Examination of novel non-phosphorus-containing phosphotyrosyl mimetics against protein-tyrosine phosphatase-1B and demonstration of differential affinities toward Grb2 SH2 domains

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 9, 2000, Pages 923-927

  Gao, Yang ^a   Wu, Li ^b   Luo, Juliet H ^c   Guo, Ribo ^c   Yang, Dajun ^c   Zhang, Zhong Yin ^b   Burke Jr , Terrence R ^a  

^a Laboratory of Medicinal Chemistry   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; TYROSINE DERIVATIVE;

ARTICLE; DRUG BINDING; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CATALYSIS; GRB2 ADAPTOR PROTEIN; HUMANS; MOLECULAR MIMICRY; PHOSPHOTYROSINE; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034193474     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00124-4     Document Type: Article

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