Differential nitric oxide synthase activity, cofactor availability and cGMP accumulation in the central nervous system during anaesthesia

British Journal of Anaesthesia

Volumn 86, Issue 3, 2001, Pages 388-394

  Galley, H F ^a   Le Cras, A E ^a   Logan, S D ^a   Webster, N R ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Brain, cerebral cortex; Brain, hippocampus; Pharmacology, nitric oxide; Rat

Indexed keywords

ANESTHETIC AGENT; ARGININE; CARBON 14; CITRULLINE; CYCLIC GMP; DIAZEPAM; HALOTHANE; ISOFLURANE; KETAMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PENTOBARBITAL; TETRAHYDROBIOPTERIN; XENON;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN CORTEX; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; FEMALE; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; ISOTOPE LABELING; MICROWAVE RADIATION; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; RAT; SCINTILLATION COUNTING; SPINAL CORD;

EID: 0035102769     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/86.3.388     Document Type: Article

References (27)

1. Nitric oxide in a nutshell: Genetics, physiology and pathology
2. Maturation alters cerebral NOS kinetics in the spontaneously hypertensive rat
3. Nitric oxide, cyclic guanosine monophosphate and the anesthetic state
4. Brain nitric oxide synthase activity is decreased by intravenous anesthetics
5. Selective anesthetic inhibition of brain nitric oxide synthase
6. Nox-level in the rat hippocampus and striatum has no direct relation with anaesthetic condition induced by ketamine
7. Changes in brain levels of cyclic nucleotides and γ-aminobutyric acid in barbiturate dependence and withdrawal
8. Effect of enflurane on cerebellar cGMP and on motor activity in the mouse
9. Nitric oxide synthase assays
10. Analysis of reduced forms of biopterin in biological tissues and fluids
11. In vivo production of nitric oxide correlates with NMDA-induced cerebral hyperemia in newborn sheep
12. A modified citrulline assay of NOS activity in rat brain homogenates does not detect direct effects of halothane on the kinetics of NOS activity
13. How does xenon produce anaesthesia?
14. Anaesthetic agents decrease the activity of nitric oxide synthase from human polymorphonuclear leucocytes
15. Inhalational anesthetic effects on rat cerebellar nitric oxide and cyclic guanosine monophosphate production
16. Inhibitory effects of anesthetics on cyclic guanosine monophosphate (cGMP) accumulation in rat cerebellar slices
17. Isoflurane enhances glutamatergic agonist-stimulated nitric oxide synthesis in cultured neurons
18. Cerebellar cGMP varies with motor function and respiratory exchange
19. Possible obligatory functions of cyclic nucleotides in hypercapnia-induced cerebral vasodilation in adult rats
20. Depression of some drug-induced in vivo changes of cerebellar guanosine 3′,5′-monophosphate by control of motor and respiratory responses
21. Cyclic AMP and cyclic GMP response to stress in brain and pituitary: Stress elevates pituitary cyclic AMP
22. Ketamine inhibits glutamate, N-methyl-d-aspartate- and quisqualate-stimulated cGMP production in cultured cerebral neurons
23. Molecular interactions of anaesthetics with biological membranes
24. Localization of GTP cyclohydrolase in monoaminergic but not nitric oxide producing cells
25. Regulation of cerebellar nitric oxide production in response to prolonged in vivo hypoxia
26. The effect of midazolam and propofol on interleukin-8 from human polymorphonuclear leukocytes