Requirements for Specific Binding of Low Affinity Inhibitor Fragments to the SH2 Domain of pp60Src Are Identical to Those for High Affinity Binding of Full Length Inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 24, 2003, Pages 5184-5195

  Lange, Gudrun ^b,c   Lesuisse, Dominique ^a   Deprez, Pierre ^a   Schoot, Bernard ^a   Loenze, Petra ^b   Bénard, Didier ^a   Marquette, Jean Pierre ^a   Broto, Pierre ^a   Sarubbi, Edoardo ^a   Mandine, Eliane ^a  

^a SANOFI   (France)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^c BAYER CROPSCIENCE AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE DERIVATIVE; AZEPINE DERIVATIVE; BISPHOSPHONIC ACID DERIVATIVE; CARBAMIC ACID DERIVATIVE; FLUOROPROPANEDIOIC ACID; PHOSPHOTYROSINE; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ARTICLE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; IC 50; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SRC HOMOLOGY DOMAINS;

EID: 0242439332     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020970s     Document Type: Article

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