Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?

Trends in Pharmacological Sciences

Volumn 24, Issue 3, 2003, Pages 103-106

  Reddy, Doodipala S ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; FLUOXETINE; NEUROSTEROID; TETRAHYDRODEOXYCORTICOSTERONE;

ALLOSTERISM; BRAIN FUNCTION; BRAIN LEVEL; DEPRESSION; DRUG EFFECT; EPILEPSY; GABAERGIC TRANSMISSION; HORMONE ACTION; HUMAN; INFANTILE SPASM; NERVE CELL EXCITABILITY; NONHUMAN; PATHOGENESIS; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; REVIEW; SEIZURE SUSCEPTIBILITY;

EID: 0037334387     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(03)00023-3     Document Type: Review

References (32)

1. 4-subunit suppression prevents withdrawal properties of an endogenous steroid. Nature. 392:1998;926-930.
2. Reddy D.S., et al. Neurosteroid withdrawal model of perimenstrual catamenial epilepsy. Epilepsia. 42:2001;328-336.
3. Concas A., et al. Role of brain allopregnanolone in the plasticity of γ-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery. Proc. Natl. Acad. Sci. U. S. A. 95:1998;13284-13289.
4. Herbison A.E. Physiological roles for the neurosteroid allopregnanolone in the modulation of brain function during pregnancy and parturition. Progr. Brain Res. 133:2001;39-47.
5. A receptor function and seizure susceptibility. J. Neurosci. 42:2002;3795-3805.
6. Aird R.B. The effect of desoxycorticosterone in epilepsy. J. Nerv. Ment. Dis. 99:1944;501-510.
7. Aird R.B., Gordan G.S. Anticonvulsive properties of desoxycorticosterone. J. Am. Med. Assoc. 145:1951;715-719.
8. Reddy D.S., et al. Seizure resistance of progesterone receptor knockout mice. FASEB J. 15:2001;A223-A223.
9. Crawley J.N., et al. Anxiolytic activity of an endogenous adrenal steroid. Brain Res. 398:1986;382-385.
10. Rupprecht R., et al. Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology. Brain Res. Rev. 37:2001;59-67.
11. A receptor complex: the pharmacological properties and therapeutic potential of epalons. Crit. Rev. Neurobiol. 9:1995;207-227.
12. A receptors by endogenous and synthetic neuroactive steroids. Brain Res. Rev. 37:2001;68-80.
13. Kokate T.G., et al. Anticonvulsant activity of neurosteroids: correlation with γ-aminobutyric acid-evoked chloride current potentiation. J. Pharmacol. Exp. Ther. 270:1994;1223-1229.
14. Strohle A., et al. Fluoxetine decreases concentrations of 3α, 5α-tetrahydrodeoxycorticosterone (THDOC) in major depression. J. Psychiatr. Res. 34:2000;183-186.
15. Purdy R.H., et al. Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in the rat brain. Proc. Natl. Acad. Sci. U. S. A. 88:1991;4553-4557.
16. Rogawski M.A., Reddy D.S. Neurosteroids and infantile spasms: the deoxycorticosterone hypothesis. Int. Rev. Neurobiol. 49:2002;199-219.
17. A receptor function after acute stress. Neuroendocrinology. 63:1996;166-172.
18. Barbaccia M.L., et al. Stress and neuroactive steroids. Int. Rev. Neurobiol. 46:2001;243-272.
19. Pericic D., et al. Anticonvulsive effect of swim stress in mice. Pharmacol. Biochem. Behav. 66:2000;879-886.
20. Morrow A.L., et al. The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brain Res. Rev. 37:2001;98-109.
21. Frucht M.M., et al. Distribution of seizure precipitants among epilepsy syndromes. Epilepsia. 41:2000;1534-1539.
22. A-antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder. Psychol. Med. 30:2000;1227-1231.
23. Strohle A., et al. Concentrations of 3α-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery. Biol. Psychiatry. 45:1999;274-277.
24. Romeo E., et al. Effects of antidepressant treatment on neuroactive steroids in major depression. Am. J. Psychiatry. 155:1998;910-913.
25. Uzunov V., et al. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc. Natl. Acad. Sci. U. S. A. 95:1998;3239-3244.
26. Dong E., et al. Brain 5α-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation. Proc. Natl. Acad. Sci. U. S. A. 98:2001;2849-2854.
27. A receptor function in rat brain. J. Neurochem. 75:2000;732-74028.
28. Serra M., et al. Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine. J. Psychopharmacol. 16:2002;133-138.
29. Reddy D.S., Kulkarni S.K. Development of neurosteroid-based novel psychotropic drugs. Progr. Med. Chem. 37:2000;135-175.
30. Mellon S.H., Griffin L.D. Neurosteroids: biochemistry and clinical significance. Trends Endocrinol. Metab. 13:2002;35-43.
31. Baulieu E.E. Steroid hormones in the brain: several mechanisms? Fuxe K., et al. Steroid Hormone Regulation of the Brain. 1981;3-14 Pergamon Press.
32. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 6:1992;2311-2322.