A novel phosphotyrosine mimetic 4′-carboxymethyloxy-3′-phosphonophenylalanine (Cpp): Exploitation in the design of nonpeptide inhibitors of pp60Src SH2 domain

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 17, 2001, Pages 2319-2323

  Kawahata, Noriyuki ^a   Yang, Michael G ^a   Luke, George P ^a   Shakespeare, William C ^a   Sundaramoorthi, Raji ^a   Wang, Yihan ^a   Johnson, Daniel ^a   Merry, Taylor ^a   Violette, Shelia ^a   Guan, Wei ^a   Bartlett, Catherine ^a   Smith, Jeremy ^a   Hatada, Marcos ^a   Lu, Xiaode ^a   Dalgarno, David C ^a   Eyermann, Charles J ^a   Bohacek, Regine S ^a   Sawyer, Tomi K ^a  

^a ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' CARBOXYMETHYLOXY 3' PHOSPHONOPHENYLALANINE; PHENYLALANINE DERIVATIVE; PHOSPHOTYROSINE; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MUTANT; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAMIDES; BINDING SITES; BONE RESORPTION; CRYSTALLOGRAPHY, X-RAY; DENTIN; DRUG DESIGN; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR MIMICRY; MUTATION; OSTEOCLASTS; PHOSPHONIC ACIDS; PHOSPHOTYROSINE; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RABBITS; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17944368273     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00446-2     Document Type: Article

References (25)