]antipyrine. Am J Physiol Heart Circ Physiol 234: H59-H66, 1978.
30. Sokoloff L. Local cerebral energy metabolism: its relationships to local functional activity and blood flow. In: Cerebral Vascular Smooth Muscle and Its Control, edited by Purves MJ and Elliott K. Amsterdam: Elsevier, 1978, p. 171-197.
31. Sokoloff L. Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose. J Cereb Blood Flow Metab 1: 7-36, 1981.
32. Sokoloff L. Energetics of functional activation in neural tissues. Neurochem Res 24: 321-329, 1999.
33. Sokoloff L, Kennedy C, Adachi K, Wang F, Takahashi S, and Melzer P. Effects of inhibitors of nitric oxide synthase on resting local cerebral blood flow and on the changes induced by hypercapnia or local functional activity. In: Pharmacology of Cerebral Ischemia 1992, edited by Krieglstein J and Oberpichler H. Stuttgart, Germany: Wissenschaftliche, 1992, p. 371-382.
34. 14C] deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28: 897-916, 1977.
35. Takahashi S, Cook M, Jehle J, Kennedy C, and Sokoloff L. Lack of effects of inhibition of nitric oxide synthesis on local cerebral glucose utilization in the rat brain. J Neurochem 65: 414-419, 1995.
36. Wang Q, Kjaer T, Jorgensen MB, Paulson OB, and Lassen NA. Nitric oxide does not act as a mediator coupling cerebral blood flow to neural activity following somatosensory stimuli in rats. Neurol Res 15: 33-36, 1993.
37. Winn H, Rubio R, and Berne RM. The role of adenosine in the regulation of cerebral blood flow. J Cereb Blood Flow Metab 1: 239-244, 1981.