Temporal dynamics of brain tissue nitric oxide during functional forepaw stimulation in rats

NeuroImage

Volumn 18, Issue 1, 2003, Pages 1-9

  Buerk, Donald G ^a   Ances, Beau M ^a   Greenberg, Joel H ^a   Detre, John A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cerebral blood flow; Functional activation; Laser Doppler flowmetry; Nitric oxide; Nitric oxide microelectrode; Nitric oxide synthase

Indexed keywords

NITRIC OXIDE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOWMETRY; BRAIN TISSUE; CONTROLLED STUDY; ELECTROCHEMISTRY; ELECTROSTIMULATION; FOREFOOT; LASER DOPPLER FLOWMETRY; MALE; MICROELECTRODE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RAT; SOMATOSENSORY CORTEX;

EID: 0037227492     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1006/nimg.2002.1314     Document Type: Article

References (52)

1. Adachi, T., Takahashi, S., Melzer, P., Campos, K. L., Nelson, T., Kennedy, C., and Sokoloff, L. 1994. Increases in local cerebral blood flow associated with somatosensory activation are not mediated by NO. Am. J. Physiol. 267: H2155-H2162.
2. Akgoren, N., Fabricius, M., and Lauritzen, M. 1994. Importance of nitric oxide for local increases of blood flow in rat cerebellar cortex during electrical stimulation. Proc. Natl. Acad. Sci. USA 91: 5903-5907.
3. Ances, B. M., Buerk, D. G., Greenberg, J. H., and Detre, J. A. 2001a. Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats. Neurosci. Lett. 306: 106-110.
4. Ances, B. M., Greenberg, J. H., and Detre, J. A. 1999. Laser Doppler imaging of activation-flow coupling in the rat somatosensory cortex. NeuroImage 10: 716-723.
5. Ances, B. M., Greenberg, J. H., and Detre, J. A. 2000a. Effects of variations in interstimulus interval on activation flow coupling response and somatosensory evoked potentials with forepaw stimulation in the rat. J. Cereb. Blood Flow Metab. 20: 290-297.
6. Ances, B. M., Greenberg, J. H., and Detre, J. A. 2000b. Acute carotid occlusion alters the activation flow coupling response to forepaw stimulation in a rat model. Stroke 31: 955-960.
7. Ances, B. M., Greenberg, J. H., and Detre, J. A. 2001b. The effects of graded hypercapnia on the activation flow coupling response due to forepaw stimulation in alpha-chloralose anesthetized rats. Brain Res. 911: 82-88.
8. 2 during functional activation using oxygen phosphorescence. J. Cereb. Blood Flow Metab. 21: 511-516.
9. Ances, B. M., Zarahn, E., Greenberg, J. H., and Detre, J. A. 2000c. The coupling of neural activation to blood flow in the somatosensory cortex of rats is time-intensity separable, but not linear. J. Cereb. Blood Flow Metab. 20: 921-930.
10. Bohlen, H. G. 1998. Mechanism of increased vessel wall nitric oxide concentrations during intestinal absorption. Am. J. Physiol. Heart Circ. Physiol. 275: H542-H550.
11. Bonvento, G., Sibson, N., and Pellerin, L. 2002. Does glutamate image your thoughts? Trends Neurosci. 25: 359-364.
12. Buchanan, J. E., and Phillis, J. W. 1993. The role of nitric oxide in the regulation of cerebral blood flow. Brain Res. 610: 248-255.
13. Buerk, D. G. 2001. Can we model NO biotransport? A survey of mathematical models for a simple diatomic molecule with surprisingly complex biological activities. Annu. Rev. Biomed. Eng. 3: 109-143.
14. Buerk, D. G., and Riva, C. E. 1998. Vasomotion and spontaneous low frequency oscillations in blood flow and nitric oxide in cat optic nerve head. Microvasc. Res. 55: 103-112.
