Origin of negative blood oxygenation level-dependent fMRI signals

Journal of Cerebral Blood Flow and Metabolism

Volumn 22, Issue 8, 2002, Pages 908-917

  Harel, Noam ^a   Lee, Sang Pil ^a   Nagaoka, Tsukasa ^a   Kim, Dae Shik ^a   Kim, Seong Gi ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Brain mapping; Cerebral blood flow; Cerebral blood volume; Contrast agents; Iron oxides; MION; Oxygen consumption rate

Indexed keywords

CONTRAST MEDIUM;

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ARTICLE; BLOOD OXYGENATION; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN CIRCULATION; BRAIN MAPPING; CAT; CONTROLLED STUDY; CORRELATION ANALYSIS; FREQUENCY MODULATION; MODULATION; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SUPRASYLVIAN GYRUS; TECHNIQUE; VISUAL CORTEX; VISUAL STIMULATION;

EID: 0036323287     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200208000-00002     Document Type: Article

References (54)

1. Functional MRI cerebral activation and deactivation during finger movement
2. Processing strategies for time-course data sets in functional MRI of the human brain
3. Visual and auditory association areas of the cat's posterior ectosylvian gyrus: Thalamic afferents
4. Functional MRI evidence for a role of frontal and inferior temporal cortex in amodal components of priming
5. Factors involved in the physiological regulation of the cerebral circulation
6. Dynamics of blood flow and oxygenation changes during brain activation: The balloon model
7. Effect of basal conditions on the magnitude and dynamics of the BOLD fMRI response
8. Processing of form and motion in area 21a of cat visual cortex
9. Areas PMLS and 21a of cat visual cortex: Two functionally distinct areas
10. Spatio-temporal dynamics of the BOLD fMRI signals: Toward mapping columnar structures using the early negative response
11. Localized cerebral blood flow response at submillimeter columnar resolution
12. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): Use of a cluster-size threshold
13. MRI of functional deactivation: Temporal and spatial characteristics of oxygenation-sensitive responses in human visual cortex
14. The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time
15. FLASH imaging. Rapid NMR imaging using low flip angle pulses
16. Observation of positive and negative BOLD signals in visual cortex
17. Blood capillary distribution correlates with hemodynamic-based functional imaging in cerebral cortex
18. Spikes versus BOLD: What does neuroimaging tell us about neuronal activity?
19. Magnetic resonance imaging (MRI) detection of the murine brain response to light: Temporal differentiation and negative functional MRI changes
20. Task-specific deactivation patterns in functional magnetic resonance imaging
21. Spatial frequency maps in cat visual cortex
22. Changes in human regional cerebral blood flow and cerebral blood volume during visual stimulation measured by positron emission tomography
23. 2 changes on the temporal dynamics of the hemodynamic response in functional mr imaging
24. Physiological basis for BOLD MR signal changes due to neuronal stimulation: Separation of blood volume and magnetic susceptibility effects
25. Potential pitfalls of functional MRI using conventional gradient-recalled echo techniques
26. High-resolution mapping of iso-orientation columns by fMRI
27. Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: Implications for BOLD fMRI
28. Neurophysiological investigation of the basis of the fMRI signal
29. Vascular imprints of neuronal activity: Relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation
30. Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation
31. Effect of pentobarbital on visual processing in man
32. Modification of activity-dependent increases of cerebral blood flow by excitatory synaptic activity and spikes in rat cerebellar cortex
33. Neuronal responsiveness in area 21a of the cat
34. Spatial and temporal frequency selectivity of cells in area 21a of the cat
35. Spatial and temporal contrast sensitivity of neurons in areas 17 and 18 of the cat's visual cortex
36. Brain magnetic resonance imaging with contrast dependent on blood oxygenation
37. High-resolution mapping of discrete representational areas in rat somatosensory cortex using blood volume-dependent functional MRI
38. The retinotopic organization of lateral suprasylvian visual areas in the cat
39. Behind the scenes of functional brain imaging: A historical and physiological perspective
40. A default mode of brain function
41. Thalamic deactivation during early implicit sequence learning: A functional MRI study
42. A direct quantitative relationship between the functional properties of human and macaque V5
43. Spatio-temporal frequency domains and their relation to cytochrome oxidase staining in cat visual cortex
44. Sustained negative BOLD response in the human brain investigated at ultra high field
45. Common blood flow changes across visual tasks. Part II: Decreases in cerebral cortex
46. Attentional suppression of activity in the human visual cortex
47. Stimulate: A GUI-based fMRI analysis software package
48. Spatial and temporal frequency tuning and contrast sensitivity of single neurons in area 21a of the cat
49. High-resolution functional magnetic resonance imaging of the rat brain: Mapping changes in cerebral blood volume using iron oxide contrast media
50. Increased cortical oxidative metabolism due to sensory stimulation: Implications for functional brain imaging
51. Responses of cerebral arterioles to increased venous pressure
52. Response characteristics of the cells of cortical area 21a of the cat with special reference to orientation specificity
53. Neuronal units linked to microvascular modules in cerebral cortex: Response elements for imaging the brain
54. Spatial and temporal selectivity in the suprasylvian visual cortex of the cat