Caspase activity is required for commitment to Fas-mediated apoptosis

EMBO Journal

Volumn 16, Issue 13, 1997, Pages 3805-3812

  Longthorne, Vanessa L ^a   Williams, Gwyn T ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

Apoptosis; Caspase; CD95 (Fas APO 1); FLICE; Interleukin 1 converting enzyme; MACH

Indexed keywords

CYSTEINE PROTEINASE; FAS ANTIGEN; INTERLEUKIN 1BETA CONVERTING ENZYME;

APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL DEATH; CONTROLLED STUDY; ETIOLOGY; HUMAN; HUMAN CELL; MAMMAL CELL; PRIORITY JOURNAL; RECOGNITION; T LYMPHOCYTE;

AMINO ACID CHLOROMETHYL KETONES; ANTIGENS, CD95; APOPTOSIS; CELL DIVISION; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HUMANS; JURKAT CELLS; POLY(ADP-RIBOSE) POLYMERASES; SERPINS; T-LYMPHOCYTES; TUMOR CELLS, CULTURED; VIRAL PROTEINS;

EID: 0031009716     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.13.3805     Document Type: Article

References (50)

1. Adachi, M., Watanabe-Fukunaga, R. and Nagata, S. (1993) Aberrant transcription caused by the insertion of an early transposable element in the intron of the Fas antigen gene of lpr mice. Proc. Natl Acad. Sci. USA, 90, 1756-1760.
2. Alnemri, E.S., Livingston, D.J., Nicholson, D.W., Salvesen, G., Thornberry, N.A., Wong, W.W. and Yuan, J. (1996) Human ICE/CED-3 protease nomenclature. Cell, 87, 171.
3. Boldin, M.P, Goncharov, T.M., Goltsev, Y.V. and Wallach, D. (1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/Apo-1- and TNF receptor-induced cell death. Cell, 85, 803-815.
4. Brunner, T. et al. (1995) Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature, 373, 441-444.
5. Chow, S.C., Weis, M., Kass, E.N., Holmström, T.H., Eriksson, J.E. and Orrenius, S. (1995) Involvement of multiple proteases during Fasmediated apoptosis in T lymphocytes. FEBS Lett., 364, 134-138.
6. Dhein, J., Walczak, H., Bäumler, C., Debatin, K.-M. and Krammer, P.H. (1995) Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature, 373, 438-441.
7. Ellis, R.E. and Horvitz, H.R. (1986) Genetic control of programmed cell death in the nematode Caenorhabditis elegans. Cell, 44, 817-829.
8. Enari, M., Hug, H. and Nagata, S. (1995) Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature, 375, 78-81.
9. Enari, M., Talanian, R.V., Wong, W.W. and Nagata, S. (1996) Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature, 380, 723-726.
10. Fearnhead, H.O., MacFarlane, M., Dinsdale, D. and Cohen, G.M. (1995) DNA degradation and proteolysis in thymocyte apoptosis. Toxicol. Lett., 82/83, 135-141.
11. Friesen, C., Herr, I., Krammer, P.H. and Debatin, K.-M. (1996) Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis. Nature Med., 2, 574-577.
12. Gagliardini, V., Fernandez, P.A., Lee, R.K.K., Drexler, H.C.A., Rotello, R.J., Fishman, M.C. and Yuan, J. (1994) Prevention of vertebrate neuronal death by the crmA gene. Science, 263, 826-828.
13. Hale, A.J., Smith, C.A., Sutherland, L.C., Stoneman, V.E.A., Longthorne, V.L., Culhane, A.C. and Williams, G.T. (1996) Apoptosis: molecular regulation of cell death. Eur. J. Biochem., 236, 1-26.
14. Jacobson, M.D., Weil, M. and Raff, M.C. (1996) Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death. J. Cell Biol., 133, 1041-1051.
15. Ju, S.-T., Panka, D.J., Cul, H., Ettinger, R., El-Khatib, M., Sherr, D.H., Stanger, B.Z. and Marshak-Rothstein, A. (1995) Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature, 373, 444-448.
16. Kaufmann, S.H., Desnoyers, S., Ottaviano, Y., Davidson, N.E. and Poirier, G.G. (1993) Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res., 53, 3976-3985.
17. Kuida, K., Lippke, J.A, Ku,G., Harding, M.W., Livingston, D.J., Su, M.S.S. and Flavell, R.A. (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science, 267, 2000-2003.
18. Kuida, K., Zheng, T.S., Na, S., Kuan, C., Yang, D., Karasuyama, H., Rakic, P. and Flavell, R.A. (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature, 384, 368-372.
19. Lazebnik, Y.A., Kaufmann, S.H., Desnoyers, S., Poirier, G.G. and Earnshaw, W.C. (1994) Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature, 371, 346-347.
20. Li, P. et al. (1995) Mice deficient in IL-1β converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell, 80, 401-411.
21. Los, M. et al. (1995) Requirement of an ICE/CED-3 protease for Fas/ APO-1-mediated apoptosis. Nature, 375, 81-83.