15. Buerk, D. G., Riva, C. E., and Cranstoun, S. D. 1996. Nitric oxide has a vasodilatory role in cat optic nerve head during flicker stimuli. Microvasc. Res. 52: 13-26.
16. Buxton, R. B. 2001. The elusive initial dip. NeuroImage 13: 953-958.
17. Cholet, N., Seylaz, J., Lacombe, P., and Bonvento, G. 1997. Local uncoupling of the cerebrovascular and metabolic responses to somatosensory stimulation after neuronal nitric oxide synthase inhibition. J. Cereb. Blood Flow Metab. 17: 1191-1201.
18. Detre, J. A., Ances, B. M., Takahashi, K., and Greenberg, J. H. 1998. Signal averaged laser Doppler measurements of activation-flow coupling in the rat forepaw somatosensory cortex. Brain Res. 726: 91-98.
19. Dirnagl, U., Lindauer, U., and Villringer, A. 1993. Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats. Neurosci. Lett. 149: 43-46.
20. Fox, P. T., and Raichle, M. E. 1986. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc. Natl. Acad. Sci. USA 83: 1140-1144.
21. Fox, P. T., Raichle, M. E., Mintun, M. A., and Dence, C. 1988. Nonoxidative glucose consumption during focal physiologic neural activation. Science 241: 462-464.
22. Fukamura, D., Gohongi, T., Kadambi, A., Ang, J., Yun, C.-O., Buerk, D. G., Huang, P. L., and Jain, R. K. 2001. Predominant role of endothelial nitric oxide synthase in VEGF-induced angiogenesis and vascular permeability. Proc. Natl. Acad. Sci. USA 98: 2604-2609.
23. Greenberg, J. H., Sohn, N. W., and Hand, P. J. 1999. Nitric oxide and the cerebral-blood-flow response to somatosensory activation following deafferentation. Exp. Brain Res. 129: 541-550.
24. Gotoh, J., Kuang, T.-Y., Nakao, Y., Cohen, D. M., Melzer, P., Itoh, Y., Pak, H., Pettigrew, K., and Sokoloff, L. 2001. Regional differences in mechanisms of cerebral circulatory response to neuronal activation. Am. J. Physiol. 280: H821-H829.
25. Harder, D. R., Zhang, C., and Gebremedhin, D. 2002. Astrocytes function in matching blood flow to metabolic activity. News Physiol. Sci. 16: 27-31.
26. Hetz, L., and Fillenz, M. 1999. Does the "mystery of the extra glucose" during CNS activation reflect glutamate synthesis? Neurochem. Int. 34: 71-75.
27. Hyder, F., Kida, I, Behar, K. L., Kennan, R. P., Maciejewski, P. K., and Rothman, D. L. 2001. Quantitative functional imaging of the brain: Toward mapping neuronal activity by BOLD fMRI. NMR Biomed. 14: 413-431.
28. Iadecola, C., Li, J., Ebner, T. J., and Xu, X. 1995. Nitric oxide contributes to functional hyperemia in cerebellar cortex. Am. J. Physiol. 268: R1153-1162.
29. Iadecola, C., Li, J., Xu, S., and Yang, G. 1996. Neural mechanisms of blood flow regulation during synaptic activity in cerebellar cortex. J. Neurophysiol. 75: 940-950.
30. Iadecola, C., Pelligrino, D. A., Moskowitz, M. A., and Lassen, N. A. 1994. Nitric oxide synthase inhibition and cerebrovascular regulation. J. Cereb. Blood Flow Metab. 14: 175-192.
31. Jones, M., Berwick, J., Johnston, D., and Mayhew, J. 2001. Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: The relationship between blood flow, oxygenation, and volume in rodent barrel cortex. NeuroImage 13: 1002-1015.
32. Jones, M., Berwick, J., and Mayhew, J. 2002. Changes in blood flow, oxygenation, and volume follows extended stimulation of rodent barrel cortex. NeuroImage 15: 474-487.
33. Li, J., and Iadecola, C. 1994. Nitric oxide and adenosine mediate vasodilation during functional activation in cerebellar cortex. Neuropharmacology 33: 1453-1461.
34. Lindauer, U., Megow, D., Matsuda, H., and Dirnagl, U. 1999. Nitric oxide: A modulator, but not a mediator of neurovascular coupling in rat somatosensory cortex. Am. J. Physiol. 277: H799-H811.
