Single-neuron activity and tissue oxygenation in the cerebral cortex

Science

Volumn 299, Issue 5609, 2003, Pages 1070-1073

  Thompson, Jeffrey K ^a   Peterson, Matthew R ^a   Freeman, Ralph D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; HEMODYNAMICS; MAGNETIC RESONANCE IMAGING; METABOLISM; OXYGEN; TISSUE;

CEREBRAL CORTEX;

NEUROLOGY;

OXYGEN;

BRAIN; NEUROLOGY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; HEMODYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN BLOOD LEVEL; PREDICTION; PRIORITY JOURNAL; REGULATORY MECHANISM; SCALE UP; TISSUE OXYGENATION; VISUAL CORTEX;

ACTION POTENTIALS; ANIMALS; CATS; CEREBROVASCULAR CIRCULATION; DOMINANCE, OCULAR; ELECTRODES, IMPLANTED; HEMOGLOBINS; KINETICS; MAGNETIC RESONANCE IMAGING; MICROELECTRODES; NEURONS; OXYGEN; OXYGEN CONSUMPTION; PHOTIC STIMULATION; VISUAL CORTEX;

ANIMALIA;

EID: 0037436170     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079220     Document Type: Article

References (24)

1. P. A. Bandettini, E. C. Wong, R. S. Hinks, R. S. Tikofsky, J. S. Hyde, Magn. Reson. Med. 25, 390 (1992).
2. K. K. Kwong et al., Proc. Natl. Acad. Sci. U.S.A. 89, 5675 (1992).
3. S. Ogawa et al., Proc. Natl. Acad. Sci. U.S.A. 89, 5951 (1992).
4. N. K. Logothetis, J. Pauls, M. Augath, T. Trinath, A. Oettermann, Nature 412, 150 (2001).
5. E. A. Disbrow, D. A. Slutsky, T. P. Roberts, L. A. Krubitzer, Proc. Natl. Acad. Sci. U.S.A. 97, 9718 (2000).
6. D. S. Kim, T. Q. Duong, S. G. Kim, Nature Neurosci. 3, 164 (2000).
7. A. F. Cannestra et al., Cereb. Cortex 11, 773 (2001).
8. D. Malonek, A. Grinvaid, Science 272, 551 (1996).
9. A. Grinvald, H. Slovin, I. Vanzetta, Nature Neurosci. 3, 105 (2000).
10. N. K. Logothetis, H. Guggenberger, S. Peled, J. Pauls, Nature Neurosci. 2, 555 (1999).
11. E. Yacoub et al., NMR Biomed. 14, 408 (2001).
12. I. Vanzetta, A. Grinvald, Science 286, 1555 (1999).
13. V. B. Mountcastle, Brain 120, 701 (1997).
14. J. J. Marota et al., Magn. Reson. Med. 41, 247 (1999).
15. A. C. Silva, S. P. Lee, C. Iadecola, S. G. Kim, J. Cereb. Blood Flow. Metab. 20, 201 (2000).
16. J. Mayhew et al., Neuroimage 10, 304 (1999).
17. U. Lindauer et al., Neuroimage 13, 988 (2001).
18. R. B. Buxton, E. C. Wong, L. R. Frank, Magn. Reson. Med. 39, 855 (1998).
19. Y. Zheng et al., Neuroimage 16, 617 (2002).
20. I. Fatt, Polarographic Oxygen Sensors (CRC, Cleveland, OH, 1976), pp. 197-218.
21. Materials and methods are available as supporting material on Science Online.
22. H. Kanaiwa, H. Kuchiwaki, S. Inao, K. Sugita, Surg. Neurol. 44, 172 (1995).
23. The high-resolution measurements from our combined sensor were localized within the activated areas of the cortex with minimal overlap into non-activated areas. As a result, we observed a stronger initial dip with an expanded time course. A similar effect is observed in high-resolution BOLD fMRI measurements (6). The time required for oxygen in the vasculature to diffuse into tissue may also contribute to the longer initial dip.
24. Supported by research and CORE grants from the National Eye Institute (EY01175 and EY03176, respectively) as well as an NIH training grant (T32 EY 07043-24). We thank Unisense A/S for cooperation in development of the combined sensor, M. D'Esposito for helpful comments during preparation of the manuscript, S. Bierer and B. Li for helpful discussions and data collection, and L. Altamirano for help with sensor calibration.