22. MacGregor, G.R. (1992) Optimisation of electroporation using reporter genes. In Chang, D.C., Chassy, B.C., Saunders, J.A. and Sowers, A.E. (eds). Guide to Electroporation and Electrofusion. Academic Press Inc., San Diego, CA, p. 465.
23. Martin, S.J. and Green, D.R. (1995) Protease activation during apoptosis: death by a thousand cuts? Cell, 82, 349-352.
24. Mashima, T., Naito, M. Kataoka, S., Kawai, H. and Tsuro, T. (1995) Aspartate-based inhibitor of interleukin-1β converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukaemia U937 cells. Biochem. Biophys. Res. Commun., 209, 907-915.
25. McCarthy, N.J., Whyte, M.K.B., Gilbert, C.S. and Evan, G.I. (1997) Inhibition of CED-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage or the Bcl-2 homologue Bak. J. Cell Biol., 136, 215-227.
26. Milligan, C.E., Prevette, D., Yaginuma, H., Homma, S., Cardwell, C., Fritz, L.C., Tomaselli, K.J., Oppenheim, R.W. and Schwartz, L.M. (1995) Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro. Neuron, 15, 385-393.
27. Muzio, M. et al. (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signaling complex. Cell, 85, 817-827.
28. Nagata, S. and Golstein, P. (1995) The Fas death factor. Science, 267, 1449-1456.
29. Nicholson, D.W. et al. (1995) Identification and inhibition of the ICE/ CED-3 protease necessary for mammalian apoptosis. Nature, 376, 37-43.
30. Norman, M.R. and Thompson, E.B. (1977) Characterization of a glucocorticoid-sensitive human lymphoid cell line. Cancer Res., 37, 3785-3791.
31. Peng, S.L., Robert, M.E., Hayday, A.C. and Craft, J. (1996) A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice. J. Exp. Med., 184, 1149-1154.
32. Pronk, G.J., Ramer, K., Amiri, P. and Williams, L.T. (1996) Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER. Science, 271, 808-810.
33. Ray, C.A., Black, R.A., Kronheim, S.R., Greenstreet, T.A., Sleath, P.R., Salvesen, G.S. and Pickup, D.J. (1992) Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme. Cell, 69, 597-604.
34. 2+-independent T cell-mediated cytotoxicity. J. Exp. Med., 177, 195-200.
35. Schlegel, J., Peters, I., Orrenius, S., Miller, D.K., Thornberry, N.A., Yamin, T.T. and Nicholson, D.W. (1996) CPP32/apopain is a key interleukin 1β converting enzyme-like protease involved in Fasmediated apoptosis. J. Biol. Chem., 271, 1841-1844.
36. Slee, E.A., Zhu, H., Chow, S.C., MacFarlane, M., Nicholson, D.W. and Cohen, G.M. (1996) Benzyloxycarbonyl-val-ala-asp (Ome) fluoromethylketone (ZVAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem. J., 315, 21-24.
37. Smith, C.A., Williams, G.T., Kingston, R., Jenkinson, E.J. and Owen, J.J.T. (1989) Antibodies to the CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature, 337, 181-184.
38. Tewari, M. and Dixit, V.M. (1995) Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Biol. Chem., 270, 3255-3260.
39. Thompson, C.B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science, 267, 1456-1462.
40. Trauth, B.C., Klas, C., Peters, A.M.J., Matzku, S., Moller, P., Falk, W., Debatin, K.M. and Krammer, P.H. (1989) Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science, 245, 301-305.
41. Truman, J.P., Choqueux, C., Tschopp, J., Vedrenne, J., Le Deist, F., Charron, D. and Mooney, N. (1997) HLA class II-mediated death is induced via Fas/Fas ligand interactions in human splenic B lymphocytes. Blood, 89, 1996-2007.
42. Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A. and Nagata, S. (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature, 356, 314-316.
43. White, K., Tahaoglu, E. and Steller, H. (1996) Cell killing by the Drosophila gene reaper. Science, 271, 805-807.
44. Whyte, M. (1996) ICE/CED-3 proteases in apoptosis. Trends Cell Biol., 6, 245-248.
45. Wyllie, A.H., Kerr, J.F.R and Currie, A.R. (1980) Cell death: the significance of apoptosis. Int. Rev. Cytol., 68, 251-306.
46. Xiang, J., Chao, D.T. and Korsmeyer, S.J. (1996) Bax-induced cell death may not require interleukin 1 β-converting enzyme-like proteases. Proc. Natl Acad. Sci USA, 93, 14559-14563.
47. Yonehara, S., Ishii, A. and Yonehara, M. (1989) A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med., 169, 1747-1756.
48. Yuan, J. (1995) Molecular control of life and death. Curr. Biol., 7, 211-214.
49. Yuan, J., Shaham, S., Ledoux, S., Ellis, H.M. and Horvitz, J.R. (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β converting enzyme. Cell, 75, 641-652.
50. Zhu, H., Fearnhead, H.O. and Cohen, G.M. (1995) An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells. FEBS Lett., 374, 303-308.