Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with in vivo antiresorptive activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 17, 2000, Pages 9373-9378

  Shakespeare, William ^a   Yang, Michael ^a   Bohacek, Regine ^a   Cerasoli, Franklin ^a   Stebbins, Karin ^a   Sundaramoorthi, Raji ^a   Azimioara, Mihai ^a   Vu, Chi ^a   Pradeepan, Selvi ^a   Metcalf III, Chester ^a   Haraldson, Chad ^a   Merry, Taylor ^a   Dalgarno, David ^a   Narula, Surinder ^a   Hatada, Marcos ^a   Lu, Xiaode ^a   Van Schravendijk, Marie Rose ^a   Adams, Susan ^a   Violette, Shelia ^a   Smith, Jeremy ^a   Guan, Wei ^a   Bartlett, Catherine ^a   Herson, Jay ^b   Iuliucci, John ^a   Weigele, Manfred ^a   Sawyer, Tomi ^a   more..

^a ARIAD PHARMACEUTICALS INC   (United States)

^b Applied Logic Associates Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AP 22408; AP 22409; AP 22650; PARATHYROID HORMONE[1-34]; PHOSPHOPEPTIDE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BONE DISEASE; CHEMICAL STRUCTURE; CONTROLLED STUDY; FEMALE; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; RABBIT; RAT; X RAY CRYSTALLOGRAPHY;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 12944281813     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.17.9373     Document Type: Article

References (33)

1. Levitzki, A. (1999) Pharmacol. Ther. 82, 231-239.
2. Tonks, N. K. (1996) Adv. Pharmacol. 36, 91-119.
3. Cohen, G. B., Ren, R. & Baltimore, D. (1995) Cell 80, 237-248.
4. Thomas, S. M. & Brugge, J. S. (1997) Annu. Rev. Cell Dev. Biol. 13, 513-609.
5. Fukui, Y. & Hanafusa, H. (1991) Mol. Cell. Biol. 11, 871-874.
6. Schaller, M. D., Hilderbrand, J. D., Shannon, J. D., Fox, J. W., Vines, R. R. & Parsons, J. T. (1994) Mol. Cell. Biol. 14, 1680-1688.
7. Taylor, S. J. & Shalloway, D. (1994) Nature (London) 368, 867-871.
8. Petch, L. A., Bockholt, S. M., Bouton, A., Parsons, J. T. & Burridge, K. (1995) J. Cell. Sci. 108, 1371-1379.
9. Soriano, P., Montgomery, C., Geske, R. & Bradley, A. (1991) Cell 64, 693-702.
10. Boyce, B. F., Yoneda, T., Lowe, C., Soriano, P. & Mundy, G. R. (1992) J. Clin. Invest. 90, 1622-1627.
11. Schwartzberg, P. L., Xing, L., Hoffmann, O., Lowell, C. A., Garrett, L., Boyce, B. F. & Varmus, H. E. (1997) Genes Dev. 11, 2835-2844.
12. Sawyer, T. K. (1998) Biopolymers 47, 243-261.
13. Lunney, E. A., Para, K. S., Rubin, J. R., Humblet, C., Fergus, J. H., Marks, J. S. & Sawyer, T. K. (1997) J. Am. Chem. Soc. 119, 12471-12476.
14. Lunney, E. A., Para, K. S., Plummer, M. S., Prasad, J. V. N. V., Saltiel, A. R., Sawyer, T. & Shahripour, A. (1997) PCT Intl. Patent W097/12903.
15. Botfield, M. C. & Green, J. (1995) Annu. Rep. Med. Chem. 30, 227-237.
16. Thurieau, C., Simonet, S., Paladino, J., Prost, J.-F., Verbeuren, T. & Fauchére, J.-L. (1994) J. Med. Chem. 37, 625-629.
17. Tong, L., Warren, T. C., King, J., Betageri, R., Rose, J. & Jakes, S. (1996) J. Mol. Biol. 256, 601-610.
18. McMartin, C. & Bohacek, R. S. (1997) J. Comput. Aided Mol. Design 11, 333-344.
19. ThistleSoft, Inc. (1996) FLO96 (ThistleSoft, Colebrook, CT).
20. Lynch, B. A., Loiacono, K. A., Tiong, C. L., Adams, S. E. & Macneil, I. A. (1997) Anal. Biochem. 247, 77-82.
21. Violette, S. M., Shakespeare, W. C., Bartlett, C., Guan, W., Smith, J. A., Rickles, R. J., Bohacek, R. S., Holt, D. A., Baron, R. & Sawyer, T. K. (2000) Chem. Biol. 7, 225-235.
22. Eck, M. J., Shoelson, S. E. & Harrison, S. C. (1993) Nature (London) 362, 87-91.
23. Waksman, G., Shoelson, S. E., Pant, N., Cowburn, D. & Kuriyan, J. (1993) Cell 72, 779-790.
24. Frost, H. M. & Lee, W. S. S. (1992) Bone Miner. 18, 227-236.
25. Green, J. R., Müller, K. & Jaeggi, K. A. (1994) J. Bone Miner. Res. 9, 745-751.
26. Schwartzberg, P. (1998) Oncogene 17, 1463-1468.
27. Klinghoffer, R. A., Sachsenmaier, C., Cooper, J. A. & Soriano, P. (1999) EMBO J. 18, 2459-2471.
28. Schlaepfer, D. D., Broome, M. A. & Hunter, T. (1997) Mol. Cell. Biol. 17, 1702-1713.
29. Superti-Furga, G. & Courtneidge, S. A. (1995) BioEssays 17, 321-330.
30. Waksman, G., Kominos, D., Robertson, S. C., Pant, N., Baltimore, D., Birge, R. B., Cowburn, D., Hanafusa, H., Mayer, B. J., Overduin, M., et al. (1992) Nature (London) 358, 646-653.
31. Shakespeare, W. C., Bohacek, R. S., Narula, S. S., Azimioara, M. D., Yuan, R. W., Dalgarno, D. C., Madden, L., Botfield, M. C. & Holt, D. A. (1999) Bioorg. Med. Chem. Lett. 9, 3109-3112.
32. Charifson, P. S., Shewchuk, L. M., Rocque, W., Hummel, C. W., Jordan, S. R., Mohr, C., Pacofsky, G. J., Peel, M. R., Rodriguez, M., Sternbach, D. D. & Counsler, T. G. (1997) Biochemistry 36, 6283-6293.
33. Alligood, K. J., Charifson, P. S., Crosby, R., Consler, T. G., Feldman, P. L., Gampe, R. T., Gilmer, T. M., Jordan, S. R., Milstead, M. W., Mohr, C., Peel, M. R., et al. (1998) Bioorg. Med. Chem. Lett. 7, 1189-1194.