Structural convergence in the active sites of a family of catalytic antibodies

Science

Volumn 275, Issue 5303, 1997, Pages 1140-1142

  Charbonnier, Jean Baptiste ^a,d   Golinelli Pimpaneau, Béatrice ^a   Gigant, Benoît ^a   Tawfik, Dan S ^b,e   Chap, Rachel ^b   Schindler, Daniel G ^b   Kim, Se Ho ^b   Green, Bernard S ^c   Eshhar, Zelig ^b   Knossow, Marcel ^a  

^a LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d DIF   (France)

^e MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC ANTIBODY; ESTERASE; HAPTEN; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME STABILITY; ENZYME STRUCTURE; HYBRIDOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIBODIES, CATALYTIC; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EVOLUTION, MOLECULAR; HAPTENS; HYDROGEN BONDING; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; PHOSPHONIC ACIDS; PROTEIN CONFORMATION; TYROSINE;

ANIMALIA;

EID: 15444355643     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.275.5303.1140     Document Type: Article

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29. We thank J. Janin and D. Thomas for reading of the manuscript and R. A. Lerner for stimulating discussions; M. Pique for enthusiastic help in making the figures; R. Fourme and J.-P. Benoit for assistance during the use of the LURE Synchrotron. Supported in part by D.G.A. grant 94/128 (M.K.).