Evolution of Aldolase Antibodies in Vitro: Correlation of Catalytic Activity and Reaction-based Selection

Journal of Molecular Biology

Volumn 335, Issue 4, 2004, Pages 1007-1018

  Tanaka, Fujie ^a   Fuller, Roberta ^a   Shim, Hyunbo ^a   Lerner, Richard A ^a   Barbas III, Carlos F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Aldolase antibody; Catalytic antibody; Enamine; In vitro evolution; Phage display

Indexed keywords

ALDOLASE ANTIBODY; ALDOLASE ANTIBODY 33F12; ALDOLASE ANTIBODY 38C2; AMINO ACID DERIVATIVE; CATALYTIC ANTIBODY; ENAMINE; IMMUNOGLOBULIN F(AB) FRAGMENT; KETONE DERIVATIVE; LYSINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CATALYST; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; COVALENT BOND; ENZYME SPECIFICITY; GENE; HUMAN; IN VITRO STUDY; MOLECULAR EVOLUTION; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0345862284     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2003.11.014     Document Type: Article

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