Principles governing the binding of a class of non-peptidic inhibitors to the SH2 domain of src studied by X-ray analysis

Journal of Medicinal Chemistry

Volumn 45, Issue 14, 2002, Pages 2915-2922

  Lange, Gudrun ^a,b   Mandine, Eliane ^a   Lesuisse, Dominique ^a   Deprez, Pierre ^a   Schoot, Bernard ^a   Loenze, Petra ^a   Bénard, Didier ^a   Marquette, Jean Pierre ^a   Broto, Pierre ^a   Sarubbi, Edoardo ^a  

^a SANOFI   (France)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

ARTICLE; DRUG BINDING; DRUG PROTEIN BINDING; HYDROPHOBICITY; IC 50; PROTEIN DOMAIN; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY;

BIPHENYL COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037019282     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0110800     Document Type: Article

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