Viral induction of a chronic asthma phenotype and genetic segregation from the acute response

Journal of Clinical Investigation

Volumn 110, Issue 2, 2002, Pages 165-175

  Walter, Michael J ^a   Morton, Jeffrey D ^a   Kajiwara, Naohiro ^a   Agapov, Eugene ^a   Holtzman, Michael J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1;

ANIMAL CELL; ARTICLE; ASTHMA; BRONCHIOLITIS; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; GENE SEGREGATION; GOBLET CELL; LOWER RESPIRATORY TRACT INFECTION; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROVOCATION TEST; RNA VIRUS INFECTION; VIRUS INDUCTION; WHEEZING;

EID: 0036070857     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0214345     Document Type: Article

References (76)

1. Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity
2. Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology
3. Nebulized IFN-gamma inhibits the development of secondary allergic responses in mice
4. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice
5. Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides
6. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
7. Association of asthma with serum IgE levels and skin-test reactivity to allergens
8. Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects
9. Allergy and allergic diseases
10. Contributing factors to the pathobiology. The genetics of asthma
11. Evidence of ongoing mast cell and eosinophil activation in symptomatic asthma airway
12. Immunohistochemical characterization of the cellular infiltration in asthmatic bronchi
13. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice
14. Eotaxins. Contributing to the diversity of eosinophil recruitment and activation
15. Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation
16. Allergen-specific Th1 cells Fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
17. Interleukin-13: Central mediator of allergic asthma
18. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma
19. Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins
20. IL-5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
21. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity
22. The one-two of T helper cells: Does interferon-gamma knock out the Th2 hypothesis for asthma?
23. Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland
24. Lessons from allergic rhinitis versus asthma pathogenesis and treatment
25. Sorting out the cytokines of asthma
26. Immunity, inflammation, and remodeling in the airway epithelial barrier: Epithelial-viral-allergic paradigm
27. Direct suppression of Stat1 function during adenoviral infection
28. Patterns for RANTES secretion and intercellular adhesion molecule-1 expression mediate transepithelial T cell traffic based on analyses in vitro and in vivo
29. Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization
30. Constitutive activation of an epithelial signal transducer and activator of transcription (Stat1) pathway in asthma
31. IL-12 p40 production by barrier epithelial cells during airway inflammation
32. Parainfluenza viruses
33. Respiratory syncytial virus infection: Immune response, immunopathogenesis, and treatment
34. Epidemiologic and clinical evidence of a respiratory syncytial virus-reactive airway disease link
35. Persistence of viruses
36. Selective differences in vascular endothelial- vs. airway epithelial-T cell adhesion mechanisms
37. A hierarchy for integrin expression and adhesiveness among T cell subsets that is linked to TCR gene usage and emphasizes V delta 1+ gamma delta T cell adherence and tissue retention
38. Human cytomegalovirus IE1 and IE2 proteins are mutagenic and mediate "hit and run" oncogenic transformation in cooperation with the adenovirus E1A proteins
39. "Hit and run" transformation by adenovirus oncogenes
40. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
41. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice
42. Novel isoforms of murine intercellular adhesion molecule-1 generated by alternative RNA splicing
43. A sensitive plaque assay for Sendai virus in an established line of monkey kidney cells
44. Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways
45. Measurement of airway responsiveness in allergic mice using barometric plethysmography
46. Characterization of a murine model of allergic pulmonary inflammation
47. Selective induction of intercellular adhesion molecule-1 by interferon-gamma in human airway epithelial cells
48. Eosmophil recruitment to the lung in a murine model of allergic inflammation
49. P-selectin/ICAM-1 double mutant mice: Acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli
50. Role of alveolar epithelial cell intercellular adhesion molecule-1 in host defense against Klebsiella pneumoniae
51. Delayed clearance of Sendai virus in mice lacking class I MHC-restricted CD8+ T cells
52. The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon
53. CD4+ T cell priming accelerates the clearance of Sendai virus in mice, but has a negative effect on CD8+ T cell memory
54. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
55. Importance of airway inflammation for hyperresponsiveness induced by ozone in dogs
56. Virus-induced airway hyperresponsiveness and asthma
57. Selective interaction of a subset of interferon-gamma response element binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells
58. Stat1 depends on transcriptional synergy with Sp1
59. Targeted inhibition of interferon-gamma-dependent ICAM-1 expression using dominant-negative Stat1
60. Induction, duration, and resolution of airway goblet cell hyperplasia in a murine model of atopic asthma: Effect of concurrent infection with respiratory syncytial virus and response to dexamethasone
61. Could asthma worsen by stimulating the T helper type 1 (Th1) response?
62. Effects of respiratory syncytial virus persistence on airway responsiveness and inflammation in guinea-pigs
63. Prevention of chronic postbronchiolitis airway sequelae with IFN-gamma treatment in rats
64. Persistent adenoviral infection and chronic airway obstruction in children
65. Asthma: An epidemic in the absence of infection
66. Reduced interferon-gamma production in infants with bronchiolitis and asthma
67. Fluticasone inhibits but does not reverse allergen-induced structural airway changes
68. Mice lacking the IFN-gamma receptor have an impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile
69. Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections
70. Protection from respiratory virus infections can be mediated by antigen-specific CD4+ T cells that persist in the lungs
71. Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia
72. Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophila during experimental murine respiratory syncytial virus infection
73. CD8 T cells are essential in the development of respiratory syncytial virus-induced lung eosinophilia and airway hyper-responsiveness
74. Glucocorticoids in T cell development and function
75. T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production
76. Trophic slime, allergic slime