35. Lindauer, U., Royl, G., Leitner, C., Kuhl, M., Gold, L., Gethmann, J., Kohl-Bareis, M., Villringer, A., and Dirnagl, U. 2001. No evidence for early decrease in blood oxygenation in rat whisker cortex in response to functional activation. NeuroImage 13: 988-1001.
36. Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., and Oeltermann, A. 2001. Neurophysiological investigation of the basis of the fMRI signal. Nature 412: 150-157.
37. Madsen, P. L., Cruz, N. F., Sokoloff, L., and Dienel, G. A. 1999. Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: Excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue. J. Cereb. Blood Flow. Metab. 19: 393-400.
38. Madsen, P. L., Linde, R., Hasselbalch, S. A. G., Paulson, O. B., and Lassen, N. A. 1998. Activation-induced resetting of cerebral oxygen and glucose uptake in the rat. J. Cereb. Blood Flow Metab. 18: 742-748.
39. Mayhew, J., Johnston, D., Martindale, J., Jones, M., Berwick, J., and Zheng, Y. 2001. Increased oxygen consumption following activation of brain: Theoretical footnotes using spectroscopic data from barrel cortex. NeuroImage 13: 975-987.
40. Ngai, A. C., Meno, J. R., and Winn, H. R. 1995. L-NNA suppresses cerebrovascular response and evoked potentials during somatosensory stimulation in rats. Am. J. Physiol. 269: H1083-H1810.
41. Nielsen, A. N., and Lauritzen, M. 2001. Coupling and uncoupling of activity-dependent increases of neuronal activity and blood flow in rat somatosensory cortex. J. Physiol. 533: 773-785.
42. Raichle, M. E. 1998. Behind the scenes of functional brain imaging: A historical and physiological perspective. Proc. Natl. Acad. Sci. USA 95: 765-772.
43. Riva, C. E., and Buerk, D. G. 1998. Dynamic coupling of blood flow to function and metabolism in the optic nerve head. Neuro-Ophthalmology 20: 45-54.
44. Roy, C. S., and Sherrington, C. S. 1890. On the regulation of the blood-supply of the brain. J. Physiol. 11: 85-108.
45. Schmetterer, L., and Polak, K. 2001. Role of nitric oxide in the control of ocular blood flow. Prog. Retinal Eye Res. 20: 823-847.
46. Schmitz, B., Bottinger, B. W., and Hossmann, K. A. 1996. Brief hypercapnia enhances somatosensory activation of blood flow in rat. J. Cereb. Blood Flow Metab. 16: 1307-1311.
47. Schulman, R. G., Rothman, D. L., and Hyder, F. 2001. Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging. Proc. Natl. Acad. Sci. USA 98: 3245-3250.
48. Sibson, N. R., Dhankhar, A., Mason, G. F., Rothman, D. L., Behar, K. L., and Shulman, R. G. 1998. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc. Natl. Acad. Sci. USA 95: 316-321.
49. Thom, S. R., Bhopale, V., Fisher, D., Manevich, Y., Huang, P. L., and Buerk, D. G. 2002. Stimulation of nitric oxide synthase in cerebral cortex due to elevated partial pressures of oxygen: An oxidative stress response. J. Neurobiol. 51: 85-100.
50. Vanzetta, I., and Grinvald, A. 1999. Increased cortical oxidative metabolism due to sensory stimulation: Implications for functional brain imaging. Science 286: 1555-1558.
51. Vanzetta, I., and Grinvald, A. 2001. Evidence and lack of evidence for the initial dip in the anesthetized rat: Implications for human functional brain imaging. NeuroImage 13: 959-967.
52. Wang, Q., Kjaer, T., Jorgensen, M. B., Paulson, O. B., Lassen, N. A., Diemer, N. H., and Lou, H. C. 1993. Nitric oxide does not act as a mediator coupling cerebral blood flow to neural activity following somatosensory stimuli in rats. Neurol. Res. 15: 33-36.