Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): Identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state

Journal of Biological Chemistry

Volumn 278, Issue 46, 2003, Pages 46052-46063

  Zhang, Da Wei ^a   Gu, Hong Mei ^b   Situ, Donna ^a,b   Haimeur, Anass ^a   Cole, Susan P C ^a,b   Deeley, Roger G ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL MEMBRANES; CHEMOTHERAPY; MUTAGENESIS; PROTEINS;

MULTIDRUG RESISTANCE PROTEINS; MUTATIONS;

BIOCHEMISTRY;

ABC TRANSPORTER; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID DERIVATIVE; ANTHRACYCLINE ANTIBIOTIC AGENT; ASPARAGINE; ASPARTIC ACID; DOXORUBICIN; ESTRADIOL 17 GLUCURONIDE; ETOPOSIDE; GLUTAMIC ACID; LEUKOTRIENE C4; LYSINE; MULTIDRUG RESISTANCE PROTEIN 1; NUCLEOTIDE; SERINE; VINCRISTINE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOPLASM; ENZYME SPECIFICITY; GENE MUTATION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF;

PROKARYOTA;

EID: 0242412511     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308403200     Document Type: Article